Protein Alignment Fbxl4 and FBXL13

DIOPT Version :10

• Sequence 1: NP_572951.1
• Gene: Fbxl4 / 32378
• FlyBaseID: FBgn0030555
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_001381423.1
• Gene: FBXL13 / 222235
• HGNCID: 21658
• Length: 825
• Species: Homo sapiens
• Alignment Length: 475
• Identity: 107/475 - (22%)
• Similarity: 185/475 - (38%)
• Gaps: 112/475 - (23%)

  Fly   202 SLKKTTMLTKTLRIDFNHSRLNYYTEIDAIML--CGRTVTKTQNLLAKQQITQHSRTLVSPPPDA 264
            :|..||:..:|:|:...|     :..:..:.|  |.|...|....|
Human   367 NLSNTTITNRTMRLLPRH-----FHNLQNLSLAYCRRFTDKGLQYL------------------- 407

  Fly   265 IGSTSGDGSGGSISHKLRTLKFQPNCGE----------DGATKLHEFINNDLSQFLADNCVDGEA 319
               ..|:|     .|||..|... .|.:          :..|.:.....||:.. |.||||   .
Human   408 ---NLGNG-----CHKLIYLDLS-GCTQISVQGFRYIANSCTGIMHLTINDMPT-LTDNCV---K 459

  Fly   320 AAPQIC--LTDLPF-------EILLRILSYLDLKSL-----FRVGHVSRTFYDISRHPLLYAEIS 370
            |..:.|  :|.|.|       :...|.||...|:.:     .||...|..|.| ..:|.| :.|.
Human   460 ALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKFID-KNYPNL-SHIY 522

  Fly   371 LKPYWDVASSELLCTLARRATMLRK---LDLSWCGGFGNVSPTEFKKFLTQRGD-NLTHLRLNSC 431
            :.....:..|.|     |..:.|::   |:|:.|...|::.   .|:||..... .:..|.|::|
Human   523 MADCKGITDSSL-----RSLSPLKQLTVLNLANCVRIGDMG---LKQFLDGPASMRIRELNLSNC 579

  Fly   432 KFLNASCIENVGIVCDNLIELSLRNCATEPPLLNFSCLANLKNLERLDLFQTYFETELLLSMLEG 496
            ..|:.:.:..:...|.||..|||||| ..........:.|:.:|..:||..|....| .|::|..
Human   580 VRLSDASVMKLSERCPNLNYLSLRNC-EHLTAQGIGYIVNIFSLVSIDLSGTDISNE-GLNVLSR 642

  Fly   497 NRKLKHLNLAFCGVSVNMDNVAAHLATYNTQLISLDLWKAHFLSSRGLQSLARLHQ-LEELDLGW 560
            ::|||.|:::.|                            :.::..|:|:..:... ||.||:.:
Human   643 HKKLKELSVSEC----------------------------YRITDDGIQAFCKSSLILEHLDVSY 679

  Fly   561 CMREASLGDGLFQLLS-NCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGILNITHERVY 624
            |   :.|.|.:.:.|: .|..|..|.::.....|:..:..::|....|..||:.|.:.:|.:.:.
Human   680 C---SQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILE 741

  Fly   625 DILVNCPKLQLLDLSFCDNI 644
            |:.:.|.:|::|.:.:|.||
Human   742 DLQIGCKQLRILKMQYCTNI 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..370	CDD:463757	14/55 (25%)
		leucine-rich repeat	393..422	CDD:275381	8/32 (25%)
		leucine-rich repeat	423..442	CDD:275381	4/18 (22%)
		LRR	<427..>639	CDD:443914	49/213 (23%)
		leucine-rich repeat	449..474	CDD:275381	8/24 (33%)
		leucine-rich repeat	475..499	CDD:275381	7/23 (30%)
		leucine-rich repeat	500..527	CDD:275381	4/26 (15%)
		leucine-rich repeat	528..552	CDD:275381	2/23 (9%)
		leucine-rich repeat	553..580	CDD:275381	9/27 (33%)
		leucine-rich repeat	581..606	CDD:275381	4/24 (17%)
		leucine-rich repeat	607..632	CDD:275381	7/24 (29%)
		leucine-rich repeat	633..652	CDD:275381	5/12 (42%)
FBXL13	NP_001381423.1	DD_FBXL13	8..50	CDD:438546
		Sfi1	<112..>224	CDD:430007
		F-box_FBXL13	245..286	CDD:438896
		leucine-rich repeat	285..312	CDD:275381
		AMN1	312..497	CDD:187754	35/166 (21%)
		leucine-rich repeat	313..336	CDD:275381
		leucine-rich repeat	337..362	CDD:275381
		leucine-rich repeat	363..387	CDD:275381	6/24 (25%)
		leucine-rich repeat	388..406	CDD:275381	4/17 (24%)
		leucine-rich repeat	416..441	CDD:275381	3/25 (12%)
		leucine-rich repeat	442..491	CDD:275381	15/52 (29%)
		leucine-rich repeat	468..490	CDD:275381	6/21 (29%)
		leucine-rich repeat	492..515	CDD:275381	6/23 (26%)
		leucine-rich repeat	518..542	CDD:275381	6/29 (21%)
		AMN1	529..737	CDD:187754	56/248 (23%)
		leucine-rich repeat	543..570	CDD:275381	7/29 (24%)
		leucine-rich repeat	571..596	CDD:275381	5/24 (21%)
		leucine-rich repeat	597..645	CDD:275381	15/49 (31%)
		leucine-rich repeat	646..671	CDD:275381	6/52 (12%)
		leucine-rich repeat	672..697	CDD:275381	9/27 (33%)
		leucine-rich repeat	698..723	CDD:275381	4/24 (17%)
		leucine-rich repeat	724..749	CDD:275381	7/24 (29%)