Protein Alignment Prp16 and ECM16

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: NP_013847.1
• Gene: ECM16 / 855158
• SGDID: S000004735
• Length: 1267
• Species: Saccharomyces cerevisiae
• Alignment Length: 1305
• Identity: 346/1305 - (26%)
• Similarity: 545/1305 - (41%)
• Gaps: 359/1305 - (27%)

  Fly    56 KRRAEKERSERLISFKD------SEF-------------DDTGGGSSTPQANASGASSEFAFKKP 101
            ||..||.||..:...|:      .:|             |.....|||.:.||:....|     |
Yeast     6 KRFNEKARSGHMAKLKELKRIRNKQFTRQDENDERVENPDSAPAESSTTEPNANAEILE-----P 65

  Fly   102 DTKSFEKL-RGQLREHKDDTPSHTGGVSEKARERLREH-IQRDRKRGPVSSTAAEGRDRDRDWDR 164
            .|:..:|: :.:|:|......|....:.:|..::..|| ::|:.::..:      |:.:|...|.
Yeast    66 LTEEEKKMKKRKLQELFTPKESKVSRLKKKRLDKFIEHQLKREERKTII------GKLQDYKIDT 124

  Fly   165 DRRRDRDRDRDRDRDRRQHRERERDRHRSWDRD-RGRDRDRDRSMSERSVHTPREPGTPGGSSGG 228
            ...    ....|..:.||.::.|.....|.:|. ||.::..:....|.......|.| .||||
Yeast   125 SLL----TSSKRLGEGRQTKKEEFKEALSLERQGRGNEQTNEILYEEYEPKVWDEYG-EGGSS-- 182

  Fly   229 ISNSSWDDEDGEFGQRKSDWDMPTPRRHGNKSGDWSV-----RSGGSRRNHGRQDDTV----RPT 284
                  :|:|||.....|...||.|..:..|.....:     :.|||..:.|..:..|    ..|
Yeast   183 ------EDDDGEDDFEASFGSMPKPTDNEEKKSSGFIDHRPAKFGGSGLSFGFSNIKVINKESKT 241

  Fly   285 PAHRYNQW----------AHGRKRSGATPWGEDPESLDLWEEEQRRLDREWYNIDEGYDDENNPF 339
            |..:|| |          .||:         ||....|...|:.   |.|   .|:..:|:.:|.
Yeast   242 PKKKYN-WRQRVEMEELKKHGK---------EDEMDFDTTSEDD---DEE---EDQEEEDKMHPS 290

  Fly   340 GGPNSEYFRKREEQLEQKRTKRISAQQRQNNRDNELWERNRMLTSGVVTLISVNDDFDEEALERV 404
            ..|        .|::|...::..|.:..||:..||.                  .|:..:.::::
Yeast   291 ENP--------LEEVESADSETGSEKFDQNDVANEF------------------KDWANQEIKKL 329

  Fly   405 HLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMALLARKGSALVRNYREQKERRKAQKKHWEL 469
            ......::.|.|:  |.:    :|::. |:...|
Yeast   330 EGRDQELVTPTLN--IDY----KPIIR-KEDLDD------------------------------- 356

  Fly   470 SGTKLGNIMGVQR---PQDEDDMRFDKEKDKADYRKDQKFADHMRDQDTGGKSDFSRKKTISEQR 531
                     |:|.   |.:|:..|      ||.|                  .:.||...|.:.|
Yeast   357 ---------GLQEAYVPINENSTR------KAFY------------------VEVSRSDEIQKAR 388

  Fly   532 RFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYSKR------GMIGCTQPRRV 590
            ..||||....:::..|..|.|:||.||||||||||:.|:|:|.|:...      ||:|.||||||
Yeast   389 IQLPVFGEEHKIMEAIHHNDVVIICGETGSGKTTQVPQFLYEAGFGAEDSPDYPGMVGITQPRRV 453

  Fly   591 AAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDE 655
            ||:|:|:||::|:... |..|||.|||:....|.|.:|:||||:||||.:.|.:|..||:||:||
Yeast   454 AAVSMAERVANELGDH-GHKVGYQIRFDSTAKEDTKVKFMTDGVLLREMMHDFKLTKYSSIIIDE 517

