Protein Alignment Prp16 and dhx8

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: XP_002932570.2
• Gene: dhx8 / 733563
• XenbaseID: XB-GENE-6087171
• Length: 1181
• Species: Xenopus tropicalis
• Alignment Length: 1202
• Identity: 467/1202 - (38%)
• Similarity: 670/1202 - (55%)
• Gaps: 167/1202 - (13%)

  Fly    56 KRRAEKERSERLISFKDSEFDDTGGGSSTPQANASGASSEFAFKKPDTKSFEKLRGQLRE-HKDD 119
            |...||..:|    |.||..::......|.:..|..::|:....||..:. |||:..... .:.|
 Frog    54 KSALEKNGAE----FTDSLINNLLRLIQTMRPPAKPSTSKETVIKPKNEK-EKLKELFPALCRAD 113

  Fly   120 TPS-------HTGGVSEKARERLREHIQRDRKRGPVSSTAAEGRDRDRDWDRDRRRDRD---RDR 174
            .||       ....|:..|.:.|...:.:|.:       :::.:|:.:   |.|.|.|:   :.:
 Frog   114 NPSVRTMLDPDDVKVAADALQELEALMPKDER-------SSKHKDKKK---RSRSRSREKGSKHK 168

  Fly   175 DRDRDRRQHRERERDRHRSWDRD-----RGRDRDRDR---SMSERSVH--TPREPGTPGGSSGGI 229
            .:.|.|.|..::.:||:||..|.     |..:...|:   |..|:.|.  .|.||......:|.:
 Frog   169 RKSRSRSQSSKKTKDRYRSRSRSPIKEHRNNEHHSDKYAPSWKEKHVDRPPPEEPAIGDIYNGKV 233

  Fly   230 SNSSWDDEDGEF----GQRKSDWD----MPTPRRHGNKSGDWSVRSGGSR--------------- 271
            ::..   :.|.|    |.||. |:    :...||.|..:....|.|.|.|
 Frog   234 TSIM---QFGCFVQLEGLRKR-WEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGCKTSL 294

  Fly   272 -RNHGRQDDTVRPTPAHRYNQWAHGRKRSGATPWGEDPESLDLWEEEQRRLDREWY----NIDEG 331
             .....||......|..|.|.            .|:..|     |...|..||..:    |..|.
 Frog   295 SMKDVNQDTGEDLNPNRRRNL------------IGDSNE-----EASMRNPDRPSHLSLVNAPEI 342

  Fly   332 YDDENNPFGGPNSEYFRKREEQLEQKRTKRISAQQRQNNRDNELWERNRMLTSGVVT-------- 388
            .||                  .||:||..:||        |.|.||..:|:.:.|::
 Frog   343 EDD------------------TLERKRLTKIS--------DPEKWEIKQMIAANVLSKEEFPDFD 381

  Fly   389 ----LISVNDDFDEEALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMALLARKGSAL 449
                ::...||.::|.|| :.|:...  ||||.|....:....|:..||:|...::..|...|||
 Frog   382 EETGILPKVDDEEDEDLE-IELVEEE--PPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSAL 443

  Fly   450 VRNYREQKE-RRKAQ--------KKHW-----ELSGTKL-GNIMGV-QRPQDEDDMRFDKEKDKA 498
            .:..||.|: :|:|:        .|||     :..|.:: .|:.|: ..|.|..:.
 Frog   444 AKERREMKQAQREAEMDSIPMGLNKHWVDPLPDADGRQIAANMRGIGMMPNDIPEW--------- 499

  Fly   499 DYRKDQKFADHMRDQDTGGKSDFSRKKTIS--EQRRFLPVFASRQELLNVIRENSVIIIVGETGS 561
               |...|.        |.|:.:.:|..:|  |||..||::..:::|:..:.:|.::|::|||||
 Frog   500 ---KKHAFG--------GNKASYGKKTQMSIVEQRESLPIYKLKEQLVQAVHDNQILIVIGETGS 553

  Fly   562 GKTTQLTQYLHEDGYSKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTV 626
            |||||:||||.|.||:.||.|||||||||||||||||||:|....||::|||.||||||||..||
 Frog   554 GKTTQITQYLAEAGYTTRGKIGCTQPRRVAAMSVAKRVSEEYGCCLGQEVGYTIRFEDCTSPETV 618

  Fly   627 IKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDS 691
            |||||||:||||.|.||:|..|:.|::||||||::.||||||||::.|.:|.|:||||||||:|:
 Frog   619 IKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRPDMKLIVTSATLDA 683

  Fly   692 SKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQEDIE 756
            .||:.:|...|.|||||||:||:::::|....||:::::...:|:|||...||:|:|:.|||:|:
 Frog   684 VKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEID 748

  Fly   757 VTCEVLEERLAEI-DNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGII 820
            ..||:|.||:..: .:.|.|.|||:||.|||::|.:||..:..|.||.|:||||||||||:|||.
 Frog   749 TACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIY 813

  Fly   821 YVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTV 885
            ||:|.|:.|.||||.:.|:|.|.:.|||||.|.||:|||||||||:.|||||:|.|:||:|...|
 Frog   814 YVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNV 878

  Fly   886 PEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAE 950
            |||||||||:|||.||::|:.|||.|.|||.||.:.::.::.||:.|||||..|.||.|||:|||
 Frog   879 PEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAE 943

  Fly   951 FPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLN 1015
            |||:|..|:|||::..:|||.|:|.|||||||.::|||||.::..||..:.||.:.|.||||.|.
 Frog   944 FPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLA 1008

  Fly  1016 VYQQWRQNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIVRKCICSAYF 1080
            ||..|:.|.:|:.||.|:||..:::|:.:::|:|:..||.:..|.|:|||.....|:|.|||.:|
 Frog  1009 VYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKATVRVQKAICSGFF 1073

  Fly  1081 YQAARLKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAE 1145
            ..||:......|..|......::||:|||:  ...|::||||||::|.||||:..|.:|..||.|
 Frog  1074 RNAAKKDPQEGYRTLIDQQVVYIHPSSALF--NRQPEWVVYHELVLTTKEYMREVTTIDPRWLVE 1136

  Fly  1146 LGPMFFSVKESGRSGREKKKQAAEHLKEMEEQ 1177
            ..|.||.|.:..:..::||:|..|.|....|:
 Frog  1137 FAPAFFKVSDPTKLSKQKKQQRLEPLYNRYEE 1168

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	332/614 (54%)
dhx8	XP_002932570.2	GH2-like_DHX8	12..79	CDD:409668	7/28 (25%)
		S1_DHX8_helicase	226..304	CDD:240189	16/81 (20%)
		HrpA	517..>1148	CDD:441249	340/632 (54%)