DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and Dhx40

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_080467.3	Gene:	Dhx40 / 67487	MGIID:	1914737	Length:	779	Species:	Mus musculus

Alignment Length:	752	Identity:	280/752 - (37%)
Similarity:	434/752 - (57%)	Gaps:	86/752 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   519 SDFSRKKTISEQRRFLPVF---ASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYSKRG 580
            :|...|...|::....|.|   ..|::|:..:|:||.:|:.|.|||||||||.:||:|.|:|:.|
Mouse    35 ADREEKGCTSQEGGTTPTFPIQKQRKKLIQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHG 99

  Fly   581 MIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPEL 645
            |||.||||:|||:|||:||::||...||..|||.:||:||:|:.|.|||||||.||:..|.||.|
Mouse   100 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNL 164

  Fly   646 DSYSAIIMDEAHERSLSTDVLFGLLREIVA-----RRHDLKLIVTSATMDSSKFATFFGNVPTFT 705
            ..:|.||:||||||:|:||:|||||:::..     |:..||::|.||||:.:|.:.||||.|.|.
Mouse   165 SKFSVIILDEAHERTLTTDILFGLLKKLFQDKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFD 229

  Fly   706 IPGRTFPVDVMF--------SKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQEDIEVTCEVL 762
            ||||.:||...|        .:||.  |:::.||..:.:||....||:|:|:.||.:||.:||:|
Mouse   230 IPGRLYPVREKFCNLIGPRDRENTA--YIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELL 292

  Fly   763 EERLAEID--------NAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGI 819
            .:....:|        ....|.|||.|..:.:|.|.:||.....|:||||::|||:.||||:|||
Mouse   293 FQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGI 357

  Fly   820 IYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALT 884
            .||:|.|:.|...:|||:|:|.|::.|||::.|.|||||||||..|:.:|:|::..:...:....
Mouse   358 RYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTASGKCFRIYSKEFWSQCMPDHV 422

  Fly   885 VPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMA 949
            :|||:||:|.:.||.||.|.:.|:::|.::|||.:..||.:|.||:...|:|.:|.:|.||..|.
Mouse   423 IPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMV 487

  Fly   950 EFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPE------- 1007
            ||||.|.....:|.|..:.|...:|.|.:||||.::|.||...|.:    :|..||..
Mouse   488 EFPLPPHLTCAVIRAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQ----KEAEQRHRELAAKAG 548

  Fly  1008 --SDHLTYLNVYQQWRQNNYSSTWCNEHFIHIKAMRKVREVRQQLKDI---MTQQNLSVISCGID 1067
              :|..|...:::|.:.:...::||.:|:||.:.:.....|..||:::   :.||:        |
Mouse   549 GFNDFATLAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQS--------D 605

  Fly  1068 W----------DIVRKCICSAYFYQAARLKGIGEYVNLRT-------GMPCHLHPTSALYGLGTT 1115
            :          :::|:|:|:.||...|| :.:|     ||       |.|.|:||:|||:...|.
Mouse   606 FPRETFEGPKHEVLRRCLCAGYFKNVAR-RSVG-----RTFCTMDGRGSPVHIHPSSALHEQETK 664

  Fly  1116 PDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSV----------KESGRSGREK--KKQAA 1168
            .:::::||:::|.|.|.:....:...|:.:|.|....:          :|.....|.|  .|:..
Mouse   665 LEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHELNAHDLSSVARREMREDARRKWTNKENV 729

  Fly  1169 EHLKE-MEEQMLKAQHEMEERKQQAAEREEQLATKQE 1204
            :.||: :.:::||......:.|..:..|...|..||:
Mouse   730 KQLKDGISKEVLKKMQRRNDDKSISDARARFLERKQQ 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	103/193 (53%)
		DEXDc	551..689	CDD:238005	82/142 (58%)
		HELICc	722..870	CDD:238034	66/155 (43%)
		HA2	932..1014	CDD:214852	30/90 (33%)
		OB_NTP_bind	1048..1148	CDD:285018	31/119 (26%)
Dhx40	NP_080467.3	OB_NTP_bind	591..699	CDD:285018	32/121 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		4/17 (24%)
		DEXDc	48..236	CDD:214692	101/187 (54%)
		DEXDc	78..213	CDD:238005	79/134 (59%)
		DEAH box	173..176		2/2 (100%)
		HELICc	312..399	CDD:197757	45/86 (52%)
		HA2	469..557	CDD:214852	30/91 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820