Protein Alignment l(1)G0007 and YTHDC2

DIOPT Version :9

• Sequence 1: NP_572947.1
• Gene: l(1)G0007 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: XP_011541883.1
• Gene: YTHDC2 / 64848
• HGNCID: 24721
• Length: 1439
• Species: Homo sapiens
• Alignment Length: 1103
• Identity: 248/1103 - (22%)
• Similarity: 409/1103 - (37%)
• Gaps: 402/1103 - (36%)

  Fly   457 KERRKAQKKHWELSGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRKDQKFADHMRDQDTG----- 516
            |||.:...|      |:.||:..|:                |:.|:..|.:..:   :.|
Human   139 KERTELLPK------TERGNVFAVE----------------AENREMSKTSGRL---NNGIPQIP 178

  Fly   517 ---GKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYSK 578
               |:|:|      ...|:.||||..::|::.:|:||.|::||||||||||||:.|:|.:|.: |
Human   179 VKRGESEF------DSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCF-K 236

  Fly   579 RGM---IGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESL 640
            .|:   |.||||||:||::||:||:.|...::|:.:||.||.|...|.:|::.:.|:|:|||..:
Human   237 NGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLM 301

  Fly   641 R-DPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTF 704
            . |..|.:.:.:|:||.|||...:|.|...||:::.:...||||::||.:|.:.|..:||:.|..
Human   302 AGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVI 366

  Fly   705 TIPGRTFPVDVMF---------------------------------------------------- 717
            .|.||.|.|..||
Human   367 YIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEEKQQTTLTEWYSAQENSFKPESQRQRT 431

  Fly   718 --------------------------------------------------------------SKN 720
                                                                          ::|
Human   432 VLNVTDEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDIDAFAQVFHLILTEN 496

  Fly   721 TCEDY---------------------VESAVKQALQVHLTPNEGDM------------------- 745
            ...||                     ||..:.....||...:.|.|
Human   497 VSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLES 561

  Fly   746 ----------------------------------------------------------------L 746
                                                                            |
Human   562 YSATLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAVL 626

  Fly   747 IFMPGQEDI-EVTCEVL--EERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATN 808
            ||:||.::| .:...:|  ::|.|  |:.....:..::|.:.:..|.|:.:....|:||.:::||
Human   627 IFLPGYDEIVGLRDRILFDDKRFA--DSTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTN 689

  Fly   809 IAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQ 873
            |||||:||:.:::|||||..|.|.::....:..|::..||:|:|.||.|||||..||..:||:::
Human   690 IAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSR 754

  Fly   874 RQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFM----DPPPQDNILNSLYQLWILGA 934
            .:::: :|....||:.|..|....|..|.|..|:.....|:    :|||...:.|::..|..:.|
Human   755 LRFQN-MLEFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDA 818

  Fly   935 LDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGV 999
            :|....||.||..:|:.|::|...:|::.|..:.|...:|.|...|:....|..|.....:...:
Human   819 MDTWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAM 883

  Fly  1000 --REKFQRPE-SDHLTYLNVYQQW---RQNNYSSTWCNEHFIHIKAMRKVREVRQQL-------- 1050
              |::|.... |||:..|..:|.|   |.:.:...:|.::|:....|..:..:|.||
Human   884 LCRKRFTAGAFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASG 948

  Fly  1051 ----------KDIMTQQNLSVISCGIDWDIVRKCICSAYFYQAARLKGIGEYVNL---------R 1096
                      :|:.|...        :|.:|:..:.:            |.|.||         .
Human   949 FVRARGGGDIRDVNTNSE--------NWAVVKAALVA------------GMYPNLVHVDRENLVL 993

  Fly  1097 TG---MPCHLHPTS------------------ALYGLGTTPDYVVYHELIMTAK-EYMQCATAVD 1139
            ||   .....||.|                  |:..|.|  |:::|.|:....: ..::|.:||.
Human   994 TGPKEKKVRFHPASVLSQPQYKKIPPANGQAAAIKALPT--DWLIYDEMTRAHRIANIRCCSAVT 1056

  Fly  1140 GYWL------AELG------PMFFSV----KESGRSGREKKKQAAEHLKEMEE------------ 1176
            ...:      |.|.      |..|.|    .:|..|..|.|..|.....:::|
Human  1057 PVTILVFCGPARLASNALQEPSSFRVDGIPNDSSDSEMEDKTTANLAALKLDEWLHFTLEPEAAS 1121

  Fly  1177 ---QMLKAQHEMEERKQQAAER-------------------EEQLATKQEIATPGNATPRRTP 1217
               |:.:..|.:..|:.:|..:                   |||.|..|:   |.....|..|
Human  1122 LLLQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQQ---PSGIGQRPRP 1181

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	82/189 (43%)
		DEXDc	551..689	CDD:238005	63/141 (45%)
		HELICc	722..870	CDD:238034	54/254 (21%)
		HA2	932..1014	CDD:214852	22/84 (26%)
		OB_NTP_bind	1048..1148	CDD:285018	26/160 (16%)
YTHDC2	XP_011541883.1	R3H_DEXH_helicase	46..104	CDD:100077
		HrpA	189..>1016	CDD:224557	201/850 (24%)
		DEXHc_YTHDC2	193..368	CDD:350745	76/175 (43%)
		ANK repeat	505..537	CDD:293786	4/31 (13%)
		ANK repeat	539..564	CDD:293786	2/24 (8%)
		OB_NTP_bind	971..1066	CDD:369483	19/108 (18%)
		YTH	1288..1404	CDD:367840

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810