DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and Fbxl4

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_766576.1	Gene:	Fbxl4 / 269514	MGIID:	2140367	Length:	621	Species:	Mus musculus

Alignment Length:	625	Identity:	207/625 - (33%)
Similarity:	305/625 - (48%)	Gaps:	83/625 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 QYVLGVLDFSSQYGIDYSISYTAANVIGRPTKFPAYGDYPETFPMRTYGDWWQRAPSATREIQPQ 130
            ||...|:||||.||.:.|:|||..|:.|.|..||:.||:.:|...||||.||.:.|||
Mouse    53 QYAKEVVDFSSHYGSENSMSYTMWNLAGVPNVFPSSGDFTQTAVFRTYGTWWDQCPSA------- 110

  Fly   131 NLP------KLETHDYVVVYFEEFVVPTEVAIFETFNPGAVVRIWAYGLTK---------NWTCL 180
            :||      ..::.|||.:.||:.|.||.|.:.||::||||:||.|.....         .|..|
Mouse   111 SLPFRRTPSSFQSQDYVELTFEQQVYPTAVHVLETYHPGAVIRILACSANPYSPNPPAEVRWEIL 175

  Fly   181 WEATESDLSRPPPLD---SRRFAPSLKKTTMLTKTLRIDFNHSRLNYYTEIDAIMLCGRTVTKTQ 242
            |.      .||..::   :|:|.|.:|:....|..:|::.|.|.|:||||:||::|.|   ||.:
Mouse   176 WS------ERPMKVNASQARQFKPCIKQINFPTNLIRLEVNSSLLDYYTELDAVVLHG---TKDK 231

  Fly   243 NLLAKQQITQHSRTLVSPPPDAIGSTSGDGSGGSISHKLRTLKFQPNCGEDGATKLHEFINNDLS 307
            .||:                                  |:|.....|..||     .::...|..
Mouse   232 PLLS----------------------------------LKTALVDMNDLED-----DDYEEKDGC 257

  Fly   308 QFLADNCVDGEAA---APQICLTD-LPFEILLRILSYLDLKSLFRVGHVSRTFYDISRHPLLYAE 368
            :..|.|.....||   .|.....| ||:|::..||::|.|..|.|:....|..:.....||.|..
Mouse   258 EMDALNKKFSSAALGDGPHNGYFDKLPYELIQLILNHLSLPDLCRLAQTCRLLHQHCCDPLQYIH 322

  Fly   369 ISLKPYWDVASSELLCTLARRATMLRKLDLSWCGGFGNVSPTEFKKFLTQRGDNLTHLRLNSCKF 433
            ::|:|||.......|..|..|..:::.|:|||.|..|.:|.:.|.:||...|..|..|.|:...|
Mouse   323 LNLQPYWARLDDTSLEFLQARCVLVQWLNLSWTGNRGFISVSGFSRFLKVCGSELVRLELSCSHF 387

  Fly   434 LNASCIENVGIVCDNLIELSLRNCATEPPLLNFSCLANLKNLERLDLFQTYFETELLLSMLEGNR 498
            ||.:|:|.:..:|.||.:|:|.:|...||.. |..:|.|.:|:||.|::|..|...|||:|....
Mouse   388 LNDTCLEVISEMCPNLQDLNLSSCDKLPPQA-FGHIAKLCSLKRLVLYRTKVEQTALLSILNFCA 451

  Fly   499 KLKHLNLAFCGVSVNMDNVAAHLATYNTQLISLDLWKAHFLSSRGLQSLAR-LHQLEELDLGWCM 562
            :|:||:|..|.:..:.|.:|:.:......|.:||||:...::..|:..||. ...|||||||||.
Mouse   452 ELQHLSLGSCVMIEDYDVIASMIGAKCKNLRTLDLWRCKNITENGIAELASGCVLLEELDLGWCP 516

  Fly   563 REASLGDGLFQLLSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGILNITHERVYDIL 627
            ...|......:|....|.|:||||:|.|...:.|:..:|:....|:|||::|...::...:..:|
Mouse   517 TLQSSTGCFVRLARQLPNLQKLFLTANRSVCDTDIEELASNCTRLQQLDILGTRMVSPASLRKLL 581

  Fly   628 VNCPKLQLLDLSFCDNIMDRDFDLLAEWSRQF-KVDIKSS 666
            .:|..|.|||:|||..|   |...:.|.:..| ||.||.|
Mouse   582 ESCKDLSLLDVSFCSQI---DNKAVLELNASFPKVFIKKS 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	14/46 (30%)
		leucine-rich repeat	393..422	CDD:275381	11/28 (39%)
		leucine-rich repeat	423..442	CDD:275381	8/18 (44%)
		LRR_RI	437..>641	CDD:238064	71/204 (35%)
		leucine-rich repeat	449..474	CDD:275381	9/24 (38%)
		leucine-rich repeat	475..499	CDD:275381	10/23 (43%)
		leucine-rich repeat	500..527	CDD:275381	7/26 (27%)
		leucine-rich repeat	528..552	CDD:275381	8/24 (33%)
		AMN1	552..>660	CDD:187754	39/108 (36%)
		leucine-rich repeat	553..580	CDD:275381	11/26 (42%)
		leucine-rich repeat	581..606	CDD:275381	9/24 (38%)
		leucine-rich repeat	607..632	CDD:275381	7/24 (29%)
		leucine-rich repeat	633..652	CDD:275381	9/18 (50%)
Fbxl4	NP_766576.1	F-box-like	280..318	CDD:372399	9/41 (22%)
		leucine-rich repeat	295..317	CDD:275381	6/25 (24%)
		leucine-rich repeat	318..340	CDD:275381	7/21 (33%)
		leucine-rich repeat	347..376	CDD:275381	9/28 (32%)
		LRR 1	376..397		8/20 (40%)
		leucine-rich repeat	377..402	CDD:275381	8/24 (33%)
		AMN1	394..601	CDD:187754	74/207 (36%)
		LRR 2	402..421		6/18 (33%)
		leucine-rich repeat	403..427	CDD:275381	9/23 (39%)
		LRR 3	427..448		7/20 (35%)
		leucine-rich repeat	428..452	CDD:275381	8/23 (35%)
		LRR 4	452..474		8/21 (38%)
		leucine-rich repeat	453..480	CDD:275381	11/26 (42%)
		LRR 5	480..501		6/20 (30%)
		leucine-rich repeat	481..506	CDD:275381	7/24 (29%)
		LRR 6	504..524		6/19 (32%)
		leucine-rich repeat	507..534	CDD:275381	6/26 (23%)
		LRR 7	532..558		12/26 (46%)
		leucine-rich repeat	535..560	CDD:275381	11/25 (44%)
		LRR 8	559..583		9/23 (39%)
		leucine-rich repeat	561..586	CDD:275381	10/24 (42%)
		LRR 9	584..609		6/24 (25%)
		leucine-rich repeat	587..612	CDD:275381	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842370
Domainoid	1	1.000	161	1.000	Domainoid score	I4008
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8128
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2816
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50183
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003673
OrthoInspector	1	1.000	-	-		oto94805
orthoMCL	1	0.900	-	-		OOG6_108781
Panther	1	1.100	-	-	LDO	PTHR13318
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5732
SonicParanoid	1	1.000	-	-		X7198
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790