DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fbxl4 and FBXL6

DIOPT Version :9

Sequence 1:NP_572951.1 Gene:Fbxl4 / 32378 FlyBaseID:FBgn0030555 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_036294.2 Gene:FBXL6 / 26233 HGNCID:13603 Length:539 Species:Homo sapiens


Alignment Length:430 Identity:94/430 - (21%)
Similarity:145/430 - (33%) Gaps:153/430 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   329 LPFEILLRILSYL-----DLKSLFRVGHVSRTFYDISRHPLLYAEISL------KPYWD--VASS 380
            :|.|||::|...|     .:..|.|...|.|.:.:.:..|.|:..::|      :|...  .|..
Human   115 IPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTVTLSSPLVGRPAKGGVKAEK 179

  Fly   381 ELLCTL----ARRATMLRKLDL-SWCGGFGNVSPTEFKKFLTQRGDNLTHLRLNSCKFLNASCIE 440
            :||.:|    ..|.:.|::|.| .|   ...|.|.  .|.:.:....||.|:|:.|.        
Human   180 KLLASLEWLMPNRFSQLQRLTLIHW---KSQVHPV--LKLVGECCPRLTFLKLSGCH-------- 231

  Fly   441 NVGIVCDNLIELSLRNCATEPPLLNFSCLANLKNLERLDLFQTYFETELLLSMLE--GNRKLK-- 501
              |:..|.|:.|:...|                .|..|||..:..|:..::|.||  |:|..|  
Human   232 --GVTADALVMLAKACC----------------QLHSLDLQHSMVESTAVVSFLEEAGSRMRKLW 278

  Fly   502 --------------------HLNLAFCGVSVNMDNVAAHLATYNTQ----------LISLDLW-- 534
                                .|.:......:|.:::...|.....|          |::| :|  
Human   279 LTYSSQTTAILGALLGSCCPQLQVLEVSTGINRNSIPLQLPVEALQKGCPQLQVLRLLNL-MWLP 342

  Fly   535 ------------------------KAHFLSSRGLQSLARLH---QLEELDLGWCMR--EASLGD- 569
                                    ..:|:|:..|..|  ||   .|..|||..|.|  .|.|.| 
Human   343 KPPGRGVAPGPGFPSLEELCLASSTCNFVSNEVLGRL--LHGSPNLRLLDLRGCARITPAGLQDL 405

  Fly   570 ----------GLFQLLSN---------------CPKLKKLFLSAVRGTTERDLMHIAAL------ 603
                      ||:.....               |..|::|.||. :|.:|:||....|.      
Human   406 PCRELEQLHLGLYGTSDRLTLAKEGSPFLTQKWCHTLRELDLSG-QGFSEKDLEQALAAFLSTPG 469

  Fly   604 GKN--LEQLDLMGILNITHERVYDILVNCPKLQLLDLSFC 641
            |.:  |..|:|.| ..:|...|..::..||.|..|:|..|
Human   470 GSHPALCSLNLRG-TRVTPSTVSSVISGCPGLLYLNLESC 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fbxl4NP_572951.1 F-box-like 326..372 CDD:289689 13/53 (25%)
leucine-rich repeat 393..422 CDD:275381 7/29 (24%)
leucine-rich repeat 423..442 CDD:275381 5/18 (28%)
LRR_RI 437..>641 CDD:238064 62/302 (21%)
leucine-rich repeat 449..474 CDD:275381 3/24 (13%)
leucine-rich repeat 475..499 CDD:275381 9/25 (36%)
leucine-rich repeat 500..527 CDD:275381 4/48 (8%)
leucine-rich repeat 528..552 CDD:275381 9/52 (17%)
AMN1 552..>660 CDD:187754 34/126 (27%)
leucine-rich repeat 553..580 CDD:275381 12/54 (22%)
leucine-rich repeat 581..606 CDD:275381 10/30 (33%)
leucine-rich repeat 607..632 CDD:275381 7/24 (29%)
leucine-rich repeat 633..652 CDD:275381 4/9 (44%)
FBXL6NP_036294.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 49..111
F-box-like 113..163 CDD:289689 12/47 (26%)
LRR 1 177..203 8/25 (32%)
AMN1 185..398 CDD:187754 49/246 (20%)
leucine-rich repeat 196..221 CDD:275381 7/29 (24%)
LRR 2 204..229 8/29 (28%)
leucine-rich repeat 222..247 CDD:275381 10/50 (20%)
LRR 3 230..255 10/50 (20%)
leucine-rich repeat 248..299 CDD:275381 11/50 (22%)
LRR 4 281..307 1/25 (4%)
leucine-rich repeat 300..329 CDD:275381 4/28 (14%)
LRR 5 312..337 3/24 (13%)
leucine-rich repeat 330..357 CDD:275381 3/27 (11%)
LRR 6 341..365 0/23 (0%)
AMN1 <357..508 CDD:187754 39/154 (25%)
leucine-rich repeat 358..385 CDD:275381 6/28 (21%)
LRR 7 368..393 10/26 (38%)
leucine-rich repeat 386..409 CDD:275381 9/22 (41%)
LRR 8 394..419 7/24 (29%)
LRR 9 423..449 4/25 (16%)
leucine-rich repeat 442..474 CDD:275381 10/32 (31%)
LRR 10 453..481 7/27 (26%)
leucine-rich repeat 475..499 CDD:275381 7/24 (29%)
LRR 11 482..507 8/25 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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