DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11674 and MEGF6

DIOPT Version :9

Sequence 1:	NP_572948.1	Gene:	CG11674 / 32374	FlyBaseID:	FBgn0030551	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	XP_011539187.1	Gene:	MEGF6 / 1953	HGNCID:	3232	Length:	1603	Species:	Homo sapiens

Alignment Length:	339	Identity:	78/339 - (23%)
Similarity:	98/339 - (28%)	Gaps:	116/339 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 CSSDAQCAQFERGRC--VDMACICTARGSGER-----------------------VPCTPLEERL 68
            ||.:.||.|.....|  .|.:|.|.|...|||                       |.|.
Human   712 CSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACD------ 770

  Fly    69 KLTNIIGGACP-----------CPM-------------PNAICHTRWQQCHCSEGHVSSDDRRRC 109
            .::...|..||           ||:             ..|.||....||.|..|....|....|
Human   771 SVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADC 835

  Fly   110 LPAVVPVG----GSCEFQQQCQRADRFSSCIGNQCLCLNQFEFHEGRCLSVLQS-----SCLEDK 165
                 |.|    |..|....||.|.|.....| .||||..|.  ..||..|..:     ||....
Human   836 -----PEGRWGLGCQEICPACQHAARCDPETG-ACLCLPGFV--GSRCQDVCPAGWYGPSCQTRC 892

  Fly   166 DCGSCGASICLTKTKRCGCSKNFVHNHNMTKCIKGSAYGDTCEHSSPCKLNLGADGRC--LDHLC 228
            .|.:.|.  |...|..|.|:..:........|..|. :|..|.|  ||..:.| .|.|  :..||
Human   893 SCANDGH--CHPATGHCSCAPGWTGFSCQRACDTGH-WGPDCSH--PCNCSAG-HGSCDAISGLC 951

  Fly   229 VCRSTHYPKRVANEVAKDENDDLDAVNNLERITCAPIVPFGALCRNDSECRMQPMDQENATASIG 293
            :|.:.:...|...:                    .|...||..|....:|:
Human   952 LCEAGYVGPRCEQQ--------------------CPQGHFGPGCEQRCQCQ-------------- 982

  Fly   294 HPMVCNW--GECSC 305
            |...|:.  |.|:|
Human   983 HGAACDHVSGACTC 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11674	NP_572948.1	EB	96..153	CDD:279949	18/60 (30%)
MEGF6	XP_011539187.1	EMI	108..176	CDD:284877
		vWFA	<215..261	CDD:294047
		FXa_inhibition	268..304	CDD:291342
		vWFA	<342..384	CDD:294047
		FXa_inhibition	397..432	CDD:291342
		vWFA	<432..469	CDD:294047
		vWFA	<472..511	CDD:294047
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900