DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl4 and si:dkey-192l18.9

DIOPT Version :9

Sequence 1:	NP_572951.1	Gene:	Fbxl4 / 32378	FlyBaseID:	FBgn0030555	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_001344855.1	Gene:	si:dkey-192l18.9 / 100005961	ZFINID:	ZDB-GENE-120709-25	Length:	476	Species:	Danio rerio

Alignment Length:	469	Identity:	112/469 - (23%)
Similarity:	170/469 - (36%)	Gaps:	122/469 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 QNLLAKQQITQHSRT-----LVSP-PPDAI--GSTSGDGSGGSISHKLRTLKFQPNCGEDGATKL 298
            :|....:...|..||     :::| ||..:  |..|..|...::.|       .|......:||
Zfish    36 KNAATSEDSDQSMRTPSPALILNPNPPQTVPNGRESSLGETVALIH-------PPPATRSKSTK- 92

  Fly   299 HEFINNDLSQFLADNCVDGEAAAPQICLTD-LPFEILLRILSYLDLKSLFRVGHVSRTFYDISRH 362
                                  .|...|.| ||..:||.|||||....|.....|.|.:|::|..
Zfish    93 ----------------------PPHTALIDILPDPVLLHILSYLSTPHLCLCARVCRRWYNLSWD 135

  Fly   363 PLLYAEISLKPYWDVASSELLCTLARRATMLRKLDLSWCGGFGNVSPTEFKKFLTQRGDNLTHLR 427
            |.|::.|.|       :.|||  .|.||  |:.|....|....||..|            |..:.
Zfish   136 PRLWSTIRL-------NGELL--NADRA--LKVLTHRLCQDTPNVCLT------------LETVV 177

  Fly   428 LNSCKFLNASCIENVGIVCDNLIELSLRNCATEPPLLNFSCLANLKNLERLDL--------FQTY 484
            .:.|:.|:...:..:...|..|..|.:..|........|..::...|||.||:        ....
Zfish   178 ASGCRRLSDRGLRVIARCCPELRCLEVAGCYNVSNDAVFDVVSKCPNLEHLDVSGCPKVTCISLT 242

  Fly   485 FETELLLSMLEGNR-KLKHLNLAFCGVSV---NMDNVAAH----------------------LAT 523
            .|..:..:.|.|.: .|::||:..| ||:   .:..:|.|                      ||.
Zfish   243 EEGSVQHTPLHGQQIGLRYLNMTDC-VSLEDKGLKTIAIHCPRLTHLYLRRCIRITDESLRQLAL 306

  Fly   524 YNTQLISLDLWKAHFLSSRGLQSLARLH-QLEELDLGWCMREASLG------------------- 568
            :.|.|..|.|...|.:...||:.:|||. :|..|.:..|||...:|
Zfish   307 HCTALRELSLSDCHLVGDFGLREVARLEGRLRYLSVAHCMRITDVGLRYVARYCPRLRYLNARGC 371

  Fly   569 -----DGLFQLLSNCPKLKKLFLSAVRGTTERDLMHIAALGKNLEQLDLMGILNITHERVYDILV 628
                 .||..|..|||:|:.:.:......::..|..:|...|.|.:|.|.|..::|...:..:..
Zfish   372 EGLTDQGLSYLARNCPRLRSIDVGRCPLVSDAGLEVLAHCCKMLRRLSLRGCESLTGRGLMALAE 436

  Fly   629 NCPKLQLLDLSFCD 642
            .||:||||::..||
Zfish   437 GCPELQLLNVQECD 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl4	NP_572951.1	F-box-like	326..372	CDD:289689	19/46 (41%)
		leucine-rich repeat	393..422	CDD:275381	6/28 (21%)
		leucine-rich repeat	423..442	CDD:275381	3/18 (17%)
		LRR_RI	437..>641	CDD:238064	60/262 (23%)
		leucine-rich repeat	449..474	CDD:275381	4/24 (17%)
		leucine-rich repeat	475..499	CDD:275381	7/32 (22%)
		leucine-rich repeat	500..527	CDD:275381	10/51 (20%)
		leucine-rich repeat	528..552	CDD:275381	9/24 (38%)
		AMN1	552..>660	CDD:187754	29/115 (25%)
		leucine-rich repeat	553..580	CDD:275381	11/50 (22%)
		leucine-rich repeat	581..606	CDD:275381	3/24 (13%)
		leucine-rich repeat	607..632	CDD:275381	6/24 (25%)
		leucine-rich repeat	633..652	CDD:275381	6/10 (60%)
si:dkey-192l18.9	XP_001344855.1	F-box-like	99..145	CDD:289689	19/52 (37%)
		leucine-rich repeat	114..138	CDD:275381	7/23 (30%)
		leucine-rich repeat	139..172	CDD:275381	13/43 (30%)
		leucine-rich repeat	173..198	CDD:275381	4/24 (17%)
		leucine-rich repeat	199..220	CDD:275381	4/20 (20%)
		LRR_CC	222..246	CDD:197685	6/23 (26%)
		leucine-rich repeat	225..258	CDD:275381	7/32 (22%)
		leucine-rich repeat	259..284	CDD:275381	8/25 (32%)
		AMN1	280..465	CDD:187754	42/171 (25%)
		leucine-rich repeat	285..310	CDD:275381	2/24 (8%)
		leucine-rich repeat	311..336	CDD:275381	9/24 (38%)
		leucine-rich repeat	337..362	CDD:275381	6/24 (25%)
		leucine-rich repeat	363..388	CDD:275381	5/24 (21%)
		leucine-rich repeat	389..414	CDD:275381	3/24 (13%)
		leucine-rich repeat	415..440	CDD:275381	6/24 (25%)
		leucine-rich repeat	441..465	CDD:275381	6/10 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810