DRSC/TRiP Functional Genomics Resources

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Protein Alignment Prp16 and DHX34

DIOPT Version :10

Sequence 1:NP_572947.1 Gene:Prp16 / 32373 FlyBaseID:FBgn0026713 Length:1222 Species:Drosophila melanogaster
Sequence 2:NP_055496.2 Gene:DHX34 / 9704 HGNCID:16719 Length:1143 Species:Homo sapiens


Alignment Length:829 Identity:250/829 - (30%)
Similarity:380/829 - (45%) Gaps:152/829 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   250 MPTPRRHGNKSGDWSVRSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRSGATPWGEDPESLDLW 314
            ||.||          .|.|..||:|.|       .|:                    :.|:|:.|
Human     1 MPPPR----------TREGRDRRDHHR-------APS--------------------EEEALEKW 28

  Fly   315 E---EEQRRLDREWYNIDEGYDDENNPFGGPNSEYFRKREEQLEQKRTKRISAQQRQNNRDNELW 376
            :   .|.|||      :::.:..|        .:|.|:..|:.::..|.....|:.||.:.:...
Human    29 DWNCPETRRL------LEDAFFRE--------EDYIRQGSEECQKFWTFFERLQRFQNLKTSRKE 79

  Fly   377 ERNRMLTSGVVTLISVNDDFDEEALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMAL 441
            |::.....                         |.||...|....:..:....:.|..|      
Human    80 EKDPGQPK-------------------------HSIPALADLPRTYDPRYRINLSVLGP------ 113

  Fly   442 LARKGSALVRNYREQKERRKAQKKHWELSGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRKDQKF 506
             |.:||                        ..||..:..:|              .|::|:..  
Human   114 -ATRGS------------------------QGLGRHLPAER--------------VAEFRRAL-- 137

  Fly   507 ADHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYL 571
               :...|.|.|..|.|...:..:|..||:......:|..::|:.|:::.|:||.||:||:.|||
Human   138 ---LHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYL 199

  Fly   572 HEDGYSKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILL 636
            ...|:|.   :.||||||:|.:|:||||..|..:|.|..|||.||||...|..|.|.::|.|:||
Human   200 LAAGFSH---VACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLL 261

  Fly   637 RESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNV 701
            |:..|:|.|..|..:|:||.|||.|..|.|.|:|:.::..|.|||:|:.|||::.|.|:::|.|.
Human   262 RQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYFSNA 326

  Fly   702 PTFTIPGRTFPVDVMFSKNTCEDYVESAVK----------QALQVHLTPNE-GDMLIFMPGQEDI 755
            |...:|||.||:.|::.....|.....:.|          :::.....|.| ||:|:|:.|..:|
Human   327 PVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLVFLSGMAEI 391

  Fly   756 EVTCEVLEERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGII 820
            ..   |||.......:.....:||::|.|....|.|:|..:..|:|||:::|||||||:|:|||.
Human   392 SA---VLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILSTNIAETSVTIDGIR 453

  Fly   821 YVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTV 885
            :|:|||..|...|:|:..:..||.:.||||:|.||.|||||||||..:|||.:..| |......|
Human   454 FVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCFRLYAESDY-DAFAPYPV 517

  Fly   886 PEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAE 950
            |||:|..|.:.||.:||:.|.|...|.|::|||..::..::..|...||||.:.|||.:|..:|:
Human   518 PEIRRVALDSLVLQMKSMSVGDPRTFPFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQ 582

  Fly   951 FPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLN 1015
            .|:|....:|||:.........||.|.:.|||.|.|.|......|....|...:..:.|..|..|
Human   583 LPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTLFN 647

  Fly  1016 VYQQWRQ-----NNYSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNL 1059
            |:..|.|     :..|..||....|....:.::..:|:|.|:::....|
Human   648 VFNAWVQVKSERSRNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGL 696

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Prp16NP_572947.1 HrpA 534..>1148 CDD:441249 203/542 (37%)
DHX34NP_055496.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24 11/59 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 75..94 4/43 (9%)
HrpA 160..>624 CDD:441249 187/470 (40%)
DEAH box 279..282 2/2 (100%)
Negatively regulates interaction with UPF1. /evidence=ECO:0000269|PubMed:26841701 701..955
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 724..766
OB_NTP_bind 800..911 CDD:400182
Required for phosphorylation of UPF1. Not required for interaction with UPF1. /evidence=ECO:0000269|PubMed:26841701 810..1143
Required for the interaction with SMG1 and subsequent phosphorylation of UPF1. /evidence=ECO:0000269|PubMed:26841701 957..1143
Blue background indicates that the domain is not in the aligned region.

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