DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11674 and Stab1

DIOPT Version :9

Sequence 1:	NP_572948.1	Gene:	CG11674 / 32374	FlyBaseID:	FBgn0030551	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_619613.2	Gene:	Stab1 / 192187	MGIID:	2178742	Length:	2571	Species:	Mus musculus

Alignment Length:	387	Identity:	91/387 - (23%)
Similarity:	128/387 - (33%)	Gaps:	140/387 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GFLATGRAEDLLELSCSSDA------QCAQFERGRCVD-----MACICTARGSGERVP------- 60
            ||..|.     .|| |:..|      .|...:.|||.:     .:|.|....:|.|..
Mouse  2000 GFAGTA-----CEL-CAPGAFGPQCQACRCTQHGRCDEGLGGSGSCFCDEGWTGARCEVQLELQP 2058

  Fly    61 -CTPLEERLKLTNIIGGACPCPMPNAICHTRWQQCHCSEGHVSSDDRRRCLPA-VVPVG-GSCEF 122
             |||               || .|.|:|.. ...|.||.|:  ..|.|.|..| :...| |.|..
Mouse  2059 VCTP---------------PC-APQAVCRL-GNSCECSLGY--EGDGRVCTVADLCQKGHGGCSK 2104

  Fly   123 QQQCQRADRFSSCIGN--QCLCLNQFEFHEG-------RCLSVLQSSCLEDKDCGSCGASICLTK 178
            ...|       |.:|.  .|.||..:| .:|       .||...:..|.|..||.:.|.:
Mouse  2105 HANC-------SQVGTVVTCTCLPDYE-GDGWSCRARDPCLDGHRGGCSEHADCLNTGPN----- 2156

  Fly   179 TKRCGCSKNFVHN---------HNMTKCIKGSAYGDTCEHSSPCKLNLGADGRCLD--------- 225
            |:||.|...:|.:         ..:.:|:.|         ||||.    .|..|.|
Mouse  2157 TRRCECHVGYVGDGLQCLEELEPPVDRCLGG---------SSPCH----TDALCTDLHFQEKQAG 2208

  Fly   226 --HLCVCRSTHYPKRVANEVAKDENDDLDAV-NNLERITCAPIVPF-----GALCRNDSECRMQP 282
              |:   ::|..|..:....||:..:...|| .:|.:::.|..:.|     |.|
Mouse  2209 VFHI---QATSGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHVCFVGWL----------- 2259

  Fly   283 MDQENATASIGHPMVCNWGECSCSKT-----------HRLEDNKCVFVENSATNYQLR-GFV 332
                 |..|..||:|....:|..::.           ..|.|..|..|::.|.  |.| |||
Mouse  2260 -----ANGSAAHPVVTPAADCGNNRVGVVSLGVRKNLSELWDAYCYRVQDVAC--QCRAGFV 2314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11674	NP_572948.1	EB	96..153	CDD:279949	18/67 (27%)
Stab1	NP_619613.2	Fasciclin	520..644	CDD:280607
		EGF_3	915..946	CDD:289699
		EGF_3	952..988	CDD:289699
		Fasciclin	1000..1121	CDD:280607
		EGF_3	1460..1496	CDD:289699
		EGF_3	1502..1539	CDD:289699
		EGF_3	1545..1582	CDD:289699
		Fasciclin	1607..1711	CDD:280607
		Fasciclin	1737..1867	CDD:280607
		EGF_Lam	<1992..2021	CDD:214543	7/26 (27%)
		EGF_3	2095..2130	CDD:289699	11/42 (26%)
		EGF_3	2136..2173	CDD:289699	12/41 (29%)
		Link_Domain	2208..2300	CDD:295393	20/110 (18%)
		FAS1	2367..2463	CDD:214719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900