DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl4 and fbxl4

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_031761765.1	Gene:	fbxl4 / 100490265	XenbaseID:	XB-GENE-961513	Length:	622	Species:	Xenopus tropicalis

Alignment Length:	613	Identity:	206/613 - (33%)
Similarity:	301/613 - (49%)	Gaps:	60/613 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 QYVLGVLDFSSQYGIDYSISYTAANVIGRPTKFPAYGDYPETFPMRTYGDWWQRAPSATREIQPQ 130
            ||...||||||.||.:.|:|||..|:.|.|..:|:.||:.:|...||||:.|....|.....:..
Frog    55 QYAKEVLDFSSHYGSENSMSYTMWNLAGSPNVYPSSGDFTQTAVFRTYGNLWSNCSSTPAPFKRT 119

  Fly   131 NLPKLETHDYVVVYFEEFVVPTEVAIFETFNPGAVVRIWAYGLTK---------NWTCLWEATES 186
            :: ...:.|||.:.|||.|.||.|.|.||::||:||:|.|.....         .|..:|....:
Frog   120 SV-NFFSQDYVELAFEEPVYPTAVHILETYHPGSVVKILACSANPYSQSAPAEIRWETIWSGEPT 183

  Fly   187 DLSRPPPLDSRRFAPSLKKTTMLTKTLRIDFNHSRLNYYTEIDAIMLCGRTVTKTQNLLAKQQIT 251
            .::.|   .||:|.|.||:.:..|..||::.|.|.|:||||:||:.|.|          .|::..
Frog   184 RVNSP---QSRQFTPCLKEISFPTNLLRLETNSSLLDYYTELDAVELHG----------VKEKPV 235

  Fly   252 QHSRTLVSPPPDAIGSTSGDGSGGSISHKLRTLKFQ-PNCGEDGATKLHEFINNDLSQFLADNCV 315
            ...:|......|.     .|......|.:|.:|..| .|.|      :.|:.||..
Frog   236 LFLKTAAIDMSDL-----DDDYDDKDSCELDSLTNQLSNTG------IREWTNNGY--------- 280

  Fly   316 DGEAAAPQICLTDLPFEILLRILSYLDLKSLFRVGHVSRTFYDISRHPLLYAEISLKPYWDVASS 380
                      ...||:|::..|:|:|.|..|.|:....:..|.....||.|..:||:|||...:.
Frog   281 ----------FDKLPYELIQFIISHLALPDLCRLAQTCKLMYQHCCDPLQYTHLSLQPYWTNVND 335

  Fly   381 ELLCTLARRATMLRKLDLSWCGGFGNVSPTEFKKFLTQRGDNLTHLRLNSCKFLNASCIENVGIV 445
            ..|..|..|.::::.|:|||.|..|.:|.:.|.:.|...|..|..|.|....|||.:|:|.:..:
Frog   336 NSLEYLLPRCSLVQWLNLSWTGNRGLISTSGFSRLLKVCGSELVRLELACGHFLNEACLEVIAEM 400

  Fly   446 CDNLIELSLRNCATEPPLLNFSCLANLKNLERLDLFQTYFETELLLSMLEGNRKLKHLNLAFCGV 510
            |.||.||:|.:|...||.. ||.:..|..|:||.|::|..|...|||:|....:::||||..|.:
Frog   401 CPNLQELNLSSCDKLPPQA-FSHICKLSGLKRLVLYRTKIEQTALLSILNFCPEIQHLNLGSCVL 464

  Fly   511 SVNMDNVAAHLATYNTQLISLDLWKAHFLSSRGLQSLAR-LHQLEELDLGWCMREASLGDGLFQL 574
            ..:.|.||:.|.....:|.|||||:...::.||:..||. ...|||||||||....|.......|
Frog   465 IEDYDLVASVLGAKCKKLRSLDLWRCKNITERGIAELASGCLLLEELDLGWCPTLQSSTGCFVNL 529

  Fly   575 LSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGILNITHERVYDILVNCPKLQLLDLS 639
            .|..|.|:||||:|.|...:.|:..:|...::|:|||::|...::...:..:|..|.:|.|||:|
Frog   530 ASKLPNLRKLFLTANRSVCDSDIEELARNCQHLQQLDILGTRMVSPAALCKLLECCKELFLLDVS 594

  Fly   640 FCDNIMDRDFDLLAEWSRQF-KVDIKSS 666
            ||..|   |..::.|...:| .|.||.|
Frog   595 FCSQI---DSRVVQELVTRFPSVSIKKS 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	14/45 (31%)
		leucine-rich repeat	393..422	CDD:275381	10/28 (36%)
		leucine-rich repeat	423..442	CDD:275381	8/18 (44%)
		LRR_RI	437..>641	CDD:238064	77/204 (38%)
		leucine-rich repeat	449..474	CDD:275381	10/24 (42%)
		leucine-rich repeat	475..499	CDD:275381	10/23 (43%)
		leucine-rich repeat	500..527	CDD:275381	9/26 (35%)
		leucine-rich repeat	528..552	CDD:275381	10/24 (42%)
		AMN1	552..>660	CDD:187754	40/108 (37%)
		leucine-rich repeat	553..580	CDD:275381	12/26 (46%)
		leucine-rich repeat	581..606	CDD:275381	9/24 (38%)
		leucine-rich repeat	607..632	CDD:275381	7/24 (29%)
		leucine-rich repeat	633..652	CDD:275381	9/18 (50%)
fbxl4	XP_031761765.1	F-box-like	281..325	CDD:403981	13/43 (30%)
		leucine-rich repeat	296..318	CDD:275381	5/21 (24%)
		leucine-rich repeat	319..341	CDD:275381	8/21 (38%)
		leucine-rich repeat	348..377	CDD:275381	10/28 (36%)
		leucine-rich repeat	378..403	CDD:275381	9/24 (38%)
		leucine-rich repeat	404..428	CDD:275381	10/24 (42%)
		AMN1	427..606	CDD:187754	67/181 (37%)
		leucine-rich repeat	429..453	CDD:275381	10/23 (43%)
		leucine-rich repeat	454..481	CDD:275381	9/26 (35%)
		leucine-rich repeat	482..507	CDD:275381	10/24 (42%)
		leucine-rich repeat	508..535	CDD:275381	12/26 (46%)
		leucine-rich repeat	536..561	CDD:275381	9/24 (38%)
		leucine-rich repeat	562..587	CDD:275381	7/24 (29%)
		leucine-rich repeat	588..613	CDD:275381	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	167	1.000	Domainoid score	I3808
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8128
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2764
OMA	1	1.010	-	-		QHG50183
OrthoDB	1	1.010	-	-		D298796at33208
OrthoFinder	1	1.000	-	-		FOG0003673
OrthoInspector	1	1.000	-	-		oto105004
Panther	1	1.100	-	-	LDO	PTHR13318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7198
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080