DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11674 and DKK1

DIOPT Version :9

Sequence 1:	NP_572948.1	Gene:	CG11674 / 32374	FlyBaseID:	FBgn0030551	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_036374.1	Gene:	DKK1 / 22943	HGNCID:	2891	Length:	266	Species:	Homo sapiens

Alignment Length:	198	Identity:	35/198 - (17%)
Similarity:	59/198 - (29%)	Gaps:	70/198 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 CLEDKDCGS------------CGASICLTKTKRCGCSKNFVHNHNMTKCIKGSAYGDTCEHSSPC 213
            |.||::||:            .|..|||...||            ..:|::         |:..|
Human    85 CAEDEECGTDEYCASPTRGGDAGVQICLACRKR------------RKRCMR---------HAMCC 128

  Fly   214 KLNLGADGRCLDHLCVCR-STHYPKRVANEVAKDENDDLDAVNNLERITCAPIVPF------GAL 271
            ..|.     |.:.:||.. ..|:...:...:.:...:|...::...|.|......:      |::
Human   129 PGNY-----CKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYHTKGQEGSV 188

  Fly   272 CRNDSECRMQPMDQENATASIGHPMV----------------------CNWGE---CSCSKTHRL 311
            |...|:|........:..:.|..|::                      |..||   |...|.|..
Human   189 CLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCGEGLSCRIQKDHHQ 253

  Fly   312 EDN 314
            ..|
Human   254 ASN 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11674	NP_572948.1	EB	96..153	CDD:279949
DKK1	NP_036374.1	Dickkopf_N	85..139	CDD:309719	16/79 (20%)
		DKK-type Cys-1	85..138		16/78 (21%)
		DKK-type Cys-2	189..263		12/68 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900