Protein Alignment Prp16 and Dhx38

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: NP_848467.1
• Gene: Dhx38 / 64340
• MGIID: 1927617
• Length: 1228
• Species: Mus musculus
• Alignment Length: 1262
• Identity: 770/1262 - (61%)
• Similarity: 954/1262 - (75%)
• Gaps: 83/1262 - (6%)

  Fly     5 DESGVHRLEGTAGQETRGGLVIRKPKDAGAGGGGGFK--VPQGSMLGLDKLAAKRRAEKE----- 62
            :::.:||||||:.....|||:. |.|.| |.....||  .|:.|:||||.||:.:|.|:|
Mouse     6 EDTSIHRLEGTSLDSQVGGLIC-KTKSA-ANEQHVFKAPAPRPSLLGLDLLASLKRREREEKDDG 68

  Fly    63 ---RSERLISFKDSEFDDTGGGSSTPQANASGASSEFAFKKPDTKSFEKLRGQLREHKDDTPSHT 124
               :..|:.|:||.|      .|...|.:|...|.:.|     .:|..:.| ..|..:.:||||.
Mouse    69 EDKKKSRVSSYKDWE------ESKDDQKDAEEESEDQA-----GRSSRRDR-HYRSARVETPSHP 121

  Fly   125 GGVSEKARERLREHIQRDRKRGPVSSTAAEGRDRDRDWDRDRRRDRDRDRDRDRDRRQHRERERD 189
            |||||:..||.|:. :|||:...|.:::.|.:||.::      |.||||.||.|||...|:|.|.
Mouse   122 GGVSEEFWERSRQR-ERDRREHGVYASSKEEKDRKKE------RSRDRDYDRKRDRADERDRSRH 179

  Fly   190 RHRSWDRDRGRDRDRDRSMSERSVHTPREPGTPGGSSGGISNSSWDDEDGEFG-QRKSDWDMPTP 253
            ..|| |||.|.:|...|:..|...|.|::..||       |.|:|:::|..:| .|:|.|:.|:|
Mouse   180 SSRS-DRDGGSERSSRRNEPESPRHRPKDAATP-------SRSAWEEDDSGYGSSRRSQWETPSP 236

  Fly   254 ----------RRHGNKSGDWSVRSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRSGATPW---- 304
                      .|...:..|.|:||..|       |||..|||:::||:||..|:..|:||.
Mouse   237 TPSYRDSERGHRPSTRDRDRSIRSKSS-------DDTPLPTPSYKYNEWADDRRHLGSTPRLSRG 294

  Fly   305 ------GEDPESLDL------WEEEQRRLDREWYNIDEGYDDENNPFGGPNSEYFRKREEQLEQK 357
                  ||:..:.|.      ||::||:.||:||.:|||||:.:||....:.:|.|:||:.|.::
Mouse   295 RGRREDGEEGIAFDTEEERQQWEDDQRQADRDWYMMDEGYDEFHNPLAYSSEDYVRRREQHLHKQ 359

  Fly   358 RTKRISAQQRQNNRDNELWERNRMLTSGVVTLISVNDDFDEEALERVHLLVHHIIPPFLDGRIVF 422
            :.||||||:||.|.|||.||.|||||||||..:.|::||:|:...:|||:||:::||||||||||
Mouse   360 KQKRISAQRRQINEDNERWETNRMLTSGVVHRLEVDEDFEEDNAAKVHLMVHNLVPPFLDGRIVF 424

  Fly   423 TKQPEPVVPVKDPTSDMALLARKGSALVRNYREQKERRKAQKKHWELSGTKLGNIMGVQRPQDED 487
            |||||||:||||.|||:|::|||||..||.:||||||||||.|||||:|||||:||||::.::.|
Mouse   425 TKQPEPVIPVKDATSDLAIIARKGSQTVRKHREQKERRKAQHKHWELAGTKLGDIMGVKKEEEPD 489

  Fly   488 DMRFDKEKDKADYRKDQKFADHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSV 552
              :...|..|.|||.:|||||||::: :...|:|::||:|.|||::||:||.:||||.:||:||:
Mouse   490 --KAMTEDGKVDYRTEQKFADHMKEK-SEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSI 551

  Fly   553 IIIVGETGSGKTTQLTQYLHEDGYSKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRF 617
            :|:|||||||||||||||||||||:..|||||||||||||||||||||:||...|||:|||||||
Mouse   552 VIVVGETGSGKTTQLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIRF 616

  Fly   618 EDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKL 682
            ||||||.|:|||||||||||||||:.:||.|||:||||||||||:||||||||||:||||.||||
Mouse   617 EDCTSENTLIKYMTDGILLRESLREADLDHYSAVIMDEAHERSLNTDVLFGLLREVVARRSDLKL 681

  Fly   683 IVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEGDMLI 747
            ||||||||:.|||.||||||.|.|||||||||::|||...|||||:||||:|||||:...||:||
Mouse   682 IVTSATMDAEKFAAFFGNVPIFHIPGRTFPVDILFSKTPQEDYVEAAVKQSLQVHLSGAPGDILI 746

  Fly   748 FMPGQEDIEVTCEVLEERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAET 812
            |||||||||||.:.:.|.|.|::|||||::||||||||||||||||||:.||:|||:||||||||
Mouse   747 FMPGQEDIEVTSDQIVEHLEELENAPALAVLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAET 811

  Fly   813 SLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYK 877
            |||||||::|||||||||||:|||||||||||||||||||||||||||||||||.:|||||..||
Mouse   812 SLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGRAGRTGPGQCFRLYTQSAYK 876

  Fly   878 DELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALT 942
            :|||..||||||||||||.|||||||||.||||||||||||:||:|||:||||||||||:||.||
Mouse   877 NELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQFHFMDPPPEDNMLNSMYQLWILGALDNTGGLT 941

  Fly   943 TLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPE 1007
            :.||.|.||||||...:||||:|.||||:|:|:||||||||:|||||||||:|:|.:||||..||
Mouse   942 STGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIVSMLSVPAIFYRPKGREEESDQIREKFAVPE 1006

  Fly  1008 SDHLTYLNVYQQWRQNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIVR 1072
            ||||||||||.||:.||||:.|||:||||.||||||||||.||||||.||.:|:.|||.||||||
Mouse  1007 SDHLTYLNVYLQWKNNNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSLASCGTDWDIVR 1071

  Fly  1073 KCICSAYFYQAARLKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATA 1137
            ||||:|||:|||:|||||||||:||||||||||||:|:|:|.||||:|||||:||.||||||.||
Mouse  1072 KCICAAYFHQAAKLKGIGEYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHELVMTTKEYMQCVTA 1136

  Fly  1138 VDGYWLAELGPMFFSVKESGRSGREKKKQAAEHLKEMEEQMLKAQHEMEERKQQAAEREEQLATK 1202
            |||.|||||||||:|||::|:|.:|.:::|.|....|||:|..|:.::..|:|:..:|....:.:
Mouse  1137 VDGEWLAELGPMFYSVKQAGKSRQENRRRAKEEASAMEEEMALAEEQLRARRQEQEKRSPLGSVR 1201

  Fly  1203 Q-EIATPGN------ATPRRTPARIGL 1222
            . :|.|||.      .||||||||.||
Mouse  1202 STKIYTPGRKEQGEPMTPRRTPARFGL 1228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	490/613 (80%)
Dhx38	NP_848467.1	HrpA	533..>1147	CDD:441249	490/613 (80%)