DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and YLR419W

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_013523.3	Gene:	YLR419W / 851137	SGDID:	S000004411	Length:	1435	Species:	Saccharomyces cerevisiae

Alignment Length:	887	Identity:	228/887 - (25%)
Similarity:	400/887 - (45%)	Gaps:	192/887 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 DPESLDLWEEEQRRLDREWYNIDEG--YDDENNPFGGPNSEYFRKREEQLEQK----RTKRISAQ 365
            :.||::.|.:|...|:    :|.||  .|.:.      :|.|.....|:|:.|    |||...|.
Yeast   421 ETESIECWNQELESLE----SIYEGCVMDAKE------DSHYTLNLIEKLKIKLKVYRTKNYPAS 475

  Fly   366 QRQNNRDNELWERNRMLTSGVVTLISVN----DDFDEEALERV-----------HLLVHHIIPPF 415
                            |...||:....|    |...::.|.|:           .:||:||....
Yeast   476 ----------------LPGIVVSTFDKNYKLPDYIKKQILTRLLHYLQEGNLIGDMLVYHIYEWL 524

  Fly   416 LDGRIVFTKQPEPVVPVKDPTSDMALLARKGSALVRNYREQKE--RRKAQKKHWELSGTKLGNIM 478
            .:........|.|::|..|         .||:...||....|.  ...:.:|   .:.|.:
Yeast   525 KENISKIIDNPGPLIPDSD---------SKGAINKRNISNGKRSINNSSSRK---FTKTTI---- 573

  Fly   479 GVQRPQDEDDMRFDKEKDKADYRKDQKFADHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQEL 543
                  .||.:...:|    :|.|..|            .|::...:.:.||   ||.:..::.:
Yeast   574 ------SEDTLSVLRE----EYTKRIK------------SSEYKSMQLVREQ---LPAWKKQKVI 613

  Fly   544 LNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYSKRGMIG-----CTQPRRVAAMSVAKRVSDEM 603
            :::|.:|.|::|.|||||||:||:.|::.:....::|..|     ||||||::|:.:|:|||||.
Yeast   614 IDIINKNEVVLITGETGSGKSTQVVQFILDFLQKEKGDFGKTKIVCTQPRRISAIGLAERVSDER 678

  Fly   604 DTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFG 668
            ....||:|||.||..:.|...|.||:||.|:|:|.......:...:.:::||.||||:.||::..
Yeast   679 CVTCGEEVGYVIRGVNKTKASTRIKFMTTGVLVRLLQNARTMLENTIVVIDEVHERSIDTDLIVT 743

  Fly   669 LLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCED--------- 724
            |::.::.|...:|:::.|||::...|..||..:.|..|.|||||:...|.::...|
Yeast   744 LMKNLLHRVRGMKIVLMSATVNVDLFKKFFPGLATCHIEGRTFPITDYFLEDILSDLDFKIKREK 808

  Fly   725 -------------------------------------------YVESAVKQALQVHLTPNEGDML 746
                                                       ||...:|.|      .:.|.::
Yeast   809 ALSYDDDSVDERNNDDQYLKPRADSKFFTSGQINYDLLCQVVEYVHKRLKAA------NDNGSII 867

  Fly   747 IFMPGQEDIEVTCEVLEERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAE 811
            :|:||..:|...|.:|..:..|.|    ..:||::|.|..:.|.::|:| ..|.||.||:|||||
Yeast   868 VFLPGVGEINKCCNLLANKSNEAD----FMVLPLHSALTPEDQKRVFKK-YHGKRKVVVSTNIAE 927

  Fly   812 TSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQY 876
            ||:|:|..:..||:|..|...|||:.....|....||:|...||.|||||...|.:|:|:::..|
Yeast   928 TSITIDDCVATIDTGRAKSMFYNPKDNTTKLIESFISKAEVKQRRGRAGRVREGLSYKLFSKNLY 992

  Fly   877 KDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQF--HFMDPPPQDNILNSLYQLWILGALDHTG 939
            :::::::.:|||:|..|.:..|.:|::|:.|:..|  ..:|.||...:..:...|..:|.:|.:.
Yeast   993 ENDMISMPIPEIKRIPLESLYLSVKAMGIKDVKAFLSTALDAPPLPALQKAERILTTIGLVDESD 1057

  Fly   940 -ALTTLGRQMAEFP-LDPPQCQMLIVACRMGCSAEVLIIVSMLSV---PSIFYRPKGREDEADGV 999
             :||.||:.::..| :|....::||.....||:...:::||:|.:   |.|     |..:..:.:
Yeast  1058 KSLTQLGQFISLMPVMDSKHGKLLIYGILFGCTDISVLLVSILGIGVLPFI-----GGFENREKI 1117

  Fly  1000 REKFQRPES--DHLTYLNV---YQQWRQNNYSSTWCNEHFIHIKAMRKVREVRQQ-------LKD 1052
            ::...:.||  |....|.:   |.:.:.::....:..::.:   :..|:.|::..       |||
Yeast  1118 KKLLCKYESRGDLFAVLEIVRDYFKIKDSSIKRKYLRDNLL---SYNKINEIKSSTAQYYSILKD 1179

  Fly  1053 I----MTQQNLSVISCG---IDWDIVRKCICSAYFYQAARLK 1087
            :    |..:..|:....   .::||:|..:..|::...||::
Yeast  1180 VGFLPMDYKVGSISDLNRNERNFDILRAILTGAFYPHIARVQ 1221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	73/190 (38%)
		DEXDc	551..689	CDD:238005	56/142 (39%)
		HELICc	722..870	CDD:238034	55/199 (28%)
		HA2	932..1014	CDD:214852	21/88 (24%)
		OB_NTP_bind	1048..1148	CDD:285018	11/54 (20%)
YLR419W	NP_013523.3	UBA_YLR419W_like	369..409	CDD:270457
		RWD	426..528	CDD:399058	27/127 (21%)
		HrpA	563..1428	CDD:224557	190/710 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810