DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and FBXL14

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_689654.1	Gene:	FBXL14 / 144699	HGNCID:	28624	Length:	418	Species:	Homo sapiens

Alignment Length:	433	Identity:	106/433 - (24%)
Similarity:	164/433 - (37%)	Gaps:	122/433 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 EILLRILSYLDLKSLFRVGHVSRTFYDISRHPLLYAEISLKPYWDVASSELLCTL----ARRATM 392
            |:|..|..|||::...|...|...:.|.:.|..::..:..|.:...|:..|..:|    .||..:
Human    11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGIRRVQI 75

  Fly   393 L----------------RKLDLSWC-----GGFGNVSPTEFKKFLTQRGDNLTHLRLNSCKFLNA 436
            |                ..|:||.|     .|.|:.       |:.:.| :|..|.|:.||.:..
Human    76 LSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHA-------FVQEIG-SLRALNLSLCKQITD 132

  Fly   437 S-------------------C--IENVGIV-----CDNLIELSLRNC-----------------A 458
            |                   |  |.|.|::     ...|..|:||:|                 |
Human   133 SSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSA 197

  Fly   459 TEPPLLNFSCLANLKNLERLDLFQTYFETELLLSML-EGNRKLKHLNLAFCG------------- 509
            .|      .||    .||:|.|......|:|.|..: .|...|:.|||:|||
Human   198 AE------GCL----GLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHM 252

  Fly   510 ---VSVNM---DNVA----AHLATYNTQLISLDLWKAHFLSSRGLQSLARLHQ----LEELDLGW 560
               .|:|:   ||::    .|||..:.:|..||:   .|....|.||||.:.|    |:.|.|
Human   253 GSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDV---SFCDKVGDQSLAYIAQGLDGLKSLSL-- 312

  Fly   561 CMREASLGDGLFQLLSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGILNITHERVYD 625
            |....| .||:.:::.....|:.|.:......|::.|..||.....|..:||.|...|| :|..:
Human   313 CSCHIS-DDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRIT-KRGLE 375

  Fly   626 ILVNCPKLQLLDLSFCDNIMDRDFDLLAEWSRQFKVDIKSSRR 668
            .:...|.|::|:|... .:.|.:.:...::|..|.|..:.|.|
Human   376 RITQLPCLKVLNLGLW-QMTDSEKEARGDFSPLFTVRTRGSSR 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	10/39 (26%)
		leucine-rich repeat	393..422	CDD:275381	9/49 (18%)
		leucine-rich repeat	423..442	CDD:275381	8/39 (21%)
		LRR_RI	437..>641	CDD:238064	70/274 (26%)
		leucine-rich repeat	449..474	CDD:275381	9/41 (22%)
		leucine-rich repeat	475..499	CDD:275381	8/24 (33%)
		leucine-rich repeat	500..527	CDD:275381	14/49 (29%)
		leucine-rich repeat	528..552	CDD:275381	9/23 (39%)
		AMN1	552..>660	CDD:187754	27/111 (24%)
		leucine-rich repeat	553..580	CDD:275381	7/26 (27%)
		leucine-rich repeat	581..606	CDD:275381	6/24 (25%)
		leucine-rich repeat	607..632	CDD:275381	7/24 (29%)
		leucine-rich repeat	633..652	CDD:275381	4/18 (22%)
FBXL14	NP_689654.1	Required for down-regulation of SNAI1	2..48		10/36 (28%)
		F-box-like	5..46	CDD:403981	10/34 (29%)
		AMN1	90..296	CDD:187754	54/226 (24%)
		leucine-rich repeat	92..118	CDD:275381	8/33 (24%)
		leucine-rich repeat	119..142	CDD:275381	6/22 (27%)
		LRR 1	144..163		4/18 (22%)
		leucine-rich repeat	145..170	CDD:275381	4/24 (17%)
		LRR 2	170..191		5/20 (25%)
		leucine-rich repeat	171..203	CDD:275381	9/41 (22%)
		LRR 3	203..225		7/21 (33%)
		leucine-rich repeat	204..229	CDD:275381	8/24 (33%)
		AMN1	228..401	CDD:187754	49/180 (27%)
		LRR 4	229..250		7/20 (35%)
		leucine-rich repeat	230..254	CDD:275381	7/23 (30%)
		LRR 5	254..275		5/20 (25%)
		leucine-rich repeat	255..280	CDD:275381	7/24 (29%)
		leucine-rich repeat	281..306	CDD:275381	10/27 (37%)
		leucine-rich repeat	307..331	CDD:275381	7/26 (27%)
		leucine-rich repeat	332..357	CDD:275381	6/24 (25%)
		leucine-rich repeat	358..382	CDD:275381	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810