DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and Dhx38

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_848467.1	Gene:	Dhx38 / 64340	MGIID:	1927617	Length:	1228	Species:	Mus musculus

Alignment Length:	1262	Identity:	770/1262 - (61%)
Similarity:	954/1262 - (75%)	Gaps:	83/1262 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DESGVHRLEGTAGQETRGGLVIRKPKDAGAGGGGGFK--VPQGSMLGLDKLAAKRRAEKE----- 62
            :::.:||||||:.....|||:. |.|.| |.....||  .|:.|:||||.||:.:|.|:|
Mouse     6 EDTSIHRLEGTSLDSQVGGLIC-KTKSA-ANEQHVFKAPAPRPSLLGLDLLASLKRREREEKDDG 68

  Fly    63 ---RSERLISFKDSEFDDTGGGSSTPQANASGASSEFAFKKPDTKSFEKLRGQLREHKDDTPSHT 124
               :..|:.|:||.|      .|...|.:|...|.:.|     .:|..:.| ..|..:.:||||.
Mouse    69 EDKKKSRVSSYKDWE------ESKDDQKDAEEESEDQA-----GRSSRRDR-HYRSARVETPSHP 121

  Fly   125 GGVSEKARERLREHIQRDRKRGPVSSTAAEGRDRDRDWDRDRRRDRDRDRDRDRDRRQHRERERD 189
            |||||:..||.|:. :|||:...|.:::.|.:||.::      |.||||.||.|||...|:|.|.
Mouse   122 GGVSEEFWERSRQR-ERDRREHGVYASSKEEKDRKKE------RSRDRDYDRKRDRADERDRSRH 179

  Fly   190 RHRSWDRDRGRDRDRDRSMSERSVHTPREPGTPGGSSGGISNSSWDDEDGEFG-QRKSDWDMPTP 253
            ..|| |||.|.:|...|:..|...|.|::..||       |.|:|:::|..:| .|:|.|:.|:|
Mouse   180 SSRS-DRDGGSERSSRRNEPESPRHRPKDAATP-------SRSAWEEDDSGYGSSRRSQWETPSP 236

  Fly   254 ----------RRHGNKSGDWSVRSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRSGATPW---- 304
                      .|...:..|.|:||..|       |||..|||:::||:||..|:..|:||.
Mouse   237 TPSYRDSERGHRPSTRDRDRSIRSKSS-------DDTPLPTPSYKYNEWADDRRHLGSTPRLSRG 294

  Fly   305 ------GEDPESLDL------WEEEQRRLDREWYNIDEGYDDENNPFGGPNSEYFRKREEQLEQK 357
                  ||:..:.|.      ||::||:.||:||.:|||||:.:||....:.:|.|:||:.|.::
Mouse   295 RGRREDGEEGIAFDTEEERQQWEDDQRQADRDWYMMDEGYDEFHNPLAYSSEDYVRRREQHLHKQ 359

  Fly   358 RTKRISAQQRQNNRDNELWERNRMLTSGVVTLISVNDDFDEEALERVHLLVHHIIPPFLDGRIVF 422
            :.||||||:||.|.|||.||.|||||||||..:.|::||:|:...:|||:||:::||||||||||
Mouse   360 KQKRISAQRRQINEDNERWETNRMLTSGVVHRLEVDEDFEEDNAAKVHLMVHNLVPPFLDGRIVF 424

  Fly   423 TKQPEPVVPVKDPTSDMALLARKGSALVRNYREQKERRKAQKKHWELSGTKLGNIMGVQRPQDED 487
            |||||||:||||.|||:|::|||||..||.:||||||||||.|||||:|||||:||||::.::.|
Mouse   425 TKQPEPVIPVKDATSDLAIIARKGSQTVRKHREQKERRKAQHKHWELAGTKLGDIMGVKKEEEPD 489

  Fly   488 DMRFDKEKDKADYRKDQKFADHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSV 552
              :...|..|.|||.:|||||||::: :...|:|::||:|.|||::||:||.:||||.:||:||:
Mouse   490 --KAMTEDGKVDYRTEQKFADHMKEK-SEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSI 551

  Fly   553 IIIVGETGSGKTTQLTQYLHEDGYSKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRF 617
            :|:|||||||||||||||||||||:..|||||||||||||||||||||:||...|||:|||||||
Mouse   552 VIVVGETGSGKTTQLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIRF 616

  Fly   618 EDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKL 682
            ||||||.|:|||||||||||||||:.:||.|||:||||||||||:||||||||||:||||.||||
Mouse   617 EDCTSENTLIKYMTDGILLRESLREADLDHYSAVIMDEAHERSLNTDVLFGLLREVVARRSDLKL 681

  Fly   683 