Protein Alignment Prp16 and DHX38

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: NP_054722.2
• Gene: DHX38 / 9785
• HGNCID: 17211
• Length: 1227
• Species: Homo sapiens
• Alignment Length: 1268
• Identity: 772/1268 - (60%)
• Similarity: 953/1268 - (75%)
• Gaps: 87/1268 - (6%)

  Fly     1 MSD-DDESGVHRLEGTAGQETRGGLVIRKPKDAGAGGGGGFK--VPQGSMLGLDKLAAKRRAEKE 62
            |.| .:::.:||||||......|||:. |.|.| |.....||  .|:.|:||||.||:.:|.|:|
Human     1 MGDTSEDASIHRLEGTDLDCQVGGLIC-KSKSA-ASEQHVFKAPAPRPSLLGLDLLASLKRRERE 63

  Fly    63 --------RSERLISFKDSEFDDTGGGSSTPQANASGASSEFAFKKPDTKSFEKLRGQLREHKDD 119
                    :..::.|:||.|      .|...|.:|.....:.|     .::..|.| ..|..:.:
Human    64 EKDDGEDKKKSKVSSYKDWE------ESKDDQKDAEEEGGDQA-----GQNIRKDR-HYRSARVE 116

  Fly   120 TPSHTGGVSEKARERLREHIQRDRKRGPVSSTAAEGRDRDRDWDRDRRRDRDRDRDRDRDRRQHR 184
            ||||.|||||:..||.|:..:..|:.|..:|:..|     :||.:::.||||.||.||||
Human   117 TPSHPGGVSEEFWERSRQRERERREHGVYASSKEE-----KDWKKEKSRDRDYDRKRDRD----- 171

  Fly   185 ERERDRHRS-WDRDRGRDRDRDRSMSERSVHTPREPGTPGGSSGGISNSSWDDEDGEFG-QRKSD 247
            ||:|.||.| .:||.|.:|...|:..|...|.|::..||       |.|:|::||..:| .|:|.
Human   172 ERDRSRHSSRSERDGGSERSSRRNEPESPRHRPKDAATP-------SRSTWEEEDSGYGSSRRSQ 229

  Fly   248 WDMPTP--------RRH--GNKSGDWSVRSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRSGAT 302
            |:.|:|        |.|  ..:..|.|||...|       |||..|||:::||:||..|:..|:|
Human   230 WESPSPTPSYRDSERSHRLSTRDRDRSVRGKYS-------DDTPLPTPSYKYNEWADDRRHLGST 287

  Fly   303 P----------WGEDPESLDL------WEEEQRRLDREWYNIDEGYDDENNPFGGPNSEYFRKRE 351
            |          .||:..|.|.      ||::||:.||:||.:|||||:.:||....:.:|.|:||
Human   288 PRLSRGRGRREEGEEGISFDTEEERQQWEDDQRQADRDWYMMDEGYDEFHNPLAYSSEDYVRRRE 352

  Fly   352 EQLEQKRTKRISAQQRQNNRDNELWERNRMLTSGVVTLISVNDDFDEEALERVHLLVHHIIPPFL 416
            :.|.:::.||||||:||.|.|||.||.|||||||||..:.|::||:|:...:|||:||:::||||
Human   353 QHLHKQKQKRISAQRRQINEDNERWETNRMLTSGVVHRLEVDEDFEEDNAAKVHLMVHNLVPPFL 417

  Fly   417 DGRIVFTKQPEPVVPVKDPTSDMALLARKGSALVRNYREQKERRKAQKKHWELSGTKLGNIMGVQ 481
            |||||||||||||:||||.|||:|::|||||..||.:||||||:|||.|||||:|||||:||||:
Human   418 DGRIVFTKQPEPVIPVKDATSDLAIIARKGSQTVRKHREQKERKKAQHKHWELAGTKLGDIMGVK 482

