DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl4 and Fbxl13

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_011248071.1	Gene:	Fbxl13 / 320118	MGIID:	2443416	Length:	889	Species:	Mus musculus

Alignment Length:	666	Identity:	119/666 - (17%)
Similarity:	226/666 - (33%)	Gaps:	258/666 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 MRTYGDWWQRA--PSATR-EIQPQNLPKLETHD------YVVVYFEEFVVPTEVAIFETFNPGAV 165
            ::|:...|::.  |.|.: ||..:.:.|...||      |:                  ||
Mouse   108 VKTHFSGWKKVAIPRANQEEIMAEKMDKAIAHDNFRCQKYI------------------FN---- 150

  Fly   166 VRIWAYGLTKNWTCLWEATESDLSRPPPLDSRRFAPSLKKTTMLTKTLRIDFNHSRLNYYTEIDA 230
             |.:||.:                             :.:..::|..||:     |..:|.:...
Mouse   151 -RWFAYTV-----------------------------MSRERLITTLLRL-----RHLFYMQRQR 180

  Fly   231 IMLC-------GRTVTKTQNLLAKQQITQHSRTLVSPPPDAIGSTSGDGSGGSISHKLRTLKFQP 288
            |:|.       .::.|:..:|::|.::                             :|:..||
Mouse   181 IILAKWKERARHKSKTREDDLISKHEL-----------------------------QLKKWKF-- 214

  Fly   289 NCGEDGATKLHEFINNDLSQFLADNCVDGEAAAPQICLTDLPFEILLRILSYLDLKSLFRVGHVS 353
                    ||.:.|:  |...|:|..|:....|..|.:  ||.:.:|:|..||..|.:.....|:
Mouse   215 --------KLGKPIS--LEGSLSDIAVENRRIAFDISV--LPEQAILQIFLYLTFKDMMACSRVN 267

  Fly   354 RTFYDISRHPLLYAEISLKPYWDVASSELLCTLARRATMLRKLDLSWCGGFGNVSPTEFK-KFL- 416
            |::..:.:...|:..|......::|...::.||.:....:.:|:...|         :|: |.|
Mouse   268 RSWMAMIQRGSLWNSIDFSTVKNIADKCVVTTLQKWRLNVLRLNFRGC---------DFRTKTLK 323

  Fly   417 -TQRGDNLTHLRLNSCKFLNASCIENVGIVCDNLIELSLRNCATEPPLLNFSCLANLKNLERLDL 480
             .....||..|.::.|:......:.::...|..::.|:|.|          :.:.|    ..:.|
Mouse   324 AVSHCKNLQELNVSDCQSFTDESMRHISEGCPGVLYLNLSN----------TTITN----RTMRL 374

  Fly   481 FQTYFETELLLSMLEGNRKLKHLNLAFC------GVS-VNMDNVAAHLATYNTQLISLDLWKAHF 538
            ...||            ..|::|:||:|      |:. :|:.| ..|      :||.|||.....
Mouse   375 LPRYF------------HNLQNLSLAYCRKFTDKGLQYLNLGN-GCH------KLIYLDLSGCTQ 420

  Fly   539 LSSRGLQSLA---------RLHQLEELD-------LGWCMREAS--------LGDGLFQLLSNC- 578
            :|.:|.:::|         .::.:..|.       :..|.|.:|        :.|..|:.||:|
Mouse   421 ISVQGFRNIASSCTGIVHLTINDMPTLTDNCVKVLVEKCPRISSVVLIGSPHISDSAFKALSSCD 485

  Fly   579 ------------------------PKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGILNIT 619
                                    |.:..:::...:|.|:..|       |:|..|..:.:||:|
Mouse   486 LKKIRFEGNKRISDACFKSIDRNYPGINHIYMVDCKGLTDSSL-------KSLSLLKQLTVLNLT 543

  Fly   620 H-ERVYDI------------------LVN---------------CPKLQLLDLSFCDNIMDRDFD 650
            : .|:.||                  |.|               ||.|..|:|..|:::.|...:
Mouse   544 NCIRIGDIGLKHFFDGPASIRLRELNLTNCSLLGDSSVIRLSERCPNLHYLNLRNCEHLTDLAIE 608

  Fly   651 LLAEWSRQFKVDIKSS 666
            .:|.......||:..:
Mouse   609 YIASMLSLISVDLSGT 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	11/45 (24%)
		leucine-rich repeat	393..422	CDD:275381	5/31 (16%)
		leucine-rich repeat	423..442	CDD:275381	3/18 (17%)
		LRR_RI	437..>641	CDD:238064	54/293 (18%)
		leucine-rich repeat	449..474	CDD:275381	4/24 (17%)
		leucine-rich repeat	475..499	CDD:275381	3/23 (13%)
		leucine-rich repeat	500..527	CDD:275381	9/33 (27%)
		leucine-rich repeat	528..552	CDD:275381	8/32 (25%)
		AMN1	552..>660	CDD:187754	32/181 (18%)
		leucine-rich repeat	553..580	CDD:275381	9/66 (14%)
		leucine-rich repeat	581..606	CDD:275381	3/24 (13%)
		leucine-rich repeat	607..632	CDD:275381	11/58 (19%)
		leucine-rich repeat	633..652	CDD:275381	5/18 (28%)
Fbxl13	XP_011248071.1	F-box-like	240..284	CDD:372399	11/45 (24%)
		leucine-rich repeat	255..268	CDD:275381	3/12 (25%)
		leucine-rich repeat	280..306	CDD:275381	4/25 (16%)
		AMN1	306..475	CDD:187754	38/210 (18%)
		leucine-rich repeat	307..330	CDD:275381	5/31 (16%)
		leucine-rich repeat	331..356	CDD:275381	4/24 (17%)
		leucine-rich repeat	357..381	CDD:275381	7/49 (14%)
		leucine-rich repeat	382..409	CDD:275381	9/33 (27%)
		leucine-rich repeat	410..435	CDD:275381	8/24 (33%)
		leucine-rich repeat	436..461	CDD:275381	2/24 (8%)
		leucine-rich repeat	462..484	CDD:275381	5/21 (24%)
		AMN1	473..605	CDD:187754	26/138 (19%)
		leucine-rich repeat	486..511	CDD:275381	0/24 (0%)
		leucine-rich repeat	512..536	CDD:275381	6/30 (20%)
		leucine-rich repeat	537..564	CDD:275381	6/26 (23%)
		leucine-rich repeat	565..590	CDD:275381	3/24 (13%)
		leucine-rich repeat	591..610	CDD:275381	5/18 (28%)
		leucine-rich repeat	617..645	CDD:275381	2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810