DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)G0007 and dhx33

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001093527.3	Gene:	dhx33 / 796505	ZFINID:	ZDB-GENE-131127-77	Length:	680	Species:	Danio rerio

Alignment Length:	640	Identity:	270/640 - (42%)
Similarity:	410/640 - (64%)	Gaps:	17/640 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   527 ISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYSKRGMIGCTQPRRVA 591
            :..|||.||::.||.::::.:|:....:.:||||||||||:.|||:|.|..::|:|..|||||||
Zfish    40 VEAQRRHLPIYQSRTQVISQLRQLHSAVFIGETGSGKTTQIPQYLYEAGIGRQGIIAITQPRRVA 104

  Fly   592 AMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEA 656
            |:|:|.||::|...|||:.|||.:||||.||..|.:|:||||:||||::.||.|..|:.:|:|||
Zfish   105 AISLAGRVAEEKKVQLGKLVGYTVRFEDVTSPETKLKFMTDGMLLREAIGDPLLLRYTVVILDEA 169

  Fly   657 HERSLSTDVLFGLLREIVARRHD-----LKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVM 716
            |||::.||||||:::....||.:     ||::|.|||||...|:.:|...|...:.||..|:.:.
Zfish   170 HERTVHTDVLFGVVKAAQRRRLEQNKIPLKVVVMSATMDVDLFSQYFNKSPVLYLEGRQHPIQIY 234

  Fly   717 FSKNTCEDYVESAVKQALQVHL-TPNEGDMLIFMPGQEDIEV---TCEVLEERLAEIDNAPALSI 777
            ::|....||:::|:....|:|. .|:..|:|:|:.|||:||.   ||..:.:.|.  |.:.::::
Zfish   235 YTKQPQSDYLQAALVSIFQIHQEAPSSHDILVFLTGQEEIEALARTCRDISKHLP--DTSGSMTV 297

  Fly   778 LPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDAL 842
            :|:|:.||...|.::|..:..|.||.:::|||||||:|:.||.||||:|..|.|.:||..|::.|
Zfish   298 VPLYASLPPAQQMRVFLPAPKGSRKVILSTNIAETSITISGIKYVIDTGMVKAKRFNPDSGLEVL 362

  Fly   843 QIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVD 907
            .:..:|:|.|.||:|||||...|..|||||:.:: :.|..:|||||||.|||:.||.|.:|||.|
Zfish   363 AVQRVSKAQAWQRAGRAGREDAGSCYRLYTEDEF-ENLANMTVPEIQRCNLASVVLQLLALGVPD 426

  Fly   908 LLQFHFMDPPPQDNILNSLYQLWILGALDHTG---ALTTLGRQMAEFPLDPPQCQMLIVACRMGC 969
            :|.|.|:..|..:::..::.||.||||:|...   :||.||::||.|||:|...:.|:::....|
Zfish   427 VLNFDFVSKPSPESMRTAVEQLCILGAVDRKDDHVSLTPLGKKMACFPLEPRFSKTLLISPDFSC 491

  Fly   970 SAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNYSSTWCNEHF 1034
            :.|:|.|:|:|||.|:.|.|..|.||...||:||...|.||:|.||:|:.:::.:.:..||.|:|
Zfish   492 TEEILTIISLLSVDSVLYNPPARRDEVISVRKKFISSEGDHITLLNIYRAFKKVSGNKDWCRENF 556

  Fly  1035 IHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIVRKCICSAYFYQAARLKGIGEYVNLRTGM 1099
            ::.:.|..|.|||.||:||..:.||.:.|...|...||:|:....|..||.|:..|.||.|.|..
Zfish   557 VNSRNMGLVGEVRAQLRDICIKMNLKLESSVCDLANVRRCLAHGLFMSAAELQPDGSYVALDTHQ 621

  Fly  1100 PCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSVK 1154
            |..:||:|.|:  ...|..|:::||:.|::.||:....:...||.|..|.:|..|
Zfish   622 PVSIHPSSVLF--QARPVCVLFNELLHTSRCYMRDLCLIQTDWLHEAAPEYFRRK 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	93/190 (49%)
		DEXDc	551..689	CDD:238005	76/142 (54%)
		HELICc	722..870	CDD:238034	60/151 (40%)
		HA2	932..1014	CDD:214852	37/84 (44%)
		OB_NTP_bind	1048..1148	CDD:285018	35/99 (35%)
dhx33	NP_001093527.3	DEXDc	50..234	CDD:214692	88/183 (48%)
		DEXDc	64..207	CDD:238005	76/142 (54%)
		Helicase_C	264..381	CDD:278689	49/118 (42%)
		HA2	451..536	CDD:214852	37/84 (44%)
		OB_NTP_bind	570..670	CDD:285018	36/101 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720