Protein Alignment Prp16 and PRP2

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: NP_014408.1
• Gene: PRP2 / 855745
• SGDID: S000005294
• Length: 876
• Species: Saccharomyces cerevisiae
• Alignment Length: 943
• Identity: 344/943 - (36%)
• Similarity: 494/943 - (52%)
• Gaps: 138/943 - (14%)

  Fly   270 SRRNHGRQDDTVRPTPAHRYNQWAHGRKRSGATPWGEDPESLDLWEEEQRRLDREWYNIDEGYDD 334
            :|:|    |:.||..|:....:              ||.|:.|  :....:|.|..|:.::.:.:
Yeast    20 TRQN----DNAVRIEPSSLGEE--------------EDKEAKD--KNSALQLKRSRYDPNKVFSN 64

  Fly   335 ENNPFGGPNSEYFRKREEQLEQKRTKRISAQQRQNNRDNELWERNRML--TSGVVTLISVNDDFD 397
            .|.   ||..... |.|:...||::.:...:...|   |||..:..:|  :.......|.|..|:
Yeast    65 TNQ---GPEKNNL-KGEQLGSQKKSSKYDEKITSN---NELTTKKGLLGDSENETKYASSNSKFN 122

  Fly   398 EEALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMALLARKGSALVRNYREQKERRKA 462
            .|...::                                                 :..||..|.
Yeast   123 VEVTHKI-------------------------------------------------KNAKEIDKI 138

  Fly   463 QKKH-WELSGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRKD-QKFADHMRDQD----------- 514
            .::. ||  ..:|.|.|..| ....||:..: ..||.||..| ....|:..::|
Yeast   139 NRQRMWE--EQQLRNAMAGQ-SDHPDDITLE-GSDKYDYVFDTDAMIDYTNEEDDLLPEEKLQYE 199

  Fly   515 ----TGGKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDG 575
                ...:::..|..||.|.|:.|||...:.|||..|::|.|:||:|||||||||||.|||.|||
Yeast   200 ARLAQALETEEKRILTIQEARKLLPVHQYKDELLQEIKKNQVLIIMGETGSGKTTQLPQYLVEDG 264

  Fly   576 YSKRG--MIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFED-CTSERTVIKYMTDGILLR 637
            ::.:|  .|..||||||||.|||.||:|||:..||::|||.||||| .|..:||:||||||:|||
Yeast   265 FTDQGKLQIAITQPRRVAATSVAARVADEMNVVLGKEVGYQIRFEDKTTPNKTVLKYMTDGMLLR 329

  Fly   638 ESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVP 702
            |.|.|.:|..||.|::||||||:|:||:|.|||::|:.:|..|||:::||||::.||:.||.|.|
Yeast   330 EFLTDSKLSKYSCIMIDEAHERTLATDILIGLLKDILPQRPTLKLLISSATMNAKKFSEFFDNCP 394

  Fly   703 TFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPN-EGDMLIFMPGQEDIEVTCEVLEERL 766
            .|.:|||.:|||:.::.....:|:.:|:....|:|.|.: .||:|:|:.|||:||.|...|||.:
Yeast   395 IFNVPGRRYPVDIHYTLQPEANYIHAAITTIFQIHTTQSLPGDILVFLTGQEEIERTKTKLEEIM 459

  Fly   767 AEI-DNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKL 830
            ::: .....:.|.|||:.||.:.|.||||.:.:..||.|:||||||||||:|||.||||.|:.|.
Yeast   460 SKLGSRTKQMIITPIYANLPQEQQLKIFQPTPENCRKVVLATNIAETSLTIDGIRYVIDPGFVKE 524

  Fly   831 KVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLAN 895
            ..|.|..||..|...|.|:|:.:||:|||||.|||:.:|::|:..|..||..:..|||.||||:|
Yeast   525 NSYVPSTGMTQLLTVPCSRASVDQRAGRAGRVGPGKCFRIFTKWSYLHELELMPKPEITRTNLSN 589

  Fly   896 TVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQM 960
            |||||.||||.||::|..||.|....:..||..|:|||||:..|.:|.||:.|.|||.:|...::
Yeast   590 TVLLLLSLGVTDLIKFPLMDKPSIPTLRKSLENLYILGALNSKGTITRLGKMMCEFPCEPEFAKV 654

  Fly   961 LIVA-----CRMGCSAEVLIIVSML-SVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQ 1019
            |..|     |: |...|.|.||||| ..||:|...|     .|.........||||:.||.::.|
Yeast   655 LYTAATHEQCQ-GVLEECLTIVSMLHETPSLFIGQK-----RDAAASVLSEVESDHILYLEIFNQ 713

  Fly  1020 WRQNNYSSTWCNEHFIHIKAMRKVREVRQQL-----------KDIMTQQNLSVISCGIDWDIVRK 1073
            ||.:.:|.:||.:|.|..|.|.:||.:|.||           |:...:..:..|:..|:..|.|
Yeast   714 WRNSKFSRSWCQDHKIQFKTMLRVRNIRNQLFRCSEKVGLVEKNDQARMKIGNIAGYINARITR- 777

  Fly  1074 CICSAYFYQAARLKGIGEYVNLRT--GMPCHLHPTSALY----GLGTTPD-YVVYHELIMTAKEY 1131
            |..|.:.....:|...|.....|:  |:...:||||.|:    .....|. ||:|.:|::|:||:
Yeast   778 CFISGFPMNIVQLGPTGYQTMGRSSGGLNVSVHPTSILFVNHKEKAQRPSKYVLYQQLMLTSKEF 842

  Fly  1132 MQ-CATAVDGYWLAELGPMFFS--VKESGRSGR 1161
            :: |.......||.::.|..|.  :.:....||
Yeast   843 IRDCLVIPKEEWLIDMVPQIFKDLIDDKTNRGR 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	288/643 (45%)
PRP2	NP_014408.1	PTZ00121	<7..174	CDD:173412	43/233 (18%)
		HrpA	223..>738	CDD:441249	256/520 (49%)
		OB_NTP_bind	775..862	CDD:400182	25/87 (29%)