DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and DHX38

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_054722.2	Gene:	DHX38 / 9785	HGNCID:	17211	Length:	1227	Species:	Homo sapiens

Alignment Length:	1271	Identity:	772/1271 - (60%)
Similarity:	951/1271 - (74%)	Gaps:	93/1271 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSD-DDESGVHRLEGTAGQETRGGLVIRKPKDAGAGGGGGFK--VPQGSMLGLDKLAAKRRAEKE 62
            |.| .:::.:||||||......|||:. |.|.| |.....||  .|:.|:||||.||:.:|.|:|
Human     1 MGDTSEDASIHRLEGTDLDCQVGGLIC-KSKSA-ASEQHVFKAPAPRPSLLGLDLLASLKRRERE 63

  Fly    63 RSERLISFKDSEFDDTGGGSSTPQANASGASSEFAFKKPDTKSFEKLRG-----------QLREH 116
                       |.||   |....::..| :..::...|.|.|..|:..|           ..|..
Human    64 -----------EKDD---GEDKKKSKVS-SYKDWEESKDDQKDAEEEGGDQAGQNIRKDRHYRSA 113

  Fly   117 KDDTPSHTGGVSEKARERLREHIQRDRKRGPVSSTAAEGRDRDRDWDRDRRRDRDRDRDRDRDRR 181
            :.:||||.|||||:..||.|:..:..|:.|..:|:..|     :||.:::.||||.||.||||
Human   114 RVETPSHPGGVSEEFWERSRQRERERREHGVYASSKEE-----KDWKKEKSRDRDYDRKRDRD-- 171

  Fly   182 QHRERERDRHRS-WDRDRGRDRDRDRSMSERSVHTPREPGTPGGSSGGISNSSWDDEDGEFG-QR 244
               ||:|.||.| .:||.|.:|...|:..|...|.|::..||       |.|:|::||..:| .|
Human   172 ---ERDRSRHSSRSERDGGSERSSRRNEPESPRHRPKDAATP-------SRSTWEEEDSGYGSSR 226

  Fly   245 KSDWDMPTP--------RRH--GNKSGDWSVRSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRS 299
            :|.|:.|:|        |.|  ..:..|.|||...|       |||..|||:::||:||..|:..
Human   227 RSQWESPSPTPSYRDSERSHRLSTRDRDRSVRGKYS-------DDTPLPTPSYKYNEWADDRRHL 284

  Fly   300 GATP----------WGEDPESLDL------WEEEQRRLDREWYNIDEGYDDENNPFGGPNSEYFR 348
            |:||          .||:..|.|.      ||::||:.||:||.:|||||:.:||....:.:|.|
Human   285 GSTPRLSRGRGRREEGEEGISFDTEEERQQWEDDQRQADRDWYMMDEGYDEFHNPLAYSSEDYVR 349

  Fly   349 KREEQLEQKRTKRISAQQRQNNRDNELWERNRMLTSGVVTLISVNDDFDEEALERVHLLVHHIIP 413
            :||:.|.:::.||||||:||.|.|||.||.|||||||||..:.|::||:|:...:|||:||:::|
Human   350 RREQHLHKQKQKRISAQRRQINEDNERWETNRMLTSGVVHRLEVDEDFEEDNAAKVHLMVHNLVP 414

  Fly   414 PFLDGRIVFTKQPEPVVPVKDPTSDMALLARKGSALVRNYREQKERRKAQKKHWELSGTKLGNIM 478
            ||||||||||||||||:||||.|||:|::|||||..||.:||||||:|||.|||||:|||||:||
Human   415 PFLDGRIVFTKQPEPVIPVKDATSDLAIIARKGSQTVRKHREQKERKKAQHKHWELAGTKLGDIM 479

  Fly   479 GVQRPQDEDDMRFDKEKDKADYRKDQKFADHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQEL 543
            ||::.::.|  :...|..|.|||.:|||||||: :.:...|:|::||:|.|||::||:||.:|||
Human   480 GVKKEEEPD--KAVTEDGKVDYRTEQKFADHMK-RKSEASSEFAKKKSILEQRQYLPIFAVQQEL 541

