DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and Ppa

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	118/561 - (21%)
Similarity:	197/561 - (35%)	Gaps:	159/561 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 MLTKTLRIDFNHSRLNYYTEIDAIMLCGRTVTKTQNLLAKQQITQHSRTLVSPPPDAIGSTSGDG 272
            |.|.|..:.|:|..:.....:::  .||.:               .|....:....|||   |.|
  Fly     1 MATNTELLPFHHQTIAVLNNLNS--HCGGS---------------GSNGAATSGGAAIG---GAG 45

  Fly   273 SGGSISHKLRTLKFQ---PNCGEDGATKLHEFI-------------NNDLS--------QFLADN 313
            :||:.|..:..|..|   |.....|||..|..:             ::.|.        |..|..
  Fly    46 AGGAPSWAMDELYQQTELPGLTRTGATTTHHHLLRFTPYALHHRPPHHQLQTLPPALYLQHAAAA 110

  Fly   314 CVDGEAAA-----------------------PQI---CLTDLPFEILLRILSYLDLKSLFRVGHV 352
            .....|||                       |.:   .:::|..|:|.:|..:|.::.|.|...|
  Fly   111 AAAAAAAAAHAQHHHHHHHHLPHRPASPESPPPVEGTHISNLFPELLEQIFEHLPVRDLGRAAQV 175

  Fly   353 SRTFYDISRHPLLYAEISLKPYWDVASSELLCTLARR--------------------ATMLRKLD 397
            ...:.|.:....::..:..|.:...:|..|...|.:|                    ...|..|:
  Fly   176 CTAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGIKKVQILSLRRSLKDLVLGVPALTSLN 240

  Fly   398 LSWCGGFGNVSPTEFKKFLTQRGDNLTHLRLNSCKFLNASCIENVGIVCDNLIELSLRNCATEPP 462
            ||.|   .||:........:....||..|.|:.||.:..:.:..:.....||..|.|..|..
  Fly   241 LSGC---FNVADMNLGHAFSVDLPNLKTLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCN--- 299

  Fly   463 LLNFSCLA---NLKNLERLDLFQTYFETELLLSML--------EGNRKLKHLNLAFCGVSVNMDN 516
            :.|...|.   .||.|:.|:|...:..::..:..|        |||.:|::|.|..|  ....|.
  Fly   300 ITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIGHLAGFSRETAEGNLQLEYLGLQDC--QRLSDE 362

  Fly   517 VAAHLATYNTQLISLDLWKAHFLSSRGLQSLARLHQLEELDLGWCMREASLG------------- 568
            ...|:|...|.|.|::|.....::..||:.|||:.:||:|:|..|...:.:|
  Fly   363 ALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARMPKLEQLNLRSCDNISDIGMAYLTEGGSGINS 427

  Fly   569 ------------------DGLFQL----LSNCP--------------KLKKLFLSAVRGTTERDL 597
                              .||::|    |:.|.              :|:.|.:......|::.|
  Fly   428 LDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQITDHGMLKIAKALHELENLNIGQCSRITDKGL 492

  Fly   598 MHIAALGKNLEQLDLMGILNITHERVYDILVNCPKLQLLDL 638
            ..:|....||:.:||.|...::.:.: ||::..||||.|:|
  Fly   493 QTLAEDLTNLKTIDLYGCTQLSSKGI-DIIMKLPKLQKLNL 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	9/45 (20%)
		leucine-rich repeat	393..422	CDD:275381	7/28 (25%)
		leucine-rich repeat	423..442	CDD:275381	5/18 (28%)
		LRR_RI	437..>641	CDD:238064	61/262 (23%)
		leucine-rich repeat	449..474	CDD:275381	7/27 (26%)
		leucine-rich repeat	475..499	CDD:275381	7/31 (23%)
		leucine-rich repeat	500..527	CDD:275381	7/26 (27%)
		leucine-rich repeat	528..552	CDD:275381	8/23 (35%)
		AMN1	552..>660	CDD:187754	29/136 (21%)
		leucine-rich repeat	553..580	CDD:275381	11/75 (15%)
		leucine-rich repeat	581..606	CDD:275381	5/24 (21%)
		leucine-rich repeat	607..632	CDD:275381	6/24 (25%)
		leucine-rich repeat	633..652	CDD:275381	4/6 (67%)
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	9/40 (23%)
		AMN1	<226..>334	CDD:187754	25/113 (22%)
		leucine-rich repeat	236..256	CDD:275381	7/22 (32%)
		leucine-rich repeat	263..288	CDD:275381	5/24 (21%)
		leucine-rich repeat	289..314	CDD:275381	7/27 (26%)
		leucine-rich repeat	315..347	CDD:275381	7/31 (23%)
		AMN1	347..524	CDD:187754	39/179 (22%)
		leucine-rich repeat	348..373	CDD:275381	7/26 (27%)
		leucine-rich repeat	374..398	CDD:275381	8/23 (35%)
		leucine-rich repeat	399..424	CDD:275381	6/24 (25%)
		leucine-rich repeat	425..450	CDD:275381	2/24 (8%)
		leucine-rich repeat	451..475	CDD:275381	3/23 (13%)
		leucine-rich repeat	476..501	CDD:275381	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457941
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740