DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and PRP43

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_011395.1	Gene:	PRP43 / 852757	SGDID:	S000003088	Length:	767	Species:	Saccharomyces cerevisiae

Alignment Length:	788	Identity:	305/788 - (38%)
Similarity:	481/788 - (61%)	Gaps:	59/788 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 TKQPEPV-VPVKDPTSDMALLARKGSALVRNYREQKERRKAQKKHWELSGTKLGNIMGVQRPQDE 486
            ::.|:|| ..:.:..:::|              |:..::........|.....|...|:||....
Yeast     9 SEHPDPVETSIPEQAAEIA--------------EELSKQHPLPSEEPLVHHDAGEFKGLQRHHTS 59

  Fly   487 DDMRFDKEKDKADYRKDQKFADHMRDQDTGGKSDFSRKKT-ISEQRRFLPVFASRQELLNVIREN 550
            .:             :.||..|...:..||  .:|:.|.. |.:.||.|||.|.|.|.|.:.:.|
Yeast    60 AE-------------EAQKLEDGKINPFTG--REFTPKYVDILKIRRELPVHAQRDEFLKLYQNN 109

  Fly   551 SVIIIVGETGSGKTTQLTQYL--HEDGYSKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGY 613
            .:::.|||||||||||:.|::  .|..:.:...:.|||||||||||||:||::|||.:|||:|||
Yeast   110 QIMVFVGETGSGKTTQIPQFVLFDEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEVGY 174

  Fly   614 AIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRH 678
            :||||:.||.:|::||||||:||||::.|.:|..||.||:||||||:|:||:|.|||:::|.||.
Yeast   175 SIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRP 239

  Fly   679 DLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEG 743
            |||:|:.|||:|:.||..:|.:.|...:||||:||::.::.....||::||::..||:|.|...|
Yeast   240 DLKIIIMSATLDAEKFQRYFNDAPLLAVPGRTYPVELYYTPEFQRDYLDSAIRTVLQIHATEEAG 304

  Fly   744 DMLIFMPGQEDIEVTCEVLE---ERLAEIDNAPALSILPIYSQLPSDLQAKIFQ---KSSDGL-- 800
            |:|:|:.|:::||.....:.   ::|...:....||:.|:|..||...|.:||:   :|.:|.
Yeast   305 DILLFLTGEDEIEDAVRKISLEGDQLVREEGCGPLSVYPLYGSLPPHQQQRIFEPAPESHNGRPG 369

  Fly   801 RKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPG 865
            ||.|::|||||||||:|||:||:|.|:.|.|||||||.:::|.:.|||:|:|.||:||||||.||
Yeast   370 RKVVISTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPG 434

  Fly   866 QAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLW 930
            :.:||||:..::.||:..:.|||.|:||::|||.||.||:.||:.|.|||||..:.::.:|.:|.
Yeast   435 KCFRLYTEEAFQKELIEQSYPEILRSNLSSTVLELKKLGIDDLVHFDFMDPPAPETMMRALEELN 499

  Fly   931 ILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDE 995
            .|..||..|.||.|||..::|||||....|||.:....||.|:|.||:|||||::|.||...:..
Yeast   500 YLACLDDEGNLTPLGRLASQFPLDPMLAVMLIGSFEFQCSQEILTIVAMLSVPNVFIRPTKDKKR 564

  Fly   996 ADGVREKFQRPESDHLTYLNVYQQWRQN---NYS-STWCNEHFIHIKAMRKVREVRQQLKDIMTQ 1056
            ||..:..|..|:.||:|.||||..::.:   .|. ..||.:|:::.:::.....:|.||:.:|.:
Yeast   565 ADDAKNIFAHPDGDHITLLNVYHAFKSDEAYEYGIHKWCRDHYLNYRSLSAADNIRSQLERLMNR 629

  Fly  1057 QNLSVISCGID----WDIVRKCICSAYFYQAARLK-GIGEYVNLRTGMPCHLHPTSALYGLGTTP 1116
            .||.:.:...:    :|.:||.:.|.:|.|.|:.: |...|:.::......:||::.   ||...
Yeast   630 YNLELNTTDYESPKYFDNIRKALASGFFMQVAKKRSGAKGYITVKDNQDVLIHPSTV---LGHDA 691

  Fly  1117 DYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSV----KESGRSGREKKKQAAEHLKEMEE- 1176
            ::|:|:|.::|:|.|::..|:|...||.|:.|.::.:    |...:...|:.|:..:.|.|:::
Yeast   692 EWVIYNEFVLTSKNYIRTVTSVRPEWLIEIAPAYYDLSNFQKGDVKLSLERIKEKVDRLNELKQG 756

  Fly  1177 -QMLKAQH 1183
             ...|::|
Yeast   757 KNKKKSKH 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	104/187 (56%)
		DEXDc	551..689	CDD:238005	82/139 (59%)
		HELICc	722..870	CDD:238034	70/155 (45%)
		HA2	932..1014	CDD:214852	38/81 (47%)
		OB_NTP_bind	1048..1148	CDD:285018	29/104 (28%)
PRP43	NP_011395.1	HrpA	55..753	CDD:224557	293/715 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
TreeFam	0	0.000	Not matched by this tool.
	5	4.710