  Fly   656 AHERSLSTDVLFGLLREIV---ARRH--------DLKLIVTSATMDSSKFA---TFFGNV-PTFT 705
            ||||:::||:|.|:|...|   |:.|        .||||:.|||:..|.|:   |.|... |...
Yeast   518 AHERNINTDILIGMLSRCVRLRAKLHKENPIEHKKLKLIIMSATLRVSDFSENKTLFPIAPPVLQ 582

  Fly   706 IPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQ------------------ 752
            :..|.|||.:.|::.|..:|.:.|.::..::|.....|.:|:|:.||
Yeast   583 VDARQFPVSIHFNRRTAFNYTDEAFRKTCKIHQKLPPGAILVFLTGQQEITHMVKRLRKEFPFKK 647

  Fly   753 --------------------------EDIEVTCEVL----------------------------- 762
                                      |||:.:.:|:
Yeast   648 NSKYNKDLETPVSKMGINSKTTDLEAEDIDFSVQVIDQDKFKSAIRYEEDEGNSGNGEDEEDEEE 712

  Fly   763 ---EERLAEIDNA-PALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVI 823
               ||.|.|...| ..|.:||:||.||:..|.::|||...|.|.|:||||:||||||:.|:.||:
Yeast   713 EGFEEVLTEGQTANDPLYVLPLYSLLPTKEQMRVFQKPPQGSRLCIVATNVAETSLTIPGVRYVV 777

  Fly   824 DSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEI 888
            |||..|.:.||...|:.:.::..:|:|:||||||||||||||..||||:...::.:....:.|||
Yeast   778 DSGRSKERKYNESNGVQSFEVGWVSKASANQRSGRAGRTGPGHCYRLYSSAVFEHDFEQFSKPEI 842

  Fly   889 QRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPL 953
            .|..:.:.||.:||:.:.:::.|.|..||.:..:..::..|..|||||:...:|..|::|:.|||
Yeast   843 LRMPVESIVLQMKSMAIHNIINFPFPTPPDRVALSKAIQLLQYLGALDNKEMITEDGKKMSLFPL 907

  Fly   954 DPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFY------------RPKGREDEADGVRE----- 1001
            .|...:||:|:....|...::.|||.|||...|.            :|...|:..|.:||
Yeast   908 SPRFSKMLLVSDEKACLPYIVAIVSALSVGDPFINEFELGINEISRKPNPDENLDDKIREHDEST 972

  Fly  1002 -------------KFQRPE---------SDHLTYLNVY--QQWRQNNYSSTWCNEHFIHIKAMRK 1042
                         ||.:..         ||....|:|.  ..:........:..::|:..|.|.:
Yeast   973 PGMDPELKKELRSKFYKSRSQFSKLDKFSDVFRLLSVVSAMDYVPKEQKEIFMKKNFLRGKLMEE 1037

  Fly  1043 VREVRQQL----KDIMTQQNLSV----------ISCGIDWDIVRKCICSAY-----------FYQ 1082
            :.::|:||    |...:::|::|          |...|...::::.||:.:           |..
Yeast  1038 IVKLRKQLMYIIKSNTSKENIAVVIRNEDLKSDIPSVIQIKLLKQMICAGFVDHVAVRADVLFPD 1102

  Fly  1083 AARLKGIGEYVN------LRTGMP----C--HLHPTSALYGLG-TTPDYVVYHELIMTAKEYMQC 1134
            .|::......:|      |.|..|    |  ::||||.|..|| ..|.|::|:.|.:......:.
Yeast  1103 DAKITNRTSIINIPYIPVLATRTPNIEDCFVYIHPTSILNNLGEMPPKYMLYYSLHLGGNNKTRM 1167

  Fly  1135 ATAVD 1139
            .|..|
Yeast  1168 NTLCD 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	246/783 (31%)
ECM16	NP_013847.1	HrpA	390..>940	CDD:441249	201/550 (37%)
		HA2	879..1006	CDD:461295	33/126 (26%)
		OB_NTP_bind	1080..1184	CDD:400182	22/93 (24%)