Protein Alignment Prp16 and ythdc2

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: XP_004910524.1
• Gene: ythdc2 / 779469
• XenbaseID: XB-GENE-5881731
• Length: 1457
• Species: Xenopus tropicalis
• Alignment Length: 1005
• Identity: 230/1005 - (22%)
• Similarity: 380/1005 - (37%)
• Gaps: 357/1005 - (35%)

  Fly   433 KDPTSDMALLARKGS---------ALVRNYRE------------QKERRKAQKKHWELSGTKLGN 476
            |.|...:.|..:.||         .|.:|.::            .|||.:...|      |:.||
 Frog   124 KGPNRCLTLKKKNGSEASSSLMSCTLTQNTKKAVCNLIQRFPLTNKERTELLPK------TERGN 182

  Fly   477 IMGVQRPQDEDDMRFDKEKDKADYRKDQKFA-------DHMRDQDTGGKSDFSRKKTISEQRRFL 534
            :..::                |:.|:..|.:       ..:.|:....|.||.|:.        |
 Frog   183 VYAIE----------------AENREIGKTSGCLNGGIPQVPDKRGESKYDFFRQS--------L 223

  Fly   535 PVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYSKRGM---IGCTQPRRVAAMSVA 596
            |||..:::::.:|:.|.|::||||||||||||:.|:: .|...|.|:   |.||||||:||:|||
 Frog   224 PVFEKQEDIIRIIKNNKVVLIVGETGSGKTTQIPQFI-LDNCQKNGLPCRIFCTQPRRLAAISVA 287

  Fly   597 KRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESL-RDPELDSYSAIIMDEAHERS 660
            :||:.|....:|:.|||.||.|...|.:|::.:.|:|:|||..: .|..|.:.:.||:||.|||.
 Frog   288 ERVAAERGEIIGQCVGYQIRLESRVSPKTLLTFCTNGVLLRTLMGGDSTLSAITHIIVDEVHERD 352

  Fly   661 LSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMF-------- 717
            ..:|.|...||:.:.....||||::||.:|.:.|..:||..|...|.||.|.|..||
 Frog   353 RFSDFLLTKLRDAIQEHPTLKLILSSAALDVNLFIRYFGGCPVIYIQGRPFEVKEMFLEDILRST 417

  Fly   718 -----------SKNTCEDYVES------------------------AVKQALQV----------- 736
                       .:..||:..::                        |:|:...:
 Frog   418 GYRNKGMLKYNKEKQCEEKQKTTLTEWYSAKQKNMKPETQRQRSVPAIKEEYDILDDGGDTAFGQ 482

  Fly   737 -------------------------------------HLTPNE---------------------- 742
                                                 ||...|
 Frog   483 MTEKDANCLEPWLIKEIDACLSDIWLYRDKDAFAQLFHLISTENVSVDYRHSETSATPLMVAAGQ 547

  Fly   743 ----------------------------------------------------------------- 742
                                                                             
 Frog   548 GFLSHVEQLISMGANIQSKASNGWMALDWAKHFGQTEVVDLLESYSASLETEDLDENTLVQSDGN 612

  Fly   743 ----------------------------------------GDMLIFMPGQEDI-EVTCEVL--EE 764
                                                    |.:|||:||.::| .:...:|  ::
 Frog   613 DLSIEDRELLKAYHHSFDDEKVDLDLIMHVLFNICQITDTGAILIFLPGYDEIVGLRDRILLDDK 677

  Fly   765 RLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCK 829
            |.|  |||....:..::|.:.:..|.|:.:....|:||.:::|||||||:||:.:::|||||..|
 Frog   678 RFA--DNAQRYHVFMLHSNMQTSDQKKVLKLPPAGIRKIILSTNIAETSITVNDVVFVIDSGKVK 740

  Fly   830 LKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLA 894
            .|.::....:..|::..||:|:|.||.|||||..||..:||:::.:::: :|....||:.|..|.
 Frog   741 EKSFDALNNVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSKLRFQN-MLEFQTPELLRIPLH 804

  Fly   895 NTVLLLKSLGVVDLLQFHFM----DPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDP 955
            ...|..|.|..::.....|:    :|||...:.|::..|..:.|:|:...||.:|..:|:.|::|
 Frog   805 ELCLHTKLLVPINCPVADFLMKAPEPPPALIVRNAVQMLKTIDAMDNWEDLTEIGHHLADLPVEP 869

  Fly   956 PQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGV--REKFQRPE-SDHLTYLNVY 1017
            ...:|::.|..:.|...:|.|...|:....|..|.....:...:  |::|.... |||:..|..:
 Frog   870 HLGKMVLCAVILKCLDPILTIACTLAYRDPFVLPSQASQKRAAMLCRKRFTAGTFSDHMALLRAF 934

  Fly  1018 QQW---RQNNYSSTWCNEHFIHIKAMRKVREVRQQL------------------KDI-MTQQNLS 1060
            |.|   :.:.:...:|.::|:....|..:..:|.||                  :|: :..:|
 Frog   935 QAWQKAKSDGWERAFCEKNFLSQATMEIIIGLRTQLLGQLRASGFVRARGGGDIRDVNINSEN-- 997

  Fly  1061 VISCGIDWDIVRKCICSAYFYQAARLKGIGEYVNL----RTGM--------PCHLHPTSALYGLG 1113
                   |.:|:..:.|            |.|.||    |..|        ....||:|||
 Frog   998 -------WAVVKAALLS------------GMYPNLIHVDRENMVLSGVKEKRVRFHPSSAL---- 1039

  Fly  1114 TTPDYVVYHELIMTAKEYMQCATAVDGYWL 1143
            :.|.|    :.|.:|....:...|:...||
 Frog  1040 SEPQY----KKIPSANCQAEAVQALPTDWL 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	208/876 (24%)
ythdc2	XP_004910524.1	DEXHc_YTHDC2	223..398	CDD:350745	76/175 (43%)
		ANK repeat	535..567	CDD:293786	0/31 (0%)
		ANKYR	<539..>606	CDD:440430	0/66 (0%)
		ANK repeat	569..600	CDD:293786	0/30 (0%)
		OB_NTP_bind	1001..1096	CDD:400182	20/85 (24%)
		YTH	1317..1446	CDD:410979
		R3H_DEXH_helicase	76..134	CDD:100077	3/9 (33%)
		HrpA	222..>1040	CDD:441249	201/854 (24%)