  Fly   482 RPQDEDDMRFDKEKDKADYRKDQKFADHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQELLNV 546
            :.::.|  :...|..|.|||.:|||||||: :.:...|:|::||:|.|||::||:||.:||||.:
Human   483 KEEEPD--KAVTEDGKVDYRTEQKFADHMK-RKSEASSEFAKKKSILEQRQYLPIFAVQQELLTI 544

  Fly   547 IRENSVIIIVGETGSGKTTQLTQYLHEDGYSKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDV 611
            ||:||::|:|||||||||||||||||||||:..|||||||||||||||||||||:||...|||:|
Human   545 IRDNSIVIVVGETGSGKTTQLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEV 609

  Fly   612 GYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVAR 676
            ||||||||||||.|:|||||||||||||||:.:||.||||||||||||||:||||||||||:|||
Human   610 GYAIRFEDCTSENTLIKYMTDGILLRESLREADLDHYSAIIMDEAHERSLNTDVLFGLLREVVAR 674

  Fly   677 RHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPN 741
            |.||||||||||||:.|||.||||||.|.|||||||||::|||...|||||:||||:|||||:..
Human   675 RSDLKLIVTSATMDAEKFAAFFGNVPIFHIPGRTFPVDILFSKTPQEDYVEAAVKQSLQVHLSGA 739

  Fly   742 EGDMLIFMPGQEDIEVTCEVLEERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVA 806
            .||:|||||||||||||.:.:.|.|.|::|||||::||||||||||||||||||:.||:|||:||
Human   740 PGDILIFMPGQEDIEVTSDQIVEHLEELENAPALAVLPIYSQLPSDLQAKIFQKAPDGVRKCIVA 804

  Fly   807 TNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLY 871
            |||||||||||||::|||||||||||:|||||||||||||||||||||||||||||||||.:|||
Human   805 TNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGRAGRTGPGQCFRLY 869

  Fly   872 TQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALD 936
            ||..||:|||..||||||||||||.|||||||||.||||||||||||:||:|||:||||||||||
Human   870 TQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQFHFMDPPPEDNMLNSMYQLWILGALD 934

  Fly   937 HTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVRE 1001
            :||.||:.||.|.||||||...:||||:|.||||:|:|:||||||||:|||||||||:|:|.:||
Human   935 NTGGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIVSMLSVPAIFYRPKGREEESDQIRE 999

  Fly  1002 KFQRPESDHLTYLNVYQQWRQNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGI 1066
            ||..||||||||||||.||:.||||:.|||:||||.||||||||||.||||||.||.:|:.|||.
Human  1000 KFAVPESDHLTYLNVYLQWKNNNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSLASCGT 1064

  Fly  1067 DWDIVRKCICSAYFYQAARLKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEY 1131
            ||||||||||:|||:|||:|||||||||:||||||||||||:|:|:|.||||:|||||:||.|||
Human  1065 DWDIVRKCICAAYFHQAAKLKGIGEYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHELVMTTKEY 1129

  Fly  1132 MQCATAVDGYWLAELGPMFFSVKESGRSGREKKKQAAEHLKEMEEQMLKAQHEMEERKQQAAERE 1196
            |||.|||||.|||||||||:|||::|:|.:|.:::|.|....|||:|..|:.::..|:|:..:|.
Human  1130 MQCVTAVDGEWLAELGPMFYSVKQAGKSRQENRRRAKEEASAMEEEMALAEEQLRARRQEQEKRS 1194

  Fly  1197 EQLATKQ-EIATPGN------ATPRRTPARIGL 1222
            ...:.:. :|.|||.      .||||||||.||
Human  1195 PLGSVRSTKIYTPGRKEQGEPMTPRRTPARFGL 1227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	491/613 (80%)
DHX38	NP_054722.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..320		95/295 (32%)
		HrpA	532..>1146	CDD:441249	491/613 (80%)
		DEAH box	652..655		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1155..1227		25/71 (35%)