DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and Lrrc29

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001355337.1	Gene:	Lrrc29 / 234684	MGIID:	2443262	Length:	621	Species:	Mus musculus

Alignment Length:	524	Identity:	125/524 - (23%)
Similarity:	191/524 - (36%)	Gaps:	174/524 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 DGATKLHEFINN---DLSQFLADNCVDGEAAAPQICLTDLPFEILL---RILSYLDL---KSLFR 348
            ||:...|:.:.:   .|...|...|:.|  .:|    |:..|..|:   .:|..|||   .|||.
Mouse    76 DGSPASHQVLQSVAYHLGPHLESLCLGG--GSP----TEASFLALILGCPVLRTLDLSGCNSLFT 134

  Fly   349 VG------------------------------------HVSRTFYDISRHPLLYAEIS--LKPYW 375
            .|                                    |:|..|..:.|..|.|..:|  |.|.|
Mouse   135 SGTLLAQPETAQCVREALSGLRDLNLAGLRDLTDLSFNHLSSCFPSLERLSLAYCHLSFELSPTW 199

  Fly   376 DVASSE-----------LLCTLARRATMLRKLDLSWCGGFGNVSPTEFKKFLTQ-RGDNLTHLRL 428
            ...|.:           ||..:..||..||.||||     |...|.|..:.|.| .|..|..|.|
Mouse   200 GSISPQVSSPSQLSFHNLLKFIKERAGTLRALDLS-----GTGLPPEALQALGQVTGLKLEELYL 259

  Fly   429 NSCKFLNASCIENVGIVC---DNLIELSLRNCA--TEPPLLNFS--------------------- 467
            :||:.|::   |.|.|:|   ..|..|.|..|:  |:..||..|
Mouse   260 HSCRDLSS---EAVTILCRQQPGLTSLDLSGCSDLTDGALLAVSRGLRHLRHLSLKKLQRLTDAG 321

  Fly   468 --CLANLKNLERLDLFQTYFET-----ELLLSMLEGNRKLKHLNLAFC---------------GV 510
              .|..|:.|:.||:.:....:     ::|.|:....|.|..|.||:|               |.
Mouse   322 CAALGALRELQSLDMAECCLVSGRELAQVLGSVRRAPRALTSLRLAYCSSLKDASVLSMIPALGP 386

  Fly   511 SVNMDNVAAHLATYN-------TQLISLDLWKAHF---LSSRGLQSL----------ARLHQ--- 552
            |:.:.::::.:|..|       |.||.|.:.:..:   |...||..|          .:|||
Mouse   387 SLKVLDLSSCMALTNQTMQAICTYLIHLSVLRLAWCKELQDWGLLGLKEPSDEPVLSPQLHQKVD 451

  Fly   553 -----------------------LEELDLGWC--MREASLGDGLFQLLSNCPKLKKLFLSAVRGT 592
                                   |:||||..|  :.:|||...|     ..|:|::|.||.:...
Mouse   452 NEAPDPQEPSSEPQGSSLLMLQALQELDLTACSKLTDASLAKVL-----QFPQLRQLSLSLLPAF 511

  Fly   593 TERDLMHIAALGKNLEQLDLMGILNITHERVYDILVNCPKLQLLDLSFCDNIMDRDFDLLAEWSR 657
            |:..|:.:|....:||:|.|....:::.|.........|:||.|:||.|..:.::..|.:.:..:
Mouse   512 TDTGLVAVARGCPSLERLTLSHCSHLSDEGWAQAARLWPRLQHLNLSSCSQLTEQTLDTIGQACK 576

  Fly   658 QFKV 661
            |.:|
Mouse   577 QLRV 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	18/89 (20%)
		leucine-rich repeat	393..422	CDD:275381	12/29 (41%)
		leucine-rich repeat	423..442	CDD:275381	7/18 (39%)
		LRR_RI	437..>641	CDD:238064	69/299 (23%)
		leucine-rich repeat	449..474	CDD:275381	10/49 (20%)
		leucine-rich repeat	475..499	CDD:275381	5/28 (18%)
		leucine-rich repeat	500..527	CDD:275381	9/48 (19%)
		leucine-rich repeat	528..552	CDD:275381	8/36 (22%)
		AMN1	552..>660	CDD:187754	33/135 (24%)
		leucine-rich repeat	553..580	CDD:275381	10/28 (36%)
		leucine-rich repeat	581..606	CDD:275381	7/24 (29%)
		leucine-rich repeat	607..632	CDD:275381	5/24 (21%)
		leucine-rich repeat	633..652	CDD:275381	7/18 (39%)
Lrrc29	NP_001355337.1	F-box-like	3..38	CDD:372399
		leucine-rich repeat	70..83	CDD:275381	2/6 (33%)
		LRR_RI	<118..360	CDD:393385	60/249 (24%)
		leucine-rich repeat	121..154	CDD:275381	8/32 (25%)
		leucine-rich repeat	155..180	CDD:275381	3/24 (13%)
		leucine-rich repeat	181..227	CDD:275381	12/45 (27%)
		leucine-rich repeat	228..248	CDD:275381	10/24 (42%)
		AMN1	240..428	CDD:187754	44/190 (23%)
		leucine-rich repeat	254..277	CDD:275381	10/25 (40%)
		leucine-rich repeat	280..305	CDD:275381	8/24 (33%)
		leucine-rich repeat	306..360	CDD:275381	7/53 (13%)
		leucine-rich repeat	331..356	CDD:275381	5/24 (21%)
		leucine-rich repeat	361..387	CDD:275381	6/25 (24%)
		leucine-rich repeat	388..413	CDD:275381	4/24 (17%)
		leucine-rich repeat	414..474	CDD:275381	8/59 (14%)
		AMN1	<475..589	CDD:187754	33/111 (30%)
		leucine-rich repeat	475..525	CDD:275381	18/54 (33%)
		leucine-rich repeat	526..551	CDD:275381	5/24 (21%)
		leucine-rich repeat	552..577	CDD:275381	7/24 (29%)
		leucine-rich repeat	578..603	CDD:275381	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810