DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and DHX57

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_945314.1	Gene:	DHX57 / 90957	HGNCID:	20086	Length:	1386	Species:	Homo sapiens

Alignment Length:	1381	Identity:	312/1381 - (22%)
Similarity:	527/1381 - (38%)	Gaps:	443/1381 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 HTPREPGTPGGSSGG---------ISNSSWDDEDGEF-------------------GQRKSDW-- 248
            |..:..|:.||..||         .|:..|||.| :|                   |:.:..|
Human    29 HASKSHGSGGGGGGGGGGGGGNRKASSRIWDDGD-DFCIFSESRRPSRPSNSNISKGESRPKWKP 92

  Fly   249 --DMPTPRRHGNKSGDWSVRS-----------GGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRSG 300
              .:|....|........|::           .||.|....:::...|...:....|
Human    93 KAKVPLQTLHMTSENQEKVKALLRDLQEQDADAGSERGLSGEEEDDEPDCCNDERYW-------- 149

  Fly   301 ATPWGEDPE--------------SLDLWEEE-------QRRLDREWYNI------------DEGY 332
              |.|::|.              |::.:..|       .::|.|..:|.            |.|.
Human   150 --PAGQEPSLVPDLDPLEYAGLASVEPYVPEFTVSPFAVQKLSRYGFNTERCQAVLRMCDGDVGA 212

  Fly   333 DDEN---NPFGGPNSEYFRKR------------EEQLEQKR-----TKRISAQQRQNNRDNELWE 377
            ..|:   ..|    ||.|.:|            :|.:||::     .|.|..::......|.:|.
Human   213 SLEHLLTQCF----SETFGERMKISEAVNQISLDECMEQRQEEAFALKSICGEKFIERIQNRVWT 273

  Fly   378 ------------------------------------------------RNRMLTSGVVTLISVN- 393
                                                            ::.:..:.:|..|..:
Human   274 IGLELEYLTSRFRKSKPKESTKNVQENSLEICKFYLKGNCKFGSKCRFKHEVPPNQIVGRIERSV 338

  Fly   394 DDFDEEALERVHLLVH---------------------------------HIIPPFLDGRIVFTKQ 425
            ||....|:|....|..                                 ||.....|..:.|.:.
Human   339 DDSHLNAIEDASFLYELEIRFSKDHKYPYQAPLVAFYSTNENLPLACRLHISEFLYDKALTFAET 403

  Fly   426 PEPVVPVKDPTSDMALLARKGSALVR--------------NYREQKERRKAQKKHWELSGTKLGN 476
            .||||      ..:..|..:.|.:|:              |:.....|.:........:.....:
Human   404 SEPVV------YSLITLLEEESEIVKLLTNTHHKYSDPPVNFLPVPSRTRINNPACHKTVIPNNS 462

  Fly   477 IMGVQRPQ----------DEDD--------------------MRFDKEKDKADYRKDQKFADHMR 511
            .:..|.|:          ||||                    .|:|.:. |:.:.::.|.....|
Human   463 FVSNQIPEVEKASESEESDEDDGPAPVIVENESYVNLKKKISKRYDWQA-KSVHAENGKICKQFR 526

  Fly   512 DQDTGGKSDFSRK-KTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDG 575
            .:..      ||: ::|.::|:.||.:..|:.:||::|::.|::|.|.||.|||||:.|::.:|.
Human   527 MKQA------SRQFQSILQERQSLPAWEERETILNLLRKHQVVVISGMTGCGKTTQIPQFILDDS 585

  Fly   576 YS----KRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILL 636
            .:    |...|.||||||::|:|||:||:.|...::|..|||.||.|...|..|.:.|.|.|:||
Human   586 LNGPPEKVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLL 650

  Fly   637 RESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNV 701
            |....|..|...|.||:||.|||:..:|.|..:|::||::|..|::|:.|||:::..|:.:|.:.
Human   651 RRLEGDTALQGVSHIIVDEVHERTEESDFLLLVLKDIVSQRPGLQVILMSATLNAELFSDYFNSC 715

  Fly   702 PTFTIPGRTFPVDVMFSKNTC-------------------------------------------- 722
            |..||||||||||..|.::..
Human   716 PVITIPGRTFPVDQFFLEDAIAVTRYVLQDGSPYMRSMKQISKEKLKARRNRTAFEEVEEDLRLS 780

