DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fbxl4 and KDM2A

DIOPT Version :9

Sequence 1:NP_572951.1 Gene:Fbxl4 / 32378 FlyBaseID:FBgn0030555 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_036440.1 Gene:KDM2A / 22992 HGNCID:13606 Length:1162 Species:Homo sapiens


Alignment Length:473 Identity:104/473 - (21%)
Similarity:172/473 - (36%) Gaps:116/473 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   182 EATESDLSRPPPLDSRRFAPSLKKTTMLTKTLRIDFNHSRLNYYTEIDAIMLCGRT-VTKTQNLL 245
            :|||..:.|     .:...||.||.  |::..:.....|.|....:.....|.|.: |.|.|.:.
Human   766 QATERTMVR-----EKENNPSGKKE--LSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAIT 823

  Fly   246 AKQQITQHS-RTLVSPPPDAIGSTSGD--GSGGSISHKLRTLKFQPNCGEDGATKLHEFINNDLS 307
            |.....:|| |.||...| |.....||  |.||....:....:...:..|.||.:|:.  ....:
Human   824 ASSANLRHSPRVLVQHCP-ARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNG--RGSWA 885

  Fly   308 QFLADNCVDGEAAAPQICLTDLPFEILLRILSYLDLKSLFRVGHVSRTFYDISRHPLLYAEISLK 372
            |       ||:.:..|       .|:.:.:..||..:.|.....|.:|:|.......|:.:|.|.
Human   886 Q-------DGDESWMQ-------REVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLS 936

  Fly   373 PYWDVASSELLCTLARRATMLRKLDLSWCGGFGNVSPTEFKKFLTQRGDNLTHLRLNSCKFLNAS 437
            ....:....|...:.|:..   .|||||.    |:|..:. .:|..|...|..|.|..|.:...|
Human   937 RCKAIVPQALSGIIKRQPV---SLDLSWT----NISKKQL-TWLVNRLPGLKDLLLAGCSWSAVS 993

  Fly   438 CIEN--------------VGIVCDNLIELSLRNCATEPPLLNFSCLANLKN--LERLDLFQTYFE 486
            .:..              |||....:.:| |...|.:|...|.|.|.|:.:  |..||:      
Human   994 ALSTSSCPLLRTLDLRWAVGIKDPQIRDL-LTPPADKPGQDNRSKLRNMTDFRLAGLDI------ 1051

  Fly   487 TELLLSMLEGNRK-LKHLNLAFCGVSVNMDNVAAHLATYNTQLISLDLWKAHFLSSRGLQSLARL 550
            |:..|.::..:.. |..|:|:.|          :||...::.|::            .:.|..| 
Human  1052 TDATLRLIIRHMPLLSRLDLSHC----------SHLTDQSSNLLT------------AVGSSTR- 1093

  Fly   551 HQLEELDLGWCMREASLGDGLFQLLSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGI 615
            :.|.||:                 ::.|.||           |::.|:::..:. |:..:||.|.
Human  1094 YSLTELN-----------------MAGCNKL-----------TDQTLIYLRRIA-NVTLIDLRGC 1129

  Fly   616 LNITHER----VYDILVN 629
            ..||.:.    :.|:.:|
Human  1130 KQITRKACEHFISDLSIN 1147

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fbxl4NP_572951.1 F-box-like 326..372 CDD:289689 9/45 (20%)
leucine-rich repeat 393..422 CDD:275381 9/28 (32%)
leucine-rich repeat 423..442 CDD:275381 5/32 (16%)
LRR_RI 437..>641 CDD:238064 42/214 (20%)
leucine-rich repeat 449..474 CDD:275381 8/24 (33%)
leucine-rich repeat 475..499 CDD:275381 5/23 (22%)
leucine-rich repeat 500..527 CDD:275381 6/26 (23%)
leucine-rich repeat 528..552 CDD:275381 3/23 (13%)
AMN1 552..>660 CDD:187754 16/82 (20%)
leucine-rich repeat 553..580 CDD:275381 4/26 (15%)
leucine-rich repeat 581..606 CDD:275381 3/24 (13%)
leucine-rich repeat 607..632 CDD:275381 7/27 (26%)
leucine-rich repeat 633..652 CDD:275381
KDM2ANP_036440.1 cupin_like 199..299 CDD:328732
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 367..389
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..557
zf-CXXC <576..609 CDD:251032
PHD_KDM2A 619..675 CDD:277113
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 704..789 9/29 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 839..887 12/57 (21%)
F-box-like 896..934 CDD:315592 8/37 (22%)
leucine-rich repeat 930..954 CDD:275381 4/23 (17%)
AMN1 932..1138 CDD:332986 57/272 (21%)
leucine-rich repeat 955..978 CDD:275381 9/30 (30%)
LRR 1 961..982 6/25 (24%)
leucine-rich repeat 979..1002 CDD:275381 5/22 (23%)
LRR 2 984..1010 3/25 (12%)
leucine-rich repeat 1003..1040 CDD:275381 10/37 (27%)
leucine-rich repeat 1041..1065 CDD:275381 5/29 (17%)
LRR 3 1048..1073 7/30 (23%)
leucine-rich repeat 1066..1095 CDD:275381 9/51 (18%)
LRR 4 1074..1103 9/68 (13%)
leucine-rich repeat 1096..1120 CDD:275381 8/52 (15%)
LRR 5 1104..1128 8/35 (23%)
leucine-rich repeat 1121..1140 CDD:275381 5/18 (28%)
LRR 6 1129..1156 4/19 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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