DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and si:ch73-173p19.1

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_002660968.3	Gene:	si:ch73-173p19.1 / 100332407	ZFINID:	ZDB-GENE-130530-952	Length:	918	Species:	Danio rerio

Alignment Length:	396	Identity:	108/396 - (27%)
Similarity:	150/396 - (37%)	Gaps:	117/396 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 CLTDLPFEILLRILSYLDLKSLFRVGHVSRTFYDISRHPLLYAEISLKPYWDVASSELLCTLARR 389
            |||.   |:...:||::..:.|.|    .||.......||....::..||   .::|||..| |.
Zfish   488 CLTP---ELAELLLSHMARERLLR----PRTLELFFGCPLQKFVLNCYPY---TTNELLRQL-RA 541

  Fly   390 ATMLRKLDLSWCGGFGNVSPTEFKKFLTQRG-------DNLTHLRLNSCKFLNASCIENV----- 442
            .|.|:.|      .|.| ||     .:|..|       ..|.||.|:||..|..||::::
Zfish   542 FTCLKHL------SFLN-SP-----LITDAGLSVLSNLSKLQHLNLSSCSKLTDSCLQHITGLRS 594

  Fly   443 --------------GIV------CDNLIELSLRNCA-TEPPL--------------------LNF 466
                          |::      ...|.:|||...| ||..|                    .:.
Zfish   595 LTFLALDQTKVSDAGLLLYLQSGSSALCQLSLNQTAITESTLRVLPASVPQLRMLSIKHTKVSDV 659

  Fly   467 SCLANLKNLERLDLFQTYFETELLLSMLEGNRKLKHLNLAFCGVSVNMDNVAAHLATYNTQLISL 531
            |.||.||||:.|.|..|..: |..|..|..:..|..|:||  |:.|...|....:.. ..:|..|
Zfish   660 SALAELKNLQTLHLDGTGVQ-ENSLQCLASHPSLSALSLA--GIPVADGNHTLEIIA-GLRLTQL 720

  Fly   532 DLWKAHFLSSRGLQSLARLHQLEELDLGWCMREASLGDGLFQLLSNCPKLKKLFLSAVR------ 590
            .|...|.::..||..|:|...|.||||   .....|.|.....||:..:||||.||..:
Zfish   721 TLPGRHSVTDSGLSFLSRQTLLLELDL---TDYTQLTDHGITQLSSMTRLKKLSLSNTQVSDSGL 782

  Fly   591 -----------------GTTERDLMHIAALGKNLEQLDLMGILNITHERVYDI-----LVNCPKL 633
                             ..|.|.   :|||..:|..|.:||:.:   .:|.|.     ||:||:|
Zfish   783 QGLIRLKELQELCLDRTAVTSRG---VAALITHLPHLQVMGLAS---TQVGDTVIRRGLVHCPQL 841

  Fly   634 QLLDLS 639
            ..|:||
Zfish   842 LKLNLS 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	11/45 (24%)
		leucine-rich repeat	393..422	CDD:275381	8/35 (23%)
		leucine-rich repeat	423..442	CDD:275381	9/18 (50%)
		LRR_RI	437..>641	CDD:238064	73/277 (26%)
		leucine-rich repeat	449..474	CDD:275381	12/45 (27%)
		leucine-rich repeat	475..499	CDD:275381	7/23 (30%)
		leucine-rich repeat	500..527	CDD:275381	7/26 (27%)
		leucine-rich repeat	528..552	CDD:275381	8/23 (35%)
		AMN1	552..>660	CDD:187754	34/116 (29%)
		leucine-rich repeat	553..580	CDD:275381	9/26 (35%)
		leucine-rich repeat	581..606	CDD:275381	11/47 (23%)
		leucine-rich repeat	607..632	CDD:275381	9/29 (31%)
		leucine-rich repeat	633..652	CDD:275381	4/7 (57%)
si:ch73-173p19.1	XP_002660968.3	UBA_like_SF	6..43	CDD:304366
		Nop25	116..>169	CDD:286843
		UBQ	187..260	CDD:294102
		AMN1	523..701	CDD:187754	52/196 (27%)
		LRR	<524..710	CDD:227223	54/204 (26%)
		leucine-rich repeat	545..569	CDD:275381	8/35 (23%)
		leucine-rich repeat	570..594	CDD:275381	9/23 (39%)
		leucine-rich repeat	595..620	CDD:275381	1/24 (4%)
		leucine-rich repeat	621..645	CDD:275381	8/23 (35%)
		leucine-rich repeat	646..691	CDD:275381	13/45 (29%)
		leucine-rich repeat	692..766	CDD:275381	24/79 (30%)
		leucine-rich repeat	717..742	CDD:275381	8/24 (33%)
		AMN1	750..>888	CDD:187754	29/104 (28%)
		leucine-rich repeat	767..790	CDD:275381	6/22 (27%)
		leucine-rich repeat	791..815	CDD:275381	6/26 (23%)
		leucine-rich repeat	816..840	CDD:275381	8/26 (31%)
		leucine-rich repeat	841..863	CDD:275381	4/7 (57%)
		leucine-rich repeat	864..888	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900