DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fbxl4 and FBXL4

DIOPT Version :9

Sequence 1:NP_572951.1 Gene:Fbxl4 / 32378 FlyBaseID:FBgn0030555 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_001265645.1 Gene:FBXL4 / 26235 HGNCID:13601 Length:621 Species:Homo sapiens


Alignment Length:644 Identity:209/644 - (32%)
Similarity:310/644 - (48%) Gaps:91/644 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 DSKMQTTQSDQGYYLEQYVLGVLDFSSQYGIDYSISYTAANVIGRPTKFPAYGDYPETFPMRTYG 114
            :|..||  |.....:.||...|:||||.||.:.|:|||..|:.|.|..||:.||:.:|...||||
Human    39 ESNSQT--SPLNAEVVQYAKEVVDFSSHYGSENSMSYTMWNLAGVPNVFPSSGDFTQTAVFRTYG 101

  Fly   115 DWWQRAPSATREIQPQNLPKLETHDYVVVYFEEFVVPTEVAIFETFNPGAVVRIWAYGLTK---- 175
            .||.:.|||:...: :..|..::.|||.:.||:.|.||.|.:.||::||||:||.|.....    
Human   102 TWWDQCPSASLPFK-RTPPNFQSQDYVELTFEQQVYPTAVHVLETYHPGAVIRILACSANPYSPN 165

  Fly   176 -----NWTCLWEATESDLSRPPPLD---SRRFAPSLKKTTMLTKTLRIDFNHSRLNYYTEIDAIM 232
                 .|..||.      .||..::   :|:|.|.:|:....|..:|::.|.|.|.||||:||::
Human   166 PPAEVRWEILWS------ERPTKVNASQARQFKPCIKQINFPTNLIRLEVNSSLLEYYTELDAVV 224

  Fly   233 LCG----RTVTKTQNLLAKQQITQHSRTLVSPPPDAIGSTSGDGSGGSISHKLRTLKFQPNCGED 293
            |.|    ..::...:|:....|..          ||.....|                   ||.|
Human   225 LHGVKDKPVLSLKTSLIDMNDIED----------DAYAEKDG-------------------CGMD 260

  Fly   294 GATK------LHEFINNDLSQFLADNCVDGEAAAPQICLTDLPFEILLRILSYLDLKSLFRVGHV 352
            ...|      |.|..||..                   ...||:|::..||::|.|..|.|:...
Human   261 SLNKKFSSAVLGEGPNNGY-------------------FDKLPYELIQLILNHLTLPDLCRLAQT 306

  Fly   353 SRTFYDISRH---PLLYAEISLKPYWDVASSELLCTLARRATMLRKLDLSWCGGFGNVSPTEFKK 414
            .:.   :|:|   ||.|..::|:|||.......|..|..|.|:::.|:|||.|..|.:|...|.:
Human   307 CKL---LSQHCCDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSR 368

  Fly   415 FLTQRGDNLTHLRLNSCKFLNASCIENVGIVCDNLIELSLRNCATEPPLLNFSCLANLKNLERLD 479
            ||...|..|..|.|:...|||.:|:|.:..:|.||..|:|.:|...||.. |:.:|.|.:|:||.
Human   369 FLKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQA-FNHIAKLCSLKRLV 432

  Fly   480 LFQTYFETELLLSMLEGNRKLKHLNLAFCGVSVNMDNVAAHLATYNTQLISLDLWKAHFLSSRGL 544
            |::|..|...|||:|....:|:||:|..|.:..:.|.:|:.:.....:|.:||||:...::..|:
Human   433 LYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGI 497

  Fly   545 QSLAR-LHQLEELDLGWCMREASLGDGLFQLLSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLE 608
            ..||. ...|||||||||....|......:|....|.|:||||:|.|...:.|:..:|.....|:
Human   498 AELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQ 562

  Fly   609 QLDLMGILNITHERVYDILVNCPKLQLLDLSFCDNIMDRDFDLLAEWSRQF-KVDIKSS 666
            |||::|...::...:..:|.:|..|.|||:|||..|.:|   .:.|.:..| ||.||.|
Human   563 QLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNR---AVLELNASFPKVFIKKS 618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fbxl4NP_572951.1 F-box-like 326..372 CDD:289689 14/48 (29%)
leucine-rich repeat 393..422 CDD:275381 11/28 (39%)
leucine-rich repeat 423..442 CDD:275381 8/18 (44%)
LRR_RI 437..>641 CDD:238064 71/204 (35%)
leucine-rich repeat 449..474 CDD:275381 9/24 (38%)
leucine-rich repeat 475..499 CDD:275381 10/23 (43%)
leucine-rich repeat 500..527 CDD:275381 7/26 (27%)
leucine-rich repeat 528..552 CDD:275381 8/24 (33%)
AMN1 552..>660 CDD:187754 39/108 (36%)
leucine-rich repeat 553..580 CDD:275381 11/26 (42%)
leucine-rich repeat 581..606 CDD:275381 9/24 (38%)
leucine-rich repeat 607..632 CDD:275381 7/24 (29%)
leucine-rich repeat 633..652 CDD:275381 9/18 (50%)
FBXL4NP_001265645.1 F-box-like 280..318 CDD:315592 11/40 (28%)
leucine-rich repeat 295..317 CDD:275381 6/24 (25%)
leucine-rich repeat 318..346 CDD:275381 9/27 (33%)
leucine-rich repeat 347..376 CDD:275381 11/28 (39%)
LRR 1 376..397 8/20 (40%)
leucine-rich repeat 377..398 CDD:275381 8/20 (40%)
AMN1 394..601 CDD:332986 73/207 (35%)
LRR 2 402..421 8/19 (42%)
leucine-rich repeat 403..427 CDD:275381 9/24 (38%)
LRR 3 427..448 9/20 (45%)
leucine-rich repeat 428..452 CDD:275381 10/23 (43%)
LRR 4 452..474 7/21 (33%)
leucine-rich repeat 453..480 CDD:275381 7/26 (27%)
LRR 5 480..501 6/20 (30%)
leucine-rich repeat 481..506 CDD:275381 8/24 (33%)
LRR 6 504..524 10/19 (53%)
leucine-rich repeat 507..534 CDD:275381 11/26 (42%)
LRR 7 532..558 10/25 (40%)
leucine-rich repeat 535..560 CDD:275381 9/24 (38%)
LRR 8 559..583 6/23 (26%)
leucine-rich repeat 561..586 CDD:275381 7/24 (29%)
LRR 9 584..609 11/27 (41%)
leucine-rich repeat 587..612 CDD:275381 11/27 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152302
Domainoid 1 1.000 163 1.000 Domainoid score I3982
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H8128
Inparanoid 1 1.050 290 1.000 Inparanoid score I2821
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG50183
OrthoDB 1 1.010 - - D298796at33208
OrthoFinder 1 1.000 - - FOG0003673
OrthoInspector 1 1.000 - - oto91225
orthoMCL 1 0.900 - - OOG6_108781
Panther 1 1.100 - - LDO PTHR13318
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5732
SonicParanoid 1 1.000 - - X7198
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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