DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1434 and DUS3L

DIOPT Version :9

Sequence 1:	NP_001285237.1	Gene:	CG1434 / 32377	FlyBaseID:	FBgn0030554	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_064560.2	Gene:	DUS3L / 56931	HGNCID:	26920	Length:	650	Species:	Homo sapiens

Alignment Length:	372	Identity:	94/372 - (25%)
Similarity:	155/372 - (41%)	Gaps:	71/372 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RQRLDYRNKLILAPMVRVGTLPMRLLALEMGADIVYTEELVDIKLIKSIRRPNPALGTVDFVDPS 81
            ::|||.|.||.|||:...|.||.|.:....|||:...|..|...|::.              ..|
Human   298 KKRLDIRGKLYLAPLTTCGNLPFRRICKRFGADVTCGEMAVCTNLLQG--------------QMS 348

  Fly    82 DGTIVFRTCAQETSRLVLQMGTSDAGRALAVGKLLQR--DISGLDINMGCPKEFSIKGGMGAALL 144
            :..::.|...::...:.|:....|.....|  :||.|  ::..:|||:|||.:...|.|.|.||:
Human   349 EWALLKRHQCEDIFGVQLEGAFPDTMTKCA--ELLSRTVEVDFVDINVGCPIDLVYKKGGGCALM 411

  Fly   145 ADPDKAAHILRTLCSGLDIPVTCKIRILPDVEGTIDLVQKLAAT----GIAAIGIHARTRDERPQ 205
            ....|...|:|.:...||:|:|.|||  ..|:..::|..:|...    |:|.:.:|.|:|::|..
Human   412 NRSTKFQQIVRGMNQVLDVPLTVKIR--TGVQERVNLAHRLLPELRDWGVALVTLHGRSREQRYT 474

  Fly   206 HPAHPEVLRAVAQAVD-IPIIANGGSKNMHCYDDLRKFQMECGADSVMVARAAQINVSIFRPEGL 269
            ..|..:.:....||.. :|:..||   ::..::|..: .|:.|...:|:||.|.:...:|
Human   475 KLADWQYIEECVQAASPMPLFGNG---DILSFEDANR-AMQTGVTGIMIARGALLKPWLF----- 530

  Fly   270 LPMDELIE---------KYLRLCVDYDNAPHNAKYCVQSILRELQETPRGKRFLQCQTLQQICEI 325
               .|:.|         :.|.:..|:.|      |.::....:.|...:.:||| .:.|..:|..
Human   531 ---TEIKEQRHWDISSSERLDILRDFTN------YGLEHWGSDTQGVEKTRRFL-LEWLSFLCRY 585

  Fly   326 WELGDYCRRKQRELKTMGNSGRAEVEPP--------EALAKRQKLED 364
            ..:|...|..|          |....||        |.|...||..|
Human   586 VPVGLLERLPQ----------RINERPPYYLGRDYLETLMASQKAAD 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1434	NP_001285237.1	DusA	14..287	CDD:223120	75/285 (26%)
		DUS_like_FMN	25..266	CDD:239200	67/247 (27%)
		Rnc	<317..461	CDD:223644	13/56 (23%)
		DSRM	395..457	CDD:238007
DUS3L	NP_064560.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..120
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..284
		DusA	297..576	CDD:223120	81/314 (26%)
		DUS_like_FMN	306..538	CDD:239200	69/261 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0042
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810