DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fbxl4 and Fbxo39

DIOPT Version :9

Sequence 1:NP_572951.1 Gene:Fbxl4 / 32378 FlyBaseID:FBgn0030555 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_001034107.1 Gene:Fbxo39 / 303287 RGDID:1311464 Length:443 Species:Rattus norvegicus


Alignment Length:451 Identity:96/451 - (21%)
Similarity:143/451 - (31%) Gaps:145/451 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   316 DGEAAAP--QICLTDLPFEILLRILSYLDLKSLFRVGHVSRTFYDI--------------SRHP- 363
            |.|...|  |.|...||...|.|:..:|..:...|...|.|.:..|              |..| 
  Rat     4 DSEVTQPQDQSCWATLPDVCLRRVFWWLGDRDRSRAALVCRKWNQIMYSADLWRYRTITFSGRPS 68

  Fly   364 --------------------LLYAEIS-LKPY-------WDVASSELLCTLARRATMLRKLD--- 397
                                |.:.||. |.||       :.|....||..|.:....||.|.   
  Rat    69 RVHASEFESALWYVKKFGRYLEHLEIKFLNPYNAVLTKKFQVTMRGLLSCLGKSNNRLRSLSIQH 133

  Fly   398 -----LSWCGGFGNVSPTEFKKFLTQRGDNLTHLRLNSCKFLNASCIENVGIVCDNLIELSLRNC 457
                 |.|..............||.:.|.:|.||.|...:.    .:|....:.::|..:...|.
  Rat   134 LELDRLVWRNSIRGSLIKSLSFFLKKMGKHLDHLSLKGARL----TVEQGCHILNSLSYMRNENV 194

  Fly   458 ATEPPLLNF--------------SCLANLKNLERLDLFQTYFETELLLSMLEGNRKLKHLNLAFC 508
            |:|..:.:|              ..:|...||..|.|.......|||.::.|.|          .
  Rat   195 ASELNIEDFFSHHLAVYGSSQFNKAMATFHNLTFLTLNYNCISDELLETLSENN----------A 249

  Fly   509 GVSVNMDNVAAHLATYNTQLISLDLW----------KAHFLSSRGL--QSLARLHQLEEL----- 556
            |....| |:..|:...:.|::....|          |.:|...|.:  :.|||: .|:|:     
  Rat   250 GTLRTM-NIKCHVHDPHGQVVWGMSWAKLARQASNLKVNFFFERVMKYERLARI-LLQEIPVRSI 312

  Fly   557 --------DLGWCMREASLGDGLFQLLSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLM 613
                    |..|.||               |.|..| |...|.|.::....   ...|.|.||  
  Rat   313 SLRSCYFSDPDWSMR---------------PTLTDL-LPTFRNTLQKLTFE---FNNNHESLD-- 356

  Fly   614 GILNITHERVYDILVNCPKL------QLLDLSFCDNIMDRDFDLLAEWS-RQFKVDIKSSR 667
                   |:::.:::.|.||      ..||:.|.:.|:....:  .:.| |..||.|.::|
  Rat   357 -------EQLHLLILACRKLFYFKIWAFLDVKFVERILKSQEE--GQCSLRTLKVRIYTNR 408

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fbxl4NP_572951.1 F-box-like 326..372 CDD:289689 14/81 (17%)
leucine-rich repeat 393..422 CDD:275381 8/36 (22%)
leucine-rich repeat 423..442 CDD:275381 5/18 (28%)
LRR_RI 437..>641 CDD:238064 50/248 (20%)
leucine-rich repeat 449..474 CDD:275381 6/38 (16%)
leucine-rich repeat 475..499 CDD:275381 8/23 (35%)
leucine-rich repeat 500..527 CDD:275381 4/26 (15%)
leucine-rich repeat 528..552 CDD:275381 7/35 (20%)
AMN1 552..>660 CDD:187754 26/127 (20%)
leucine-rich repeat 553..580 CDD:275381 6/39 (15%)
leucine-rich repeat 581..606 CDD:275381 5/24 (21%)
leucine-rich repeat 607..632 CDD:275381 5/24 (21%)
leucine-rich repeat 633..652 CDD:275381 5/24 (21%)
Fbxo39NP_001034107.1 F-box-like 16..57 CDD:403981 9/40 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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