DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and Fbxl17

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_038939705.1	Gene:	Fbxl17 / 316663	RGDID:	1309773	Length:	739	Species:	Rattus norvegicus

Alignment Length:	450	Identity:	87/450 - (19%)
Similarity:	154/450 - (34%)	Gaps:	156/450 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 PPPD-------------AIGSTSGDG--SGGSISHKLRTLKFQPNCGEDGATKLHEFINNDLSQF 309
            |||.             .|.:.:||.  :||:.....:.   ||..|:           :|..:.
  Rat   248 PPPPLCPAPASPASECAPIEAAAGDAVRAGGTAPSSAQQ---QPESGD-----------SDCQEP 298

  Fly   310 LADNCVDGEAAAPQI-CLTDLPFEILLRILSYLDLKSLFRVGHVSRTFYDISRHPLLYAEISLKP 373
            ..:.|.......|:| .:..||..|||:|.|.|.|.                 ...|.|.:..|
  Rat   299 PENPCDCHREPPPEIPDINQLPPSILLKIFSNLSLD-----------------ERCLSASLVCK- 345

  Fly   374 YWDVASSELLCTLARRATMLRKLDLSWCGGFGNVSPT-EFKKFLTQRGDNLTHLRLNSCKFLNAS 437
            ||.        .|.......::||||     .....| |..:.:..|..|:..:.::.|:.::.|
  Rat   346 YWR--------DLCLDFQFWKQLDLS-----SRQQVTDELLEKIASRSQNIVEINISDCRSMSDS 397

  Fly   438 CIENVGIVCDNLIELSLRNCATEPPLLNFSCLANLKNLERLDLFQTYFETELLLSMLEGNRKLKH 502
            .:..:...|..|:..:...|               |.|.         :|.::.
  Rat   398 GVCVLAFKCPGLLRYTAYRC---------------KQLS---------DTSIIA----------- 427

  Fly   503 LNLAFCGVSVNMDNVAAHLATYNTQLISLDLWKAHF-----LSSRGLQSL-ARLHQLEELDLGWC 561
                          ||:|...         |.|.|.     |:..||:.| ::..:|:::..|.|
  Rat   428 --------------VASHCPL---------LQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQC 469

  Fly   562 MREASLGDGLFQLLSNCPKLKKLFLSAVRGTTER----------DLMHIAALG------------ 604
            .:.:.  :|:..:..:|.||:::::...:..|::          ||..:..:|
  Rat   470 YKISD--EGMVVIAKSCLKLQRIYMQENKLVTDQSVKAFAEHCPDLQCVGFMGCSVTSKGVIHLT 532

  Fly   605 --KNLEQLDLMGILNITHERVYDILVNCPKLQLLDLSFCDN--IMDRDFDLLAEWSRQFK 660
              :||..|||..|..:.:|.|.:|:..|..|..|:|  |.|  |.||..:::|:..:..|
  Rat   533 KLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNL--CLNWIINDRCVEVIAKEGQSLK 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	11/45 (24%)
		leucine-rich repeat	393..422	CDD:275381	7/29 (24%)
		leucine-rich repeat	423..442	CDD:275381	2/18 (11%)
		LRR_RI	437..>641	CDD:238064	41/233 (18%)
		leucine-rich repeat	449..474	CDD:275381	2/24 (8%)
		leucine-rich repeat	475..499	CDD:275381	2/23 (9%)
		leucine-rich repeat	500..527	CDD:275381	3/26 (12%)
		leucine-rich repeat	528..552	CDD:275381	7/29 (24%)
		AMN1	552..>660	CDD:187754	30/133 (23%)
		leucine-rich repeat	553..580	CDD:275381	5/26 (19%)
		leucine-rich repeat	581..606	CDD:275381	5/48 (10%)
		leucine-rich repeat	607..632	CDD:275381	9/24 (38%)
		leucine-rich repeat	633..652	CDD:275381	8/20 (40%)
Fbxl17	XP_038939705.1	F-box-like	316..361	CDD:403981	15/70 (21%)
		leucine-rich repeat	357..382	CDD:275381	7/29 (24%)
		leucine-rich repeat	383..408	CDD:275381	3/24 (13%)
		AMN1	406..568	CDD:187754	39/221 (18%)
		leucine-rich repeat	409..434	CDD:275381	8/73 (11%)
		leucine-rich repeat	435..460	CDD:275381	7/24 (29%)
		leucine-rich repeat	461..486	CDD:275381	5/26 (19%)
		leucine-rich repeat	487..512	CDD:275381	2/24 (8%)
		leucine-rich repeat	513..536	CDD:275381	2/22 (9%)
		leucine-rich repeat	537..562	CDD:275381	9/24 (38%)
		leucine-rich repeat	563..588	CDD:275381	9/26 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810