  Fly   544 LNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYSKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLG 608
            |.:||:||::|:|||||||||||||||||||||:..|||||||||||||||||||||:||...||
Human   542 LTIIRDNSIVIVVGETGSGKTTQLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLG 606

  Fly   609 EDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREI 673
            |:|||||||||||||.|:|||||||||||||||:.:||.||||||||||||||:||||||||||:
Human   607 EEVGYAIRFEDCTSENTLIKYMTDGILLRESLREADLDHYSAIIMDEAHERSLNTDVLFGLLREV 671

  Fly   674 VARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHL 738
            ||||.||||||||||||:.|||.||||||.|.|||||||||::|||...|||||:||||:|||||
Human   672 VARRSDLKLIVTSATMDAEKFAAFFGNVPIFHIPGRTFPVDILFSKTPQEDYVEAAVKQSLQVHL 736

  Fly   739 TPNEGDMLIFMPGQEDIEVTCEVLEERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKC 803
            :...||:|||||||||||||.:.:.|.|.|::|||||::||||||||||||||||||:.||:|||
Human   737 SGAPGDILIFMPGQEDIEVTSDQIVEHLEELENAPALAVLPIYSQLPSDLQAKIFQKAPDGVRKC 801

  Fly   804 VVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAY 868
            :|||||||||||||||::|||||||||||:|||||||||||||||||||||||||||||||||.:
Human   802 IVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGRAGRTGPGQCF 866

  Fly   869 RLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILG 933
            |||||..||:|||..||||||||||||.|||||||||.||||||||||||:||:|||:|||||||
Human   867 RLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQFHFMDPPPEDNMLNSMYQLWILG 931

  Fly   934 ALDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADG 998
            |||:||.||:.||.|.||||||...:||||:|.||||:|:|:||||||||:|||||||||:|:|.
Human   932 ALDNTGGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIVSMLSVPAIFYRPKGREEESDQ 996

  Fly   999 VREKFQRPESDHLTYLNVYQQWRQNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVIS 1063
            :||||..||||||||||||.||:.||||:.|||:||||.||||||||||.||||||.||.:|:.|
Human   997 IREKFAVPESDHLTYLNVYLQWKNNNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSLAS 1061

  Fly  1064 CGIDWDIVRKCICSAYFYQAARLKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTA 1128
            ||.||||||||||:|||:|||:|||||||||:||||||||||||:|:|:|.||||:|||||:||.
Human  1062 CGTDWDIVRKCICAAYFHQAAKLKGIGEYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHELVMTT 1126

  Fly  1129 KEYMQCATAVDGYWLAELGPMFFSVKESGRSGREKKKQAAEHLKEMEEQMLKAQHEMEERKQQAA 1193
            ||||||.|||||.|||||||||:|||::|:|.:|.:::|.|....|||:|..|:.::..|:|:..
Human  1127 KEYMQCVTAVDGEWLAELGPMFYSVKQAGKSRQENRRRAKEEASAMEEEMALAEEQLRARRQEQE 1191

  Fly  1194 EREEQLATKQ-EIATPGN------ATPRRTPARIGL 1222
            :|....:.:. :|.|||.      .||||||||.||
Human  1192 KRSPLGSVRSTKIYTPGRKEQGEPMTPRRTPARFGL 1227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	152/185 (82%)
		DEXDc	551..689	CDD:238005	117/137 (85%)
		HELICc	722..870	CDD:238034	119/147 (81%)
		HA2	932..1014	CDD:214852	59/81 (73%)
		OB_NTP_bind	1048..1148	CDD:285018	79/99 (80%)
DHX38	NP_054722.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..320		95/298 (32%)
		HrpA	515..1146	CDD:224557	499/630 (79%)
		DEAH box	652..655		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1155..1227		25/71 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147022
Domainoid	1	1.000	419	1.000	Domainoid score	I642
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8512
Inparanoid	1	1.050	1486	1.000	Inparanoid score	I104
Isobase	1	0.950	-	0	Normalized mean entropy	S613
OMA	1	1.010	-	-		QHG52596
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		oto90943
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R986
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.790