DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and EEED8.10

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001040757.1	Gene:	EEED8.10 / 173919	WormBaseID:	WBGene00017138	Length:	738	Species:	Caenorhabditis elegans

Alignment Length:	747	Identity:	157/747 - (21%)
Similarity:	252/747 - (33%)	Gaps:	257/747 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLAYGEPAESSETDSPAAEAEPDVLVDFTAMLQRQRQNGDYGGWFGCDSKM-------QTTQSDQ 60
            |||.|:..:..|||            ||.|.:..|..:.|       |.|:       :.|||.
Worm    83 LLADGDAFDGGETD------------DFDASIAFQHTSRD-------DRKIVVSNISAKVTQSQ- 127

  Fly    61 GYYLEQYVLGVLDFSSQYGIDYSISYTAANVIGRPTKFPAYGDYPE----------TFPMRTYGD 115
                      :..|.||||     ..|:..:.....|...:|..|:          ||....:.|
Worm   128 ----------LQSFFSQYG-----KITSCILPREEKKTSVFGTLPKHSRNCGTATITFKKSEHAD 177

  Fly   116 WWQRAPSATREIQPQNLPKLETHDYVVV---YFEE------FVVPTEVAIFE--TFNPGAVVRIW 169
               ||.:|..|       :|:.:|.|:|   |..:      .|:..:|...|  ..:..:..:..
Worm   178 ---RAKNANPE-------ELKFYDQVMVVSAYVSKKRGGKGLVLSDDVGSREDTPLSRASSTQSL 232

  Fly   170 AYGLTKNWTCLWEATESDLSRPPPLDSRR---FAPSLKKTTMLTKTLRID-----FNHSRLNYYT 226
            |.|..:::         :|...|....||   |.|       :.:|:|::     |....:..:.
Worm   233 ASGSEQSF---------NLGNVPDKILRRVISFLP-------IHETIRLERVNKKFMEESIKSWE 281

  Fly   227 EIDAIMLCGRTVTKTQNLLAKQQITQHSRTLVSPPPDAIGSTSGDGSGGSISHKL---RTLKFQP 288
            .::.|.|...||...|    :...|.|.:.:::.....:.|.  |.||  |.|.|   |.||...
Worm   282 LVNKIALARETVFNKQ----RPMRTSHLKAILTRAGAHLRSL--DVSG--IVHLLDDRRALKVIA 338

  Fly   289 NC----------GEDGATKLHEFINNDLSQ------------------FLADNCVDGEAAAPQIC 325
            .|          |.....:..|.:...||.                  ||..||  |.:
Worm   339 TCCPNLVDLDISGTHAQAEALEELGESLSHLEQLSYRGMETTGDKAFYFLLKNC--GHS------ 395

  Fly   326 LTDLPFEILLRILSYLDLKSLFRV-GHVSRTFYDISRHPLLYAEISLKPYWDVASSELLCTLARR 389
                        |.::||::..|: |...:.|.  |:...||.:.|.|.  |..:.|.|||.
Worm   396 ------------LKFVDLRNSKRLHGRSFKLFG--SQLESLYLDGSSKV--DEMAFEDLCTS--- 441

  Fly   390 ATMLRKLDLSWCGGFGNVSPTEFKKFLTQRGDNLTHLRLNSCKFLNASCIENVGIVCDNLIELS- 453
                       |||                   |..||:|.|..:..   ||:.::...:.:||
Worm   442 -----------CGG-------------------LKELRINECYKITD---ENLSMIARRMEDLSI 473

  Fly   454 LRNCA------TEPPLLNFSCLANLKNLERLDLFQTYFETELLLSMLEGNRKLKHLNLAFCG--V 510
            |..|.      |...|::.|.:.|:..| .|| :......|||:|:..|...|..|:||..|  .
Worm   474 LTLCGDGFKSLTSAGLIHISHMRNITEL-ALD-YNALVNDELLISISAGLPLLSSLSLANAGNDS 536

  Fly   511 SVNMDNVAA--HLATYNTQLISLDLWKAHFLSSRGLQSLARLHQLEELDLGWCMREASLGDGLFQ 573
            |:..:.|:|  :|    .:|..||......::|:.|:.|..|.:||.:.|..|   ..|||...:
Worm   537 SITAEGVSAIKNL----KELTQLDASSLAAVNSKVLEQLGSLKKLEIIQLRNC---TYLGDDGVR 594

  Fly   574 LLSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGILNITHERVYDIL---VNCPKLQL 635
            .....|                          |:..:||.|.:.::::.:...:   .:.|||..
Worm   595 AKLRMP--------------------------NIRHVDLSGSILVSNDSIQQFIKAFPSGPKLPP 633

  Fly   636 LDLSFCDNIMDRDFDLLAEWSRQFKVDIKSSR 667
            :.|.......|..           |:.::.||
Worm   634 ITLVVGGTAADAS-----------KLSVRGSR 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	10/46 (22%)
		leucine-rich repeat	393..422	CDD:275381	3/28 (11%)
		leucine-rich repeat	423..442	CDD:275381	6/18 (33%)
		LRR_RI	437..>641	CDD:238064	50/217 (23%)
		leucine-rich repeat	449..474	CDD:275381	8/31 (26%)
		leucine-rich repeat	475..499	CDD:275381	8/23 (35%)
		leucine-rich repeat	500..527	CDD:275381	9/30 (30%)
		leucine-rich repeat	528..552	CDD:275381	7/23 (30%)
		AMN1	552..>660	CDD:187754	17/110 (15%)
		leucine-rich repeat	553..580	CDD:275381	7/26 (27%)
		leucine-rich repeat	581..606	CDD:275381	0/24 (0%)
		leucine-rich repeat	607..632	CDD:275381	3/27 (11%)
		leucine-rich repeat	633..652	CDD:275381	3/18 (17%)
EEED8.10	NP_001040757.1	RRM	<101..273	CDD:223796	41/220 (19%)
		RRM_SF	114..197	CDD:240668	23/108 (21%)
		AMN1	<313..>464	CDD:187754	46/214 (21%)
		leucine-rich repeat	316..337	CDD:275381	10/24 (42%)
		leucine-rich repeat	344..368	CDD:275381	3/23 (13%)
		leucine-rich repeat	369..395	CDD:275381	5/27 (19%)
		AMN1	394..615	CDD:187754	70/313 (22%)
		leucine-rich repeat	396..418	CDD:275381	6/23 (26%)
		leucine-rich repeat	419..444	CDD:275381	10/40 (25%)
		leucine-rich repeat	445..470	CDD:275381	7/27 (26%)
		leucine-rich repeat	471..497	CDD:275381	7/25 (28%)
		leucine-rich repeat	498..520	CDD:275381	7/23 (30%)
		leucine-rich repeat	524..551	CDD:275381	9/30 (30%)
		leucine-rich repeat	552..576	CDD:275381	7/23 (30%)
		leucine-rich repeat	577..601	CDD:275381	8/52 (15%)
		leucine-rich repeat	602..627	CDD:275381	3/24 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910