DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and Amn1

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001106895.1	Gene:	Amn1 / 232566	MGIID:	2442933	Length:	258	Species:	Mus musculus

Alignment Length:	245	Identity:	67/245 - (27%)
Similarity:	120/245 - (48%)	Gaps:	31/245 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   428 LNSCKFLNASCIENVGIVCDNLIE-LSLRNCATEPPLLNFSCLANLKNLERLDLFQTYFETELLL 491
            ::..|:|.::       :.|.||: :|:|...|:.   |.|.:.: ..::|||| ::...:::.|
Mouse    26 ISDIKYLPSN-------IKDRLIKIMSIRGRITDS---NISEVLH-PEVQRLDL-RSCDISDVAL 78

  Fly   492 SMLEGNRKLKHLNLAFCGV---SVNMDNVAAHLATYNTQLISLDLWKAHFLSSRGLQSLA-RLHQ 552
            ..|...||||.|||..|..   |:..:.:.| :|:..:.|..:.|.....::..|:.:|| ..|.
Mouse    79 QHLCKCRKLKALNLKSCREHRNSITSEGIKA-VASSCSDLHEIYLKGCCSVTDEGVLALALNCHL 142

  Fly   553 LEELDLGWCMREASLGDGLFQLLSNCPKLKKLFLSAVRGTTERDLMHIAAL-----GKNLEQLDL 612
            |:.:|||.|:....:  .|..|..|||.|:.:.:|    ||:.....:.||     .|.||::::
Mouse   143 LKIIDLGGCLGITDV--SLHALGKNCPFLQCVDIS----TTQVSDNGVVALVSGPCAKQLEEINM 201

  Fly   613 MGILNITHERVYDILVNCPKLQLLDLSFCDNIMDRDFDLLAE--WSRQFK 660
            ...:|:|.:.|...|..||::.:|....|..|.||..::|.:  .||:.|
Mouse   202 RYCINLTDKAVEAALTACPRICILLFHGCPLITDRSQEVLEQLIGSRKLK 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689
		leucine-rich repeat	393..422	CDD:275381
		leucine-rich repeat	423..442	CDD:275381	2/13 (15%)
		LRR_RI	437..>641	CDD:238064	57/213 (27%)
		leucine-rich repeat	449..474	CDD:275381	7/25 (28%)
		leucine-rich repeat	475..499	CDD:275381	6/23 (26%)
		leucine-rich repeat	500..527	CDD:275381	9/29 (31%)
		leucine-rich repeat	528..552	CDD:275381	5/24 (21%)
		AMN1	552..>660	CDD:187754	33/114 (29%)
		leucine-rich repeat	553..580	CDD:275381	9/26 (35%)
		leucine-rich repeat	581..606	CDD:275381	6/29 (21%)
		leucine-rich repeat	607..632	CDD:275381	7/24 (29%)
		leucine-rich repeat	633..652	CDD:275381	5/18 (28%)
Amn1	NP_001106895.1	leucine-rich repeat	15..38	CDD:275381	2/18 (11%)
		AMN1	37..257	CDD:187754	65/227 (29%)
		leucine-rich repeat	63..86	CDD:275381	6/23 (26%)
		leucine-rich repeat	87..116	CDD:275381	9/29 (31%)
		leucine-rich repeat	117..142	CDD:275381	5/24 (21%)
		leucine-rich repeat	143..168	CDD:275381	9/26 (35%)
		leucine-rich repeat	169..195	CDD:275381	6/29 (21%)
		leucine-rich repeat	196..221	CDD:275381	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810