DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1434 and Dus2

DIOPT Version :9

Sequence 1:	NP_001285237.1	Gene:	CG1434 / 32377	FlyBaseID:	FBgn0030554	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_079794.1	Gene:	Dus2 / 66369	MGIID:	1913619	Length:	493	Species:	Mus musculus

Alignment Length:	457	Identity:	226/457 - (49%)
Similarity:	301/457 - (65%)	Gaps:	21/457 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LDYRNKLILAPMVRVGTLPMRLLALEMGADIVYTEELVDIKLIKSIRRPNPALGTVDFVDPSDGT 84
            |.|.|||||||||||||||||||||:.||||||.|||:|:|:::..|..|..|.|||||.|.| .
Mouse     8 LCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEELIDLKMLQCKRVVNEVLSTVDFVAPDD-R 71

  Fly    85 IVFRTCAQETSRLVLQMGTSDAGRALAVGKLLQRDISGLDINMGCPKEFSIKGGMGAALLADPDK 149
            :|||||.:|.||:|.|||||||.|||||.:|::.|::|:|:|||||||:|.|||||||||:||||
Mouse    72 VVFRTCEREQSRVVFQMGTSDAERALAVARLVENDVAGIDVNMGCPKEYSTKGGMGAALLSDPDK 136

  Fly   150 AAHILRTLCSGLDIPVTCKIRILPDVEGTIDLVQKLAATGIAAIGIHARTRDERPQHPAHPEVLR 214
            ...||.||..|...||||||||||.:|.|::||:::..|||:||.:|.|.||||||||...||:|
Mouse   137 IEKILSTLVKGTHRPVTCKIRILPSLEDTLNLVKRIERTGISAIAVHGRNRDERPQHPVSCEVIR 201

  Fly   215 AVAQAVDIPIIANGGS-KNMHCYDDLRKFQMECGADSVMVARAAQINVSIFRPEGLLPMDELIEK 278
            |:|:.:.||:|||||| .::..:.|:..|:....|.||||||||..|.|||..:||.|::|:::|
Mouse   202 AIAETLSIPVIANGGSHDHIQQHVDIEDFRQATAASSVMVARAAMWNPSIFLKDGLRPLEEVMQK 266

  Fly   279 YLRLCVDYDNAPHNAKYCVQSILRELQETPRGKRFLQCQTLQQICEIWELGDYCRRKQRELKTMG 343
            |:|..|.|||...|.|||:..:|||..|:|:|:.....|:.|:|||.:.||.:.....|||
Mouse   267 YIRYAVQYDNHYTNTKYCLCQMLREQLESPQGRLLHAAQSSQEICEAFGLGAFYEETIREL---- 327

  Fly   344 NSGRAEV--EPPEALAKRQKLEDAAIAITDEYDGIICRHMPFLRSTYPSDNHLPKTQLYVHAVKT 406
            ::.||::  :.|||      :|:.|    ::..|||...:.|.|..|| ....||..|.....:.
Mouse   328 DARRADLLAKTPEA------VEEPA----EDTSGIIKMAIRFDRRAYP-PQITPKMCLLEWCRRE 381

  Fly   407 GKSPPAYETQQ--CDKLFRSICTYDGQRFSSSFWEKNKKQAEQGAALVALLHLGQLEAEVLRDNG 469
            ....|.|||.|  .|::|.|:.|...|::.|:.|:|:||.|||.||:|.|...|..|..:..::.
Mouse   382 KLPQPVYETVQRTIDRMFCSVVTVAEQKYQSTLWDKSKKLAEQTAAIVCLRSQGLPEGRLGEESP 446

  Fly   470 SL 471
            ||
Mouse   447 SL 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1434	NP_001285237.1	DusA	14..287	CDD:223120	160/267 (60%)
		DUS_like_FMN	25..266	CDD:239200	149/241 (62%)
		Rnc	<317..461	CDD:223644	50/147 (34%)
		DSRM	395..457	CDD:238007	25/63 (40%)
Dus2	NP_079794.1	Catalytic domain. /evidence=ECO:0000250\|UniProtKB:Q9NX74	1..333		184/329 (56%)
		DUS_like_FMN	13..252	CDD:239200	147/239 (62%)
		Interaction with tRNA. /evidence=ECO:0000250\|UniProtKB:Q9NX74	367..371		0/3 (0%)
		DSRM_DUS2L	369..436	CDD:380700	25/66 (38%)
		Interaction with tRNA. /evidence=ECO:0000250\|UniProtKB:Q9NX74	420..424		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..472		3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850158
Domainoid	1	1.000	288	1.000	Domainoid score	I1569
eggNOG	1	0.900	-	-		E1_COG0042
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6838
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1937
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004414
OrthoInspector	1	1.000	-	-		oto95003
orthoMCL	1	0.900	-	-		OOG6_102617
Panther	1	1.100	-	-	LDO	PTHR45936
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2098
SonicParanoid	1	1.000	-	-		X3701
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.780