DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and CG14891

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_650560.1	Gene:	CG14891 / 42013	FlyBaseID:	FBgn0038445	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	115/546 - (21%)
Similarity:	186/546 - (34%)	Gaps:	167/546 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 NYYTEIDAIMLCGRTVTKTQNLLAKQQITQHSRTLVSPPPDAIGSTSGDGSGGSISHKLRTLKFQ 287
            |:|.|        |.|..|::....:|:|                         ||...|.||:|
  Fly    10 NFYIE--------RGVAYTEDREVVRQLT-------------------------ISGSRRFLKYQ 41

  Fly   288 ----------------PNCGEDGATKLHEFINNDLSQFLADNCVDGEAAAPQ------------- 323
                            ......|:...:|..:...:.:...:.:||.....|
  Fly    42 LLKYFSIFGKVEKLHWKKKKRSGSVLFYEATHAAKALYCTKHTIDGHDLYLQASTSWHPTPVEES 106

  Fly   324 --ICLTDLPF--EILLRILSYLDLKSLFRVGHVSRTF---YDISRHPLLYAEISLKPYWDVASSE 381
              :...|||.  :|..::|.||.|............|   |::..|.:.:          |.:.:
  Fly   107 GTLSAYDLPITDDIWWKVLDYLSLNERLNFAASCERFQAIYELDSHRINH----------VLNMK 161

  Fly   382 LLCTLARRATMLRKLDL-----SWCGGFGNVSP-----TEFKKFLTQRGDNLTHLRLNSCKFLNA 436
            .:|||..|  ::::|.|     ..|...|.:.|     |||.:.|.....|||.|..    |..:
  Fly   162 DVCTLTHR--VIKRLMLLSGKHIHCVTGGPLHPNWPYLTEFVQLLGVSCPNLTELSF----FKIS 220

  Fly   437 SCIENVGIVCD------NLIELSLRNCATEPPLLNFSCLANLKNLERLDLFQTY----------- 484
            ..:.::..:.|      |:..:|||.|..:.  .:..||..|..|:.||:.:.:
  Fly   221 VSLAHMTHLFDGANGLINITNISLRRCNLKD--AHIYCLQMLSKLKSLDIRENFSIKGDSLKSLP 283

  Fly   485 FETELL------------LSMLEGNRKLKHLNLAFCG--VSVNMDN-VAAHLATYNTQLISLDLW 534
            ...|:|            |..|..   |.||....|.  |....|| :...||.|...|..|:|
  Fly   284 ISLEILNVSGCVDLSPKCLIQLAA---LSHLRELRCPGIVKFAKDNELYGRLAHYCPMLEVLEL- 344

  Fly   535 KAHFLSSRGLQSLARLHQL-----EELDL------------GWCMREASLGDGL---------FQ 573
             ..|::...|..|:|||.|     .:||.            .:.:|...:.|..         ..
  Fly   345 -TDFMNVIQLGGLSRLHTLVIHSSAQLDYHVNNVLLTSIAESYSLRHLEILDSFGPMSDTSFDLS 408

  Fly   574 LLSNCPKLKKLFLSAVRGTTERDLMHIAALGK--NLEQLDLMGILNITHERVYDILVNCPKLQLL 636
            :.|...:|:.|.|.....||    :|:..|.|  .||.|||.|..|:::|.|..:..:...|:.|
  Fly   409 IFSQLKELRTLILHNQNFTT----LHLMGLQKLSTLEFLDLSGSPNLSNEVVAKLTKSLSGLRRL 469

  Fly   637 DLSFCDNIMDRDFDLLAEWSRQFKVD 662
            .:.||. ::.|....:.|.:.:.:||
  Fly   470 KVDFCP-LITRQLTKILEGNPKLQVD 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	11/50 (22%)
		leucine-rich repeat	393..422	CDD:275381	9/38 (24%)
		leucine-rich repeat	423..442	CDD:275381	4/18 (22%)
		LRR_RI	437..>641	CDD:238064	60/263 (23%)
		leucine-rich repeat	449..474	CDD:275381	7/24 (29%)
		leucine-rich repeat	475..499	CDD:275381	7/46 (15%)
		leucine-rich repeat	500..527	CDD:275381	10/29 (34%)
		leucine-rich repeat	528..552	CDD:275381	8/23 (35%)
		AMN1	552..>660	CDD:187754	29/135 (21%)
		leucine-rich repeat	553..580	CDD:275381	6/52 (12%)
		leucine-rich repeat	581..606	CDD:275381	8/26 (31%)
		leucine-rich repeat	607..632	CDD:275381	9/24 (38%)
		leucine-rich repeat	633..652	CDD:275381	5/18 (28%)
CG14891	NP_650560.1	RRM_6	25..91	CDD:290958	12/90 (13%)
		AMN1	<199..352	CDD:187754	38/163 (23%)
		leucine-rich repeat	211..237	CDD:275381	5/29 (17%)
		leucine-rich repeat	239..262	CDD:275381	7/24 (29%)
		leucine-rich repeat	263..285	CDD:275381	3/21 (14%)
		leucine-rich repeat	286..338	CDD:275381	14/54 (26%)
		leucine-rich repeat	339..387	CDD:275381	12/49 (24%)
		leucine-rich repeat	388..415	CDD:275381	3/26 (12%)
		leucine-rich repeat	416..439	CDD:275381	8/26 (31%)
		leucine-rich repeat	440..465	CDD:275381	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458001
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830