Protein Alignment Prp16 and Dhx16

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: XP_006524936.1
• Gene: Dhx16 / 69192
• MGIID: 1916442
• Length: 1049
• Species: Mus musculus
• Alignment Length: 1201
• Identity: 435/1201 - (36%)
• Similarity: 635/1201 - (52%)
• Gaps: 209/1201 - (17%)

  Fly    12 LEGTAGQETRGGLVIRKPKDAGAGGGGG----------FKVPQGSMLGLDKLAAKRRA----EKE 62
            |.|||.:.......:::.:|......||          .|||:.:::.....||:|.|    ||.
Mouse    30 LIGTAQRCASAEEFVQRLRDTDTLDLGGPARDFALKLWSKVPRKAVVEKPARAAEREARALLEKN 94

  Fly    63 RSERLISFKDSEFDDTGGGSSTPQANASGASSEFAFKKPDTKSFEKLRGQLR-EHKDDTPSHTGG 126
            ||.:|:  :|||..:...||       :|:|.:   ||      .|.|..|| :|::|.......
Mouse    95 RSYKLL--EDSESGEEAVGS-------NGSSLQ---KK------RKRRKHLRKKHQEDEEDEEEE 141

  Fly   127 VSEKARERLREHIQRDRKRGPVSSTAAEGRDRDRDWDRDRRRDRDRDRDRDRDRRQHRERERDRH 191
            |||..:          ||.|...|...|....:.:|:|           .:|:|.|..| |||..
Mouse   142 VSESGK----------RKAGGSKSPTEEKPASEDEWER-----------TERERLQDLE-ERDAF 184

  Fly   192 RSWDRDRGRDRDRDRSMSERSVHTPREPGTPGGSSGGISNSSWDDEDGEFGQRKSDWDMPTPRRH 256
            .  :|.|.||:||.|::.|||                 ...::::........:.|.....|...
Mouse   185 A--ERVRQRDKDRTRNVLERS-----------------DKKAYEEAQKRLKMAEEDRKAMVPELR 230

  Fly   257 GNKSGDWSVRSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRSGATPWGEDPESLDLWEEEQRRL 321
            ..           |||.:                                      |.:.|:.:|
Mouse   231 KK-----------SRREY--------------------------------------LAKREREKL 246

  Fly   322 DREWYNIDEGYDDENNPFGGPNSEYFRKREEQLEQKRTKR-ISAQQRQNNRDNELWERNRMLTSG 385
            :    :::....||...||  :.|..|....:|:.||..| ::.:.|......:|
Mouse   247 E----DLEAELADEEVLFG--DVELSRHERRELKYKRRVRDLAREYRAAGEQEKL---------- 295

  Fly   386 VVTLISVNDDFDEEALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMALLARKGSALV 450
                         ||..|.|:      |....|      ||...|.:.:
Mouse   296 -------------EATNRYHM------PKETRG------QPARTVDIVE---------------- 319

  Fly   451 RNYREQKERRKAQKKHWELSGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRKDQKFADHMRDQDT 515
                |:......:::.||.:.....::....|.....:.::....::.:..:..:.|....|::.
Mouse   320 ----EESGAPGEEQRRWEEAQLGAASLKFGARDAAAQEAKYQLVLEEDETIEFVRAAQLQGDEEP 380

  Fly   516 GG---KSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYS 577
            .|   .:...:|::|...||.||||..|:|||..|..:.|:||.||||||||||:.|||.|:||:
Mouse   381 SGPPLSAQAQQKESIQAVRRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYT 445

  Fly   578 KRGM-IGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLR 641
            |:|| |.|||||||||||||.||:.||..:||.:|||:||||||||||||::|||||:||||.|.
Mouse   446 KKGMKIACTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLS 510

  Fly   642 DPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTI 706
            :|:|.|||.:::||||||:|.||:||||::::...|.:||::|.|||:|:::|:.||.:.|.|.|
Mouse   511 EPDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATLDTARFSAFFDDAPVFRI 575

  Fly   707 PGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQ-----EDIEVTCEVLEERL 766
            |||.||||:.::|....||:|:.|...||:|:|...||:|:|:.||     |:||..||:|::|.
Mouse   576 PGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPGDILVFLTGQVSAVVEEIEAACEMLQDRC 640

  Fly   767 AEI-DNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKL 830
            ..: .....|.:||||:.||||:||:|||.:..|.||.||||||||||||::|||||:|.|:||.
Mouse   641 RRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQ 705

  Fly   831 KVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLAN 895
            |.||||.||::|.:.|.|:|:||||:|||||...|:.:||||...|:.||...||||||||:|.|
Mouse   706 KSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGN 770

  Fly   896 TVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQM 960
            .||||||||:.||:.|.|:||||.:.:|.:|.||:.||||:|.|.|||.||:|||.|:||...:|
Mouse   771 VVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKM 835

  Fly   961 LIVACRMGCSAEVLIIVSMLSV-PSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNN 1024
            ::.:.:..||.|:|.:.:|||| .|||||||.:...||..|..|..|..|||..||||.||.::.
Mouse   836 ILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESG 900

  Fly  1025 YSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIVRKCICSAYFYQAARLKGI 1089
            |||.||.|:|:..::||:.|:||:||:.::.:..:.:.||..|:..|||.|.|.|||..|||...
Mouse   901 YSSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGLTSCQGDYVRVRKAITSGYFYHTARLTRS 965

  Fly  1090 GEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSVK 1154
            | |..::......:||.|:|:  ...|.:::||||::|.||:|:....::..||.|:.|.::..|
Mouse   966 G-YRTVKQQQTVFIHPNSSLF--EQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAK 1027

  Fly  1155 ESGRSGREKKKQAAEHLKEMEEQMLKAQHEM 1185
            |          ....|.|:|.:::.|.:.|:
Mouse  1028 E----------LEDPHAKKMPKKVGKTREEL 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	326/621 (52%)
Dhx16	XP_006524936.1	PTZ00121	<147..>410	CDD:173412	69/413 (17%)
		HrpA	401..>1033	CDD:441249	329/644 (51%)