DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fbxl4 and Fbxl6

DIOPT Version :9

Sequence 1:NP_572951.1 Gene:Fbxl4 / 32378 FlyBaseID:FBgn0030555 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_038937.2 Gene:Fbxl6 / 30840 MGIID:1354705 Length:535 Species:Mus musculus


Alignment Length:535 Identity:115/535 - (21%)
Similarity:171/535 - (31%) Gaps:176/535 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   245 LAKQQITQHSRTLVSPPPDAIGSTSGD---------GSGGSISHKLRTLKFQPNCGEDGATKLHE 300
            :|.:::.:..|:  |..|||.|.::.|         |||..:......|...|:. |....:.|.
Mouse     4 VASRRVRRRVRS--SKRPDARGRSAEDWWWDRLAPRGSGYHLLQADSMLLVLPDL-EPPRARAHR 65

  Fly   301 FINNDLSQFLADNCVDGEAAA--------PQICLTD---------LPFEILLRILSYL-----DL 343
            .......:.||    .|..|.        |:..|..         :|.|:|:.|...|     .:
Mouse    66 RARRRAPRSLA----RGPTAVAKPRTKPRPEPSLDQGLDSGWGDRIPLEVLVHIFGLLVAAHGPM 126

  Fly   344 KSLFRVGHVSRTFYDISRHPLLYAEISLKPYWDVASSELLCTLARRATMLRKLDLSWCGGFGNVS 408
            ..|.|...|.|.:::.:.||.|:..::|.|           :|..||            |.||:.
Mouse   127 PFLGRAARVCRHWHEATSHPSLWHTVTLSP-----------SLVGRA------------GKGNLK 168

  Fly   409 PTEFKKFLT-------QRGDNLTHLRLNSCKFLNASCIENVGIVCDNLIELSLRNCATEPP---- 462
            ..  ||.|.       .|...|..|.|...|....|.:|.|...|..|..|.|.:|.|...    
Mouse   169 GE--KKLLACLEWLVPNRFSQLQSLTLIHWKSQVHSVLELVSKFCPRLTFLKLSDCHTVTAETLV 231

  Fly   463 LLNFSCLANLKNLERLDLFQTYFETELLLSMLE--GNRKLK----------------------HL 503
            :|..:|.    .|..|||..:..|:..::|.||  |:|..|                      .|
Mouse   232 MLARACC----QLHSLDLHHSMVESTAVVSFLEEAGSRMRKLWLTYSSQTTAILGALLDNCCPQL 292

  Fly   504 NLAFCGVSVNMDNVAAHLATYNTQ----------LISLDLW------------------------ 534
            .:......:|.:|....|.....|          |::| :|                        
Mouse   293 QVLQVSTGMNCNNTPLQLPVEALQKGCPQLQVLRLLNL-IWLPKPCGRGVPQGPGFPSLEELCLA 356

  Fly   535 --KAHFLSSRGL-QSLARLHQLEELDLGWCMREASLG--------------------DGLFQLLS 576
              ..:|:|:..| :.|.|..:|..|||..|.|....|                    |||.....
Mouse   357 GSTCNFVSNEVLGRLLHRSPKLRMLDLRGCARVTPSGLCHLPCQELEQLYLGLYGISDGLTLAKD 421

  Fly   577 NCPKLKKLFLSAVR-------GTTERDLMHIAA--------LGKNLEQLDLMGILNITHERVYDI 626
            ..|.|.:.:...:|       |.:|:||....|        |...|..|:|.| ..:|...|..:
Mouse   422 GSPLLTRKWYHTLRELDFSGQGFSEKDLEQALAVFSGTPGGLHPALCSLNLRG-TRVTPSTVSSV 485

  Fly   627 LVNCPKLQLLDLSFC 641
            :..||.|..|:|..|
Mouse   486 ISGCPGLLYLNLESC 500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fbxl4NP_572951.1 F-box-like 326..372 CDD:289689 13/59 (22%)
leucine-rich repeat 393..422 CDD:275381 7/35 (20%)
leucine-rich repeat 423..442 CDD:275381 6/18 (33%)
LRR_RI 437..>641 CDD:238064 65/303 (21%)
leucine-rich repeat 449..474 CDD:275381 7/28 (25%)
leucine-rich repeat 475..499 CDD:275381 9/25 (36%)
leucine-rich repeat 500..527 CDD:275381 5/48 (10%)
leucine-rich repeat 528..552 CDD:275381 8/50 (16%)
AMN1 552..>660 CDD:187754 31/125 (25%)
leucine-rich repeat 553..580 CDD:275381 10/46 (22%)
leucine-rich repeat 581..606 CDD:275381 8/39 (21%)
leucine-rich repeat 607..632 CDD:275381 7/24 (29%)
leucine-rich repeat 633..652 CDD:275381 4/9 (44%)
Fbxl6NP_038937.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25 7/22 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 61..99 7/41 (17%)
F-box-like 105..155 CDD:289689 12/49 (24%)
LRR 1 169..195 7/27 (26%)
AMN1 171..390 CDD:187754 49/223 (22%)
leucine-rich repeat 188..213 CDD:275381 8/24 (33%)
LRR 2 196..221 8/24 (33%)
leucine-rich repeat 214..239 CDD:275381 7/28 (25%)
LRR 3 222..247 8/28 (29%)
leucine-rich repeat 240..291 CDD:275381 11/50 (22%)
LRR 4 273..299 1/25 (4%)
leucine-rich repeat 292..321 CDD:275381 5/28 (18%)
LRR 5 304..329 4/24 (17%)
leucine-rich repeat 322..349 CDD:275381 3/27 (11%)
LRR 6 330..357 2/27 (7%)
AMN1 <349..500 CDD:187754 35/151 (23%)
leucine-rich repeat 350..377 CDD:275381 5/26 (19%)
LRR 7 360..385 9/24 (38%)
leucine-rich repeat 378..401 CDD:275381 7/22 (32%)
LRR 8 386..411 3/24 (13%)
LRR 9 415..441 5/25 (20%)
leucine-rich repeat 434..466 CDD:275381 7/31 (23%)
leucine-rich repeat 467..491 CDD:275381 7/24 (29%)
LRR 10 474..499 8/25 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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