Protein Alignment Prp16 and Dhx30

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: NP_001239612.1
• Gene: Dhx30 / 72831
• MGIID: 1920081
• Length: 1223
• Species: Mus musculus
• Alignment Length: 1142
• Identity: 278/1142 - (24%)
• Similarity: 451/1142 - (39%)
• Gaps: 261/1142 - (22%)

  Fly   205 DRSMSERSVHTPREPGTPGGSSGGISNSSWD---------------------------------- 235
            |.:.....|.:...|..||...|.:.|:|.|
Mouse    44 DGTQEAAEVESEVAPSEPGEGDGSMVNASRDLLKEFPQPKNLLNSVIGRALGISHAKDKLVYVHT 108

  Fly   236 ------------------DEDGEFGQRKSD---------------WDMPTPRRHGNKSGDWSV-- 265
                              :.:| :|.:|.|               |.:..||.....:..:.|
Mouse   109 NGPKKKKVTLHIKWPKSVEVEG-YGSKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRVLA 172

  Fly   266 -RSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRSGATPWGEDPESLDLWEEEQRRLDREWYNID 329
             |.|....:..|.:.|:.||...:.|.       ....|.|....|..|..||:
Mouse   173 DRFGSPADSWWRPEPTMPPTSWRQLNP-------ENIRPGGPAGLSRSLGREEE----------- 219

  Fly   330 EGYDDENNPFGGPNSEYFRKREEQLEQKR---TKRISAQQRQNNRDNELWERNRMLTSGVVTLIS 391
               :||               ||:||:..   |:.:|..|:.::        |.:..|...:...
Mouse   220 ---EDE---------------EEELEEGTIDVTEFLSMTQQDSH--------NPLRDSRGGSFEM 258

  Fly   392 VNDDFDEEALERVHL---LVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMALLARKGSALVRNY 453
            .:||....||.:..|   |:..:|.................|..|...:.:.||.......|...
Mouse   259 TDDDSAIRALTQFPLPKNLLAKVIQIATSSSTAKNLMQFHTVGTKTKLATLTLLWPCPMTFVAKG 323

  Fly   454 REQKERRKAQKKHWELSGTKLGNIMGVQRPQDE--------DDMRFDKEKDKAD---------YR 501
            |.:.|   |:.|...|:..||.::..|.|..:.        ..:|...|..:..         .|
Mouse   324 RRKAE---AENKAAALACKKLKSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEPILR 385

  Fly   502 KDQKFADH-----------MRDQ---------DTGGKSD-------------------------F 521
            |.:.|..|           :|.|         |:|..||                         :
Mouse   386 KIEAFLSHYPVDSSWISPELRLQSDDILPLGKDSGPLSDPITGKPYMPLSEAEEVRLSQSLLELW 450

  Fly   522 SRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHE----DGYSKRGMI 582
            .|:..|.::...|||...|..:|:.|.::.|::|.|:||.||||::.|.|.|    :|...|..:
Mouse   451 RRRGPIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNV 515

  Fly   583 GCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSER-TVIKYMTDGILLRESLRDPELD 646
            ..|||||::|:|||:|||.|:...|..:||:.:|.|.....| ..:.:.|.|||||:...:|.|:
Mouse   516 IITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLE 580

  Fly   647 SYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTF 711
            ..|.:|:||.|||.::||.|..||:.:......|:|::.|||.|:.:|:.:||..|...:||..:
Mouse   581 GVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMY 645

  Fly   712 PV------DVMF---------------SKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQEDI 755
            ||      |::.               |::.|...::......|.:......|.:|.|:||.::|
Mouse   646 PVKEHYLEDILAKLGKHQYPHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEI 710

  Fly   756 EVTCEVLEERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGII 820
            :...:.|:|.|...::  ...|||::|.:|...|..|||:...|:||.|:||||||||:||:.|:
Mouse   711 KGVQQRLQEALGMHES--KYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIV 773

  Fly   821 YVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTV 885
            :|:|||..|.:.|:.:..:..|:...:|:||..||.|||||...|.||.|: .|...::::...|
Mouse   774 HVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLF-PRSRLEKMVPFQV 837

  Fly   886 PEIQRTNLANTVLLLK----SLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGR 946
            |||.||.|.|.||..|    ....|:.|. ..:|.|....:..::..|..:|.||....|||||:
Mouse   838 PEILRTPLENLVLQAKIHMPEKTAVEFLS-KAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQ 901

  Fly   947 QMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPE-SDH 1010
            ::|....||...:.:::|....|...:|::||.|:........:.|. |.|.|:....... |||
Mouse   902 RLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRA-EVDKVKALLSHDSGSDH 965

  Fly  1011 LTYLNVYQ------QWRQNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNL--SVISCGID 1067
            |.::....      :|:.......:..|:.::..::|.:..:.:|..:.:.:..|  ....|.:.
Mouse   966 LAFVRAVAGWEEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLP 1030

  Fly  1068 WDIVRKCICSAYFYQAARLKGI---GEYVNL---------RTGMPCHLHPTSALYGLGTTPDYVV 1120
                 ...|:.|..:...:||:   |.|.||         |.|   ...|.|..|  .|....::
Mouse  1031 -----SAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQG---KFKPNSVTY--RTKSGNIL 1085

  Fly  1121 YHELIMTAKEYMQCATAVDGYWLAELGPMFFSVKESG 1157
            .|:..:..:     ||.:...||.    .|.:||.:|
Mouse  1086 LHKSTINRE-----ATRLRSRWLT----YFMAVKSNG 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	198/664 (30%)
Dhx30	NP_001239612.1	HrpA	455..>987	CDD:441249	175/536 (33%)
		OB_NTP_bind	1044..1131	CDD:400182	21/84 (25%)