DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)G0007 and DHR2

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_012845.1	Gene:	DHR2 / 853784	SGDID:	S000001561	Length:	735	Species:	Saccharomyces cerevisiae

Alignment Length:	757	Identity:	262/757 - (34%)
Similarity:	412/757 - (54%)	Gaps:	89/757 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 LLARKGSALVRNY--REQKERRKAQKKHWELSGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRKD 503
            :.|...|.:..|:  ::||.||..   |...:.|::                  |...|.....|
Yeast     1 MAANSNSRVASNHTSKKQKVRRNI---HPFTNNTRI------------------KRASKIVKFND 44

  Fly   504 QKFADHMRDQDTGG------KSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSG 562
            ....||:.||.:..      ||..||...:.:.|..|||:..::|:::.|..|.|.:::||||||
Yeast    45 SGEGDHVSDQRSNKENVLTYKSLKSRASDLLKMRETLPVYQHKREIMSYIESNPVTVLIGETGSG 109

  Fly   563 KTTQLTQYLHEDGY--SKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERT 625
            |:||:.|::.|..|  .|.|.|..||||||||:::|.||:.|...:|||.|||::||::.|:.||
Yeast   110 KSTQIPQFVLEKLYDTKKHGSIAVTQPRRVAAINLATRVAQEHGCKLGEQVGYSVRFDNTTTTRT 174

  Fly   626 VIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIV-ARRHDLKLIVTSATM 689
            .:||:|||:||||.:.:.:|..||.|::||||||::.||::.|.|:.:: ..|.||::||.|||:
Yeast   175 RLKYLTDGMLLRELMMNSDLREYSVIVIDEAHERTVLTDLILGFLKSLIQGPRPDLRIIVMSATL 239

  Fly   690 DSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQED 754
            .:.||:.||.|.|...:.||.|.|...:.|...:|.|::.::..:|::.....||:|.|:||||:
Yeast   240 QAEKFSEFFNNAPILFVEGRKFDVKQYYLKAPTDDIVDAVIRCCIQINQGEELGDILCFLPGQEE 304

  Fly   755 IEVTCEVLEERLAEI--DNAPALSIL--PIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLT 815
            |:....:: |::|:.  |.||...|:  |:|:.||:..|:.:|.......||.|.:|||||||:|
Yeast   305 IDKAVTIM-EKIAKYVSDEAPVPLIVPYPLYAALPAVQQSLVFAPIKGFKRKVVFSTNIAETSVT 368

  Fly   816 VDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDEL 880
            :.|:.:|:|||..|:||:..::|:..|...|||||:|.||||||||...|:::|||.:..|. :|
Yeast   369 ISGVKFVVDSGLRKVKVWRHQLGLATLLTVPISQASAMQRSGRAGRESEGKSFRLYCESDYV-KL 432

  Fly   881 LALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLG 945
            ...:.|||.|:::.:.||:||..||.|||.:.:.:.|.::.|:..|.:|:.|||||..|.:|..|
Yeast   433 PKQSEPEIARSDVTSPVLMLKRYGVDDLLNWTWFENPGKEAIVMGLQELYELGALDTRGKITKRG 497

  Fly   946 RQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDH 1010
            :|||..||.|....:||.|..:||.::|:.|||.|||.::...|.  .:|.|.|.|:       .
Yeast   498 QQMALLPLQPHLSSVLIKASEVGCLSQVIDIVSCLSVENLLLNPS--PEERDEVNER-------R 553

  Fly  1011 LTYLNV------------------YQQWRQNNYSS---TWCNEHFIHIKAMRKVREVRQQLKDIM 1054
            |:..|.                  |:..:..:.||   .||....|.|:..:.|..||.||: :.
Yeast   554 LSLCNAGKRYGDLIMLKELFDIYFYELGKSQDASSERNDWCKGLCISIRGFKNVIRVRDQLR-VY 617

  Fly  1055 TQQNLSVIS--------CGIDWDIVR---KCICSAYFYQAARLKGIG----EYVNLRTGMPCHLH 1104
            .::..|.||        .|.|.:::.   ||..:.:....|    ||    .|..:.||.|..:|
Yeast   618 CKRLFSSISEEDEESKKIGEDGELISKILKCFLTGFIKNTA----IGMPDRSYRTVSTGEPISIH 678

  Fly  1105 PTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAEL 1146
            |:|.|:...:.|. ::|.|.:.|.|.|.:..:.::..||.|:
Yeast   679 PSSMLFMNKSCPG-IMYTEYVFTTKGYARNVSRIELSWLQEV 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	87/188 (46%)
		DEXDc	551..689	CDD:238005	69/140 (49%)
		HELICc	722..870	CDD:238034	60/151 (40%)
		HA2	932..1014	CDD:214852	32/81 (40%)
		OB_NTP_bind	1048..1148	CDD:285018	29/114 (25%)
DHR2	NP_012845.1	HrpA	30..730	CDD:224557	254/725 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.770