  Fly   723 -----EDYVESAV-------KQAL--------------------QVHLTPNE------------- 742
                 :|.|:.||       ||.|                    :|:|...|
Human   781 LHLQDQDSVKDAVPDQQLDFKQLLARYKGVSKSVIKTMSIMDFEKVNLELIEALLEWIVDGKHSY 845

  Fly   743 --GDMLIFMPGQEDIEVTCEVLEER-LAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCV 804
              |.:|:|:||..:|::..|.|:.. |.....:....|.|::|.|.|:.|..:|.|...|:.|.:
Human   846 PPGAILVFLPGLAEIKMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPAGVTKII 910

  Fly   805 VATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYR 869
            ::|||||||:|:|.::||||||..|.|.|:...||::|:...:|||||.||.|||||...|..:.
Human   911 ISTNIAETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFH 975

  Fly   870 LYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFH--------FMDPPPQDNILNSL 926
            |:|...|..:||...:|||||..|....|.:|   ::::...|        .::||..|::..|.
Human   976 LFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIK---ILEMFSAHNLQSVFSRLIEPPHTDSLRASK 1037

  Fly   927 YQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKG 991
            .:|..||||.....||.||..:|..|:|....::::......|....|.|.:.|:..|.|..|..
Human  1038 IRLRDLGALTPDERLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWD 1102

  Fly   992 REDEADGVREKFQRPESDHLTYLNVYQQWRQN-----NYSSTWCNEHFIHIKAMRKVREVRQQLK 1051
            :::||:..:.:|....||:|..|..|:.|:.:     ..|..:|.::|:..:.::::..:::|..
Human  1103 KKEEANQKKLEFAFANSDYLALLQAYKGWQLSTKEGVRASYNYCRQNFLSGRVLQEMASLKRQFT 1167

  Fly  1052 DIMTQ-----------------------------------QNLSVISCGIDWDIVRKCICSAYFY 1081
            ::::.                                   :|..:||.         .:|:|.:.
Human  1168 ELLSDIGFAREGLRAREIEKRAQGGDGVLDATGEEANSNAENPKLISA---------MLCAALYP 1223

  Fly  1082 QAARLKG-IGEYVNLRTG----MP--------------CHLHPTSALYGLG--TTPDYVVYHELI 1125
            ...::|. .|::....||    .|              .|:||:|..|.:.  .:| |::|||.|
Human  1224 NVVQVKSPEGKFQKTSTGAVRMQPKSAELKFVTKNDGYVHIHPSSVNYQVRHFDSP-YLLYHEKI 1287

  Fly  1126 MTAKEYMQCATAVDGYWLAELGPMFFSVKESGRSGREKKKQAAEHLKEMEE---QMLKAQHEMEE 1187
            .|::.:::..:.|..|.|...|....:|          :.|..|.:..:::   :.:.|.|::.|
Human  1288 KTSRVFIRDCSMVSVYPLVLFGGGQVNV----------QLQRGEFVVSLDDGWIRFVAASHQVAE 1342

  Fly  1188 R-KQQAAEREEQLATK 1202
            . |:...|.::.|..|
Human  1343 LVKELRCELDQLLQDK 1358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	82/189 (43%)
		DEXDc	551..689	CDD:238005	62/141 (44%)
		HELICc	722..870	CDD:238034	63/239 (26%)
		HA2	932..1014	CDD:214852	24/81 (30%)
		OB_NTP_bind	1048..1148	CDD:285018	26/155 (17%)
DHX57	NP_945314.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..106		16/77 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..147		4/26 (15%)
		UBA_DHX57	181..218	CDD:270502	6/36 (17%)
		RWD	243..418	CDD:283440	23/180 (13%)
		ZnF_C3H1	303..323	CDD:214632	0/19 (0%)
		DEXDc	550..730	CDD:214692	80/179 (45%)
		DEXDc	561..703	CDD:238005	62/141 (44%)
		DEVH box	668..671		2/2 (100%)
		Helicase_C	832..968	CDD:278689	52/135 (39%)
		HA2	1043..1125	CDD:214852	24/81 (30%)
		OB_NTP_bind	1164..1310	CDD:285018	26/155 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810