DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fbxl4 and FBXL7

DIOPT Version :9

Sequence 1:NP_572951.1 Gene:Fbxl4 / 32378 FlyBaseID:FBgn0030555 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_036436.1 Gene:FBXL7 / 23194 HGNCID:13604 Length:491 Species:Homo sapiens


Alignment Length:486 Identity:111/486 - (22%)
Similarity:180/486 - (37%) Gaps:130/486 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   237 TVTKTQNLLAKQQITQHS-RTLVSP------PPDAIGSTSGDG---SGGSISHKLRTLKFQPNCG 291
            |.||.|..:|..:.:..| |||.:|      ||:..|..:|.|   |..||:.:...:...|   
Human    30 TPTKAQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSP--- 91

  Fly   292 EDGATKL-HEFINNDLSQFLADNCVDGEAAAP---QICLTDLPFEILLRILSYLDLKSLFRVGHV 352
              ..|:| |..|.              .|:.|   |..:..||...:::|.|:|....|.|...|
Human    92 --PPTRLTHPLIR--------------LASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARV 140

  Fly   353 SRTFYDISRHPLLYAEISLKPYWDVASSELLCTLARR--------ATMLRKLDLSWCGGFGNVSP 409
            .|.:|:::..|.|:..|.|... .:.....|..|.||        ..||..:.:|.|        
Human   141 CRRWYNLAWDPRLWRTIRLTGE-TINVDRALKVLTRRLCQDTPNVCLMLETVTVSGC-------- 196

  Fly   410 TEFKKFLTQRG--------DNLTHLRLNSCKFLNASCIENVGIVCDNLIELSLRNCATEPPLLNF 466
                :.||.||        ..|..|.::.|..::...:.:|..:|.||..|.:..|:      ..
Human   197 ----RRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCS------KV 251

  Fly   467 SCLANLKNLERLDLFQTYFETELLLSMLEGNR-KLKHLNLAFCGV--SVNMDNVAAH-------- 520
            :|:    :|.|        |..:.||.|.|.: .:::|::..|.|  ...:..:|||        
Human   252 TCI----SLTR--------EASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLY 304

  Fly   521 --------------LATYNTQLISLDLWKAHFLSSRGLQSLARLH-QLEELDLGWCMREASLG-- 568
                          |..|...:..|.:....|:|..||:.:|:|. :|..|.:..|.|...:|  
Human   305 LRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIR 369

  Fly   569 ----------------------DGLFQLLSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLD 611
                                  .|:..|..||.|||.|.:......::..|..:|....||::|.
Human   370 YVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLS 434

  Fly   612 LMGILNITHERVYDILVNCPKLQLLDLSFCD 642
            |....:||.:.:..:..||..||.|::..|:
Human   435 LKSCESITGQGLQIVAANCFDLQTLNVQDCE 465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fbxl4NP_572951.1 F-box-like 326..372 CDD:289689 13/45 (29%)
leucine-rich repeat 393..422 CDD:275381 7/36 (19%)
leucine-rich repeat 423..442 CDD:275381 3/18 (17%)
LRR_RI 437..>641 CDD:238064 55/253 (22%)
leucine-rich repeat 449..474 CDD:275381 4/24 (17%)
leucine-rich repeat 475..499 CDD:275381 7/24 (29%)
leucine-rich repeat 500..527 CDD:275381 8/50 (16%)
leucine-rich repeat 528..552 CDD:275381 7/24 (29%)
AMN1 552..>660 CDD:187754 27/115 (23%)
leucine-rich repeat 553..580 CDD:275381 9/50 (18%)
leucine-rich repeat 581..606 CDD:275381 5/24 (21%)
leucine-rich repeat 607..632 CDD:275381 7/24 (29%)
leucine-rich repeat 633..652 CDD:275381 4/10 (40%)
FBXL7NP_036436.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..79 16/48 (33%)
F-box-like 114..157 CDD:372399 12/42 (29%)
leucine-rich repeat 129..151 CDD:275381 6/21 (29%)
leucine-rich repeat 154..187 CDD:275381 6/33 (18%)
LRR 1 170..195 6/24 (25%)
AMN1 <185..366 CDD:187754 44/210 (21%)
leucine-rich repeat 188..213 CDD:275381 7/36 (19%)
LRR 2 196..221 7/36 (19%)
leucine-rich repeat 214..234 CDD:275381 3/19 (16%)
LRR 3 222..247 6/24 (25%)
leucine-rich repeat 240..273 CDD:275381 11/50 (22%)
LRR 4 253..281 9/39 (23%)
leucine-rich repeat 274..299 CDD:275381 6/24 (25%)
LRR 5 282..307 5/24 (21%)
AMN1 297..464 CDD:187754 35/166 (21%)
leucine-rich repeat 300..325 CDD:275381 2/24 (8%)
LRR 6 308..333 3/24 (13%)
leucine-rich repeat 326..351 CDD:275381 7/24 (29%)
LRR 7 334..359 8/24 (33%)
leucine-rich repeat 352..377 CDD:275381 5/24 (21%)
LRR 8 360..385 3/24 (13%)
leucine-rich repeat 378..403 CDD:275381 4/24 (17%)
LRR 9 386..411 8/24 (33%)
leucine-rich repeat 404..429 CDD:275381 5/24 (21%)
LRR 10 412..437 6/24 (25%)
leucine-rich repeat 430..453 CDD:275381 5/22 (23%)
LRR 11 438..463 7/24 (29%)
leucine-rich repeat 456..480 CDD:275381 4/10 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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