DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and PRP22

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_010929.3	Gene:	PRP22 / 856732	SGDID:	S000000815	Length:	1145	Species:	Saccharomyces cerevisiae

Alignment Length:	946	Identity:	385/946 - (40%)
Similarity:	573/946 - (60%)	Gaps:	79/946 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 SGDWSVRSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRSGATPWGEDPESLDLWEEEQRRLDRE 324
            ||:...|:..|..:.||.:|      ||......:..||...|    .||.   ||..| .:...
Yeast   256 SGEIRKRNTESVEDRGRSND------AHTSRNMKNKIKRRALT----SPER---WEIRQ-LIASG 306

  Fly   325 WYNIDEGYDD--ENNPFGGPNSEYF-RKREE-QLEQKRTKRISAQQRQNNRDNELWERNRMLTSG 385
            ..:||: |.:  :..|.   |:.|. .||:: .:....|:::         |::|.|:.|..|..
Yeast   307 AASIDD-YPELKDEIPI---NTSYLTAKRDDGSIVNGNTEKV---------DSKLEEQQRDETDE 358

  Fly   386 VVTLISVNDDFDEEALERVHLLVHHIIPPFL-DGRIVFTKQPEPVVPVKDPTSDMALLARKGSAL 449
            :...::.:|.                 |.|| |.::...|:.|.....|.|...|...|..||..
Yeast   359 IDVELNTDDG-----------------PKFLKDQQVKGAKKYEMPKITKVPRGFMNRSAINGSNA 406

  Fly   450 VRNYREQKERRKAQKKHWELSGTKLGNIMGVQRPQDEDDMRFDKEKDKADYR------KDQKFAD 508
            :|::||:|.|:|.:.:            ..:::.|..|    |..|:|.|.|      |:|....
Yeast   407 IRDHREEKLRKKREIE------------QQIRKQQSFD----DPTKNKKDSRNEIQMLKNQLIVT 455

  Fly   509 HMRDQDTGGKSDFSRKKT--ISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYL 571
            ............:.::.:  ||.||:.|||:|.|.||:..:|:|..::||||||||||||:||||
Yeast   456 EWEKNRMNESISYGKRTSLPISAQRQTLPVYAMRSELIQAVRDNQFLVIVGETGSGKTTQITQYL 520

  Fly   572 HEDGYSKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILL 636
            .|:|:|..|||||||||||||:||||||::|:..::|.||||.|||||.|...|.|||||||:|.
Yeast   521 DEEGFSNYGMIGCTQPRRVAAVSVAKRVAEEVGCKVGHDVGYTIRFEDVTGPDTRIKYMTDGMLQ 585

  Fly   637 RESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNV 701
            ||:|.|||:..||.|::||||||:::|||||.||::...:|.:||:||||||::|:||:.:|.|.
Yeast   586 REALLDPEMSKYSVIMLDEAHERTVATDVLFALLKKAAIKRPELKVIVTSATLNSAKFSEYFLNC 650

  Fly   702 PTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQEDIEVTCEVLEERL 766
            |...|||:||||:|::|:....||:|:|:...:.:|:....||:|:|:.|||:|:..||:|.:|:
Yeast   651 PIINIPGKTFPVEVLYSQTPQMDYIEAALDCVIDIHINEGPGDILVFLTGQEEIDSCCEILYDRV 715

  Fly   767 AEI-DNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKL 830
            ..: |:...|.|||:||.|||::|:|||:.:..|.||.|.||||||||:|:|||.||:|.|:.|:
Yeast   716 KTLGDSIGELLILPVYSALPSEIQSKIFEPTPKGSRKVVFATNIAETSITIDGIYYVVDPGFAKI 780

  Fly   831 KVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLAN 895
            .:||.|.|::.|.:.|||||.||||.|||||||||:.|||||:..:.:|:|..|||||||.||::
Yeast   781 NIYNARAGIEQLIVSPISQAQANQRKGRAGRTGPGKCYRLYTESAFYNEMLENTVPEIQRQNLSH 845

  Fly   896 TVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQM 960
            |:|:||::|:.|||:|.||||||::.:||:|.:|:.|.:||..|.||.||::|:.||:||...:.
Yeast   846 TILMLKAMGINDLLKFDFMDPPPKNLMLNALTELYHLQSLDDEGKLTNLGKEMSLFPMDPTLSRS 910

  Fly   961 LIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNY 1025
            |:.:....||.|::.|:|||||.::|||||.|:.|||..:.||..|..||||.||||.:|:|.||
Yeast   911 LLSSVDNQCSDEIVTIISMLSVQNVFYRPKDRQLEADSKKAKFHHPYGDHLTLLNVYTRWQQANY 975

  Fly  1026 SSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIVRKCICSAYFYQAARLKGIG 1090
            |..:|..:|:|.:.:::.|:|:.|:..|..:..|.:|||..|.|::||...|.:|..||:.....
Yeast   976 SEQYCKTNFLHFRHLKRARDVKSQISMIFKKIGLKLISCHSDPDLIRKTFVSGFFMNAAKRDSQV 1040

  Fly  1091 EYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSVKE 1155
            .|..:..|....:||:|:||  |...:||:||.:::|::|||...|:::..||.|:.|.|:...:
Yeast  1041 GYKTINGGTEVGIHPSSSLY--GKEYEYVMYHSIVLTSREYMSQVTSIEPQWLLEVAPHFYKAGD 1103

  Fly  1156 SGRSGREKKKQAAEHLKEMEEQ---MLKAQHEMEER 1188
            :....|:|.|....|.|..::|   .|.:..:..||
Yeast  1104 AESQSRKKAKIIPLHNKFAKDQNSWRLSSIRQSRER 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	114/185 (62%)
		DEXDc	551..689	CDD:238005	89/137 (65%)
		HELICc	722..870	CDD:238034	76/148 (51%)
		HA2	932..1014	CDD:214852	39/81 (48%)
		OB_NTP_bind	1048..1148	CDD:285018	34/99 (34%)
PRP22	NP_010929.3	Pnp	1..423	CDD:224106	50/222 (23%)
PRP22	NP_010929.3	HrpA	456..1145	CDD:224557	326/686 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
TreeFam	0	0.000	Not matched by this tool.
	5	4.710