DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11674 and si:ch211-221n20.8

DIOPT Version :9

Sequence 1:	NP_572948.1	Gene:	CG11674 / 32374	FlyBaseID:	FBgn0030551	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	XP_021324390.1	Gene:	si:ch211-221n20.8 / 100034409	ZFINID:	ZDB-GENE-041014-220	Length:	737	Species:	Danio rerio

Alignment Length:	393	Identity:	88/393 - (22%)
Similarity:	128/393 - (32%)	Gaps:	125/393 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AGFLATGRAEDLLEL-SC-SSDAQCAQFERGRCVDMA----CICTARGSGERV---PCTPLEERL 68
            ||:..|....:..:: .| ||:.:|.|    .|.:.|    |.| .||....:   .|..::| .
Zfish   298 AGYTITADLHNCTDVDECVSSNDRCEQ----TCTNTAGSFLCSC-RRGFQLHIDGHSCVDIDE-C 356

  Fly    69 KL---------TNIIGG-ACPCPMP------NAIC-------------------------HTRWQ 92
            ||         ||..|| .|.||.|      |..|                         |
Zfish   357 KLQNGGCSHECTNTEGGHQCHCPFPLLLDLRNTTCVNVTSCALRNGGCDHICSLGAESRIH---- 417

  Fly    93 QCHCSEGHVSSDDRRRCLPA--VVPVGGSCEFQQQCQRADRFSSCIGNQCLCLNQFEF---HEGR 152
             |.|..|...|.|:|.|:..  .|.|.|.||  |.|     .:...|..|.|...||.   |..:
Zfish   418 -CSCRAGWELSADQRTCIDVDECVSVNGGCE--QVC-----VNHAGGFNCSCRAGFELRKDHPTK 474

  Fly   153 CLSVLQSSCLEDKDCGSCGASICLTKTKRCGCSKNFVHNHNMTKCIKGSAYGDTCE--------- 208
            |..:...:|.....|.:.....|.......|||         ..|....|:|.:|.
Zfish   475 CQPLCDPACQNSGVCVAPNTCDCPAGYPGAGCS---------AMCSPPCAHGGSCMRWNVCLCSP 530

  Fly   209 -------HSSPCKLNLGADGRCL-DHLCVCRSTHY-PKRVANE-----------VAKDENDDLD- 252
                   |::.|:|.....|||: .:.|.|.|.:. |:.:..:           ||.:....||
Zfish   531 GWTGEGCHTAVCELPCANGGRCIAPNTCQCPSDYSGPQCLTPQCSPPCVNGGRCVAINTCSCLDG 595

  Fly   253 ---AVNNLERITCAPIVPFGALCRNDSECR-MQPMDQENATASIGHPMV--CNWG-------ECS 304
               |...:|.:.|.|....|.:|...:.|: ::....::...::..|.|  |..|       .|.
Zfish   596 WRGARCQIEPVRCVPACNNGGVCVGLNRCQCVEGYTGKHCETALVTPCVPPCQHGAVCAPLNSCV 660

  Fly   305 CSK 307
            |.|
Zfish   661 CPK 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11674	NP_572948.1	EB	96..153	CDD:279949	19/61 (31%)
si:ch211-221n20.8	XP_021324390.1	EGF_CA	57..>90	CDD:214542
		cEGF	126..149	CDD:315355
		EGF_CA	146..184	CDD:214542
		EGF_CA	188..227	CDD:311536
		EGF_3	233..268	CDD:315598
		vWFA	<268..305	CDD:320736	3/6 (50%)
		vWFA	<309..347	CDD:320736	11/42 (26%)
		cEGF	332..355	CDD:315355	5/23 (22%)
		FXa_inhibition	356..391	CDD:317114	11/34 (32%)
		FXa_inhibition	397..433	CDD:317114	7/40 (18%)
		vWFA	<433..470	CDD:320736	13/43 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561378at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010