DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and Fbxl12

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001273458.1	Gene:	Fbxl12 / 30843	MGIID:	1354738	Length:	349	Species:	Mus musculus

Alignment Length:	277	Identity:	63/277 - (22%)
Similarity:	104/277 - (37%)	Gaps:	70/277 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   379 SSELLCTLARRATMLRKL-----DLSWCGGFGNVSPTEFKKFLTQRGDNLTHLRLNSCKFLNASC 438
            |..|:..|.::...|::|     |||       :.|      :|.....|..|.|:||:.
Mouse   113 SPALMRALGQKCPNLKRLCLHVADLS-------MVP------ITSLPSTLRTLELHSCEI----- 159

  Fly   439 IENVGIVCDNLIELSLRNCATEPPLL--------------NFSCLANLKNLERLDLFQTYFETEL 489
                     ::|.|......|..|||              :...|...:.|..|.|..||..||.
Mouse   160 ---------SMIWLQKEQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTET 215

  Fly   490 -LLSMLEGNRKLKHLNLAFCGVSVNMDNVAAHLATYNTQLISLDLWKAHFLSSRGLQSLARLHQL 553
             |.:.|:....|:.|.:..|.:|.:...:|......:.:.|.|.:..   ||::||..|..:..|
Mouse   216 GLDASLQELSYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVGG---LSAQGLVFLEGMPVL 277

  Fly   554 EELDLGWCMREASLGDGL---FQLLSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGI 615
            |.|    |.:...:...:   .|::|:|..:.||.:..|:|        :...|:..|::...|
Mouse   278 ESL----CFQGPLITPDMPTPTQIVSSCLTMPKLRVLEVQG--------LGWEGQEAEKILCKG- 329

  Fly   616 LNITHERVYDILVNCPK 632
              :.|..|  |:..|||
Mouse   330 --LPHCIV--IVRACPK 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689
		leucine-rich repeat	393..422	CDD:275381	7/33 (21%)
		leucine-rich repeat	423..442	CDD:275381	5/18 (28%)
		LRR_RI	437..>641	CDD:238064	48/214 (22%)
		leucine-rich repeat	449..474	CDD:275381	7/38 (18%)
		leucine-rich repeat	475..499	CDD:275381	9/24 (38%)
		leucine-rich repeat	500..527	CDD:275381	5/26 (19%)
		leucine-rich repeat	528..552	CDD:275381	7/23 (30%)
		AMN1	552..>660	CDD:187754	20/84 (24%)
		leucine-rich repeat	553..580	CDD:275381	7/29 (24%)
		leucine-rich repeat	581..606	CDD:275381	5/24 (21%)
		leucine-rich repeat	607..632	CDD:275381	6/24 (25%)
		leucine-rich repeat	633..652	CDD:275381	63/277 (23%)
Fbxl12	NP_001273458.1	F-box-like	<51..73	CDD:289689
		leucine-rich repeat	127..148	CDD:275381	7/33 (21%)
		AMN1	144..>249	CDD:187754	26/118 (22%)
		leucine-rich repeat	149..175	CDD:275381	8/39 (21%)
		leucine-rich repeat	176..200	CDD:275381	2/23 (9%)
		leucine-rich repeat	201..226	CDD:275381	9/24 (38%)
		leucine-rich repeat	227..252	CDD:275381	5/24 (21%)
		leucine-rich repeat	253..276	CDD:275381	7/25 (28%)
		leucine-rich repeat	277..306	CDD:275381	7/32 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900