DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fbxl4 and CG12402

DIOPT Version :9

Sequence 1:NP_572951.1 Gene:Fbxl4 / 32378 FlyBaseID:FBgn0030555 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_001303481.1 Gene:CG12402 / 41714 FlyBaseID:FBgn0038202 Length:671 Species:Drosophila melanogaster


Alignment Length:530 Identity:120/530 - (22%)
Similarity:186/530 - (35%) Gaps:188/530 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 LDSRRFAPSLKKTTMLTKTLRIDFNH------------SRLNYY----TEIDAI------MLCGR 236
            ||.:  .|:||..|:.| |:.:|..|            |.|..:    ..:||:      :...|
  Fly   182 LDGK--LPNLKVLTIAT-TMSMDDQHLAAMDDLDMKQFSHLVGFECDGVSLDAVLKMRMLLQLRR 243

  Fly   237 TVTKTQ-----------NLLAKQQITQ-HSRTLV--------SPPPDAIGSTSGDGSGGSISHKL 281
            |..|.|           |..|...:.| |:.|||        ||..|    |..........|.|
  Fly   244 TENKVQLRHLQFEFRRNNENALLDVLQDHAETLVCVNLFFSCSPGID----TREWCRAFENMHNL 304

  Fly   282 RTLKFQPNCGEDGATKLHEFINNDLSQFLADNCVDGEAAAPQICLTDLPFEILLRILSYLDLKSL 346
            ||||...||                      :.|..||.     |..:|....:|.|....:.||
  Fly   305 RTLKLSGNC----------------------HLVLLEAV-----LRAVPESAPIRQLDLTGMLSL 342

  Fly   347 FRVGHVSRTFYDISRHPLLYAEISLKPYWDVASSELLCTLARR-ATMLRKLDLSWCGGFGNVSPT 410
                                            ::|||..:|.: .:.|:.|||.:|         
  Fly   343 --------------------------------TNELLLYVAGKWQSTLKVLDLMFC--------- 366

  Fly   411 EFKKFLTQRGDNLTHLRLNSCKFLNASCIENVGIVCDNLIELSLRNC--ATEPPLL-------NF 466
                  .|               |||:||:.:..:...|..|::..|  .|...||       |:
  Fly   367 ------VQ---------------LNANCIDALRQLSGRLEALTMAYCRELTGTGLLQGLAGDINY 410

  Fly   467 SCLANLKNLERLDLFQTYF-ETELLLSMLEGNRKLKHLNLAFCGVSVNMDNVAAHLATYNTQLIS 530
            |       |:.|.|.:|.| :...:..:||....|:.|:|..|..:|. |...|.:..|.|:|.:
  Fly   411 S-------LQELHLEETIFLDESSMCQLLERLPNLRRLSLDNCRQAVT-DRTMATICQYQTRLRN 467

  Fly   531 LDLWKAHFLSSRGLQS-------LARLHQLEELDLGWC----------------MREASLG---- 568
            |::.....::.:||..       ::||..|:||:|..|                :|..|||    
  Fly   468 LNIEYCMKITDQGLMGYGDTPYPISRLRGLKELNLRGCRNVTDSSLMVGLKLPELRALSLGYCNR 532

  Fly   569 ---DGLFQLLSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGILNITHERVYDILVNC 630
               :|...|..|||.|:.|.:|:.....:..:::|.:..|.|..|:|.....:|.:.::.||.:.
  Fly   533 LTSEGFEALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKRLRVLNLSNCTKLTLQSIHHILAHG 597

  Fly   631 PKL-QLLDLS 639
            ..| ||:..|
  Fly   598 HNLVQLIACS 607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fbxl4NP_572951.1 F-box-like 326..372 CDD:289689 6/45 (13%)
leucine-rich repeat 393..422 CDD:275381 6/28 (21%)
leucine-rich repeat 423..442 CDD:275381 5/18 (28%)
LRR_RI 437..>641 CDD:238064 61/244 (25%)
leucine-rich repeat 449..474 CDD:275381 8/33 (24%)
leucine-rich repeat 475..499 CDD:275381 7/24 (29%)
leucine-rich repeat 500..527 CDD:275381 8/26 (31%)
leucine-rich repeat 528..552 CDD:275381 6/30 (20%)
AMN1 552..>660 CDD:187754 29/112 (26%)
leucine-rich repeat 553..580 CDD:275381 13/49 (27%)
leucine-rich repeat 581..606 CDD:275381 4/24 (17%)
leucine-rich repeat 607..632 CDD:275381 6/24 (25%)
leucine-rich repeat 633..652 CDD:275381 4/8 (50%)
CG12402NP_001303481.1 F-box 75..117 CDD:279040
leucine-rich repeat 281..303 CDD:275381 4/25 (16%)
LRR_RI <297..482 CDD:238064 59/281 (21%)
leucine-rich repeat 304..330 CDD:275381 12/52 (23%)
leucine-rich repeat 331..357 CDD:275381 8/57 (14%)
leucine-rich repeat 358..379 CDD:275381 11/50 (22%)
leucine-rich repeat 384..409 CDD:275381 6/24 (25%)
leucine-rich repeat 412..437 CDD:275381 7/24 (29%)
AMN1 430..595 CDD:187754 41/165 (25%)
leucine-rich repeat 438..464 CDD:275381 8/26 (31%)
leucine-rich repeat 465..496 CDD:275381 6/30 (20%)
leucine-rich repeat 497..521 CDD:275381 5/23 (22%)
leucine-rich repeat 522..547 CDD:275381 8/24 (33%)
leucine-rich repeat 548..573 CDD:275381 4/24 (17%)
leucine-rich repeat 574..599 CDD:275381 6/24 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45456936
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.740

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