DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fbxl4 and Fbxl15

DIOPT Version :9

Sequence 1:NP_572951.1 Gene:Fbxl4 / 32378 FlyBaseID:FBgn0030555 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_001101073.1 Gene:Fbxl15 / 309453 RGDID:1306444 Length:300 Species:Rattus norvegicus


Alignment Length:374 Identity:86/374 - (22%)
Similarity:126/374 - (33%) Gaps:137/374 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   317 GEAAAPQICLTDLPFE--ILLRILSYLDLKSLFRVGHVSRTFYDISRHPLLYAEISLKPYWDVAS 379
            ||.....:.|.|||:|  :|..:|:::.|:.|.|:..|||.|         .|.:.|.       
  Rat    10 GEQEPGAVRLLDLPWEDVLLPHVLNWVPLRQLLRLQRVSRAF---------RALVQLH------- 58

  Fly   380 SELLCTLARRATMLRKLDLSWCGGFGNVSPTEFKKFLTQRGDNLTHLRLNSCKFLNASCIENVGI 444
                  |||    ||:.|   ....|...|......|.:..:.|..|.|..|         :..:
  Rat    59 ------LAR----LRRFD---AAQVGPQIPRAALVRLLRDAEGLQELALAPC---------HEWL 101

  Fly   445 VCDNLIELSLRNCATEPPLLNFSCLANLKNLERLDLFQTYFETELLLSMLEGNRKLKHLNLAFCG 509
            :.::|:.:..||     |.|....||....|.|          ..|.::.||..:|:.::||.|.
  Rat   102 LDEDLVPVLARN-----PQLRSVALAGCGQLSR----------RALGALAEGCPRLQRISLAHCD 151

  Fly   510 VSVNMDNVAAHLATYNTQLISLDLWKAHFLSSRGLQSLARLHQLEELDLGWCMR----------- 563
                                    | ...|:.|||..  |...||||||..|.:           
  Rat   152 ------------------------W-VDGLALRGLAD--RCPALEELDLTACRQLKDEAIVYLAQ 189

  Fly   564 -------------EASLGDGLFQ-LLSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMG 614
                         .|::||...| |..|||:                          ||.|||.|
  Rat   190 RRGAGLRSLSLAVNANVGDTAVQELARNCPQ--------------------------LEHLDLTG 228

  Fly   615 ILNITHERVYDILVNCPKLQLLDLSFCDNIMDRDFDLLAEWSRQFKVDI 663
            .|.:..:.|..:...||.|:.|.:..|.::.:.....|    |:..|||
  Rat   229 CLRVGSDGVRTLAEYCPALRSLRVRHCHHVAEPSLSRL----RKRGVDI 273

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fbxl4NP_572951.1 F-box-like 326..372 CDD:289689 15/47 (32%)
leucine-rich repeat 393..422 CDD:275381 6/28 (21%)
leucine-rich repeat 423..442 CDD:275381 4/18 (22%)
LRR_RI 437..>641 CDD:238064 49/228 (21%)
leucine-rich repeat 449..474 CDD:275381 7/24 (29%)
leucine-rich repeat 475..499 CDD:275381 5/23 (22%)
leucine-rich repeat 500..527 CDD:275381 4/26 (15%)
leucine-rich repeat 528..552 CDD:275381 6/23 (26%)
AMN1 552..>660 CDD:187754 30/132 (23%)
leucine-rich repeat 553..580 CDD:275381 14/51 (27%)
leucine-rich repeat 581..606 CDD:275381 0/24 (0%)
leucine-rich repeat 607..632 CDD:275381 9/24 (38%)
leucine-rich repeat 633..652 CDD:275381 3/18 (17%)
Fbxl15NP_001101073.1 F-box 18..55 CDD:395521 15/45 (33%)
leucine-rich repeat 62..88 CDD:275381 6/28 (21%)
leucine-rich repeat 89..115 CDD:275381 7/39 (18%)
Interaction with SMURF1. /evidence=ECO:0000250 113..269 50/227 (22%)
leucine-rich repeat 116..141 CDD:275381 8/34 (24%)
AMN1 <139..>268 CDD:187754 39/185 (21%)
leucine-rich repeat 142..167 CDD:275381 10/51 (20%)
leucine-rich repeat 168..194 CDD:275381 7/25 (28%)
leucine-rich repeat 195..220 CDD:275381 7/24 (29%)
leucine-rich repeat 221..245 CDD:275381 8/23 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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