DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and DHX16

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_003578.2	Gene:	DHX16 / 8449	HGNCID:	2739	Length:	1041	Species:	Homo sapiens

Alignment Length:	1207	Identity:	436/1207 - (36%)
Similarity:	640/1207 - (53%)	Gaps:	229/1207 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LEGTAGQETRGGLVIRKPKDAG----AGGGGGF------KVPQGSMLGLDKLAAKRRA----EKE 62
            |.|||.:.|.....:::.:|..    :|....|      |||:.:::.....||:|.|    ||.
Human    30 LIGTAQRCTSAEEFVQRLRDTDTLDLSGPARDFALRLWNKVPRKAVVEKPARAAEREARALLEKN 94

  Fly    63 RSERLISFKDSEFDDTGGGSSTPQANASGASSEFAFKKPDTKSFEKLRGQLREHKDDTPSHTGGV 127
            ||.||:  :|||      .||....:.:|:|.:   ||      .|.|..||:.:::
Human    95 RSYRLL--EDSE------ESSEETVSRAGSSLQ---KK------RKKRKHLRKKREE-------- 134

  Fly   128 SEKARERLREHIQRDRKRGPVSSTAAEGRDRDRDWDRDRRRDRDRDRDRDRDRRQHRERERDRHR 192
                 |...|..::.:|:...|....|..:.:.:|:|           .:|:|.|..| |||...
Human   135 -----EEEEEASEKGKKKTGGSKQQTEKPESEDEWER-----------TERERLQDLE-ERDAFA 182

  Fly   193 SWDRDRGRDRDRDRSMSERSVHTPREPGTPGGSSGGISNSSWDDEDGEFGQRKSDWDMPTPRRHG 257
              :|.|.||:||.|::.|||                 ...::::........:.|.....|....
Human   183 --ERVRQRDKDRTRNVLERS-----------------DKKAYEEAQKRLKMAEEDRKAMVPELRK 228

  Fly   258 NKSGDWSVRSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRSGATPWGEDPESLDLWEEEQRRLD 322
            .           |||.:                                      |.:.|:.:|:
Human   229 K-----------SRREY--------------------------------------LAKREREKLE 244

  Fly   323 REWYNIDEGYDDENNPFGGPNSEYFRKREEQLEQKRTKR-ISAQQRQNNRDNELWERNRMLTSGV 386
                :::....||...||  :.|..|...::|:.||..| ::.:.|......:|
Human   245 ----DLEAELADEEFLFG--DVELSRHERQELKYKRRVRDLAREYRAAGEQEKL----------- 292

  Fly   387 VTLISVNDDFDEEALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMALLARKGSALVR 451
                        ||..|.|:      |....|      ||...|.:.:
Human   293 ------------EATNRYHM------PKETRG------QPARAVDLVE----------------- 316

  Fly   452 NYREQKERRKAQKKHWELSGTKLGNIMGVQRPQDEDDMRF---DKEKDKADYR---KDQKFADHM 510
               |:......:::.||  ..:||          ...::|   |....:..|:   ::::..:.:
Human   317 ---EESGAPGEEQRRWE--EARLG----------AASLKFGARDAASQEPKYQLVLEEEETIEFV 366

  Fly   511 RDQDTGGKSDFS---------RKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQ 566
            |.....|..:.|         :|::|...||.||||..|:|||..|..:.|:||.||||||||||
Human   367 RATQLQGDEEPSAPPTSTQAQQKESIQAVRRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQ 431

  Fly   567 LTQYLHEDGYSKRGM-IGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYM 630
            :.|||.|:||:.:|| |.|||||||||||||.||:.||..:||.:|||:||||||||||||::||
Human   432 IPQYLFEEGYTNKGMKIACTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYM 496

  Fly   631 TDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFA 695
            |||:||||.|.:|:|.|||.:::||||||:|.||:||||::::...|.:||::|.|||||:::|:
Human   497 TDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFS 561

  Fly   696 TFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQEDIEVTCE 760
            |||.:.|.|.||||.||||:.::|....||:|:.|...||:|:|...||:|:|:.|||:||..||
Human   562 TFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQEEIEAACE 626

  Fly   761 VLEERLAEI-DNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVID 824
            :|::|...: .....|.:||||:.||||:||:|||.:..|.||.||||||||||||::|||||:|
Human   627 MLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLD 691

  Fly   825 SGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQ 889
            .|:||.|.||||.||::|.:.|.|:|:||||:|||||...|:.:||||...|:.||...||||||
Human   692 PGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQ 756

  Fly   890 RTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLD 954
            ||:|.|.||||||||:.||:.|.|:||||.:.:|.:|.||:.||||:|.|.|||.||:|||.|:|
Human   757 RTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAELPVD 821

  Fly   955 PPQCQMLIVACRMGCSAEVLIIVSMLSV-PSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQ 1018
            |...:|::.:.:..||.|:|.:.:|||| .|||||||.:...||..|..|..|..|||..||||.
Human   822 PMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYT 886

  Fly  1019 QWRQNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIVRKCICSAYFYQA 1083
            ||.::.|||.||.|:|:..::||:.|:||:||:.::.:..:.:.||..|:..|||.|.:.|||..
Human   887 QWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHT 951

  Fly  1084 ARLKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGP 1148
            |||...| |..::......:||.|:|:  ...|.:::||||::|.||:|:....::..||.|:.|
Human   952 ARLTRSG-YRTVKQQQTVFIHPNSSLF--EQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAP 1013

  Fly  1149 MFFSVKESGRSGREKKKQAAEHLKEMEEQMLKAQHEM 1185
            .::..||          ....|.|:|.:::.|.:.|:
Human  1014 HYYKAKE----------LEDPHAKKMPKKIGKTREEL 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	117/186 (63%)
		DEXDc	551..689	CDD:238005	90/138 (65%)
		HELICc	722..870	CDD:238034	80/148 (54%)
		HA2	932..1014	CDD:214852	41/82 (50%)
		OB_NTP_bind	1048..1148	CDD:285018	33/99 (33%)
DHX16	NP_003578.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..207		37/164 (23%)
		PTZ00121	<148..376	CDD:173412	60/380 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..391		3/19 (16%)
		HrpA	390..1028	CDD:224557	333/650 (51%)
		DEAH box	520..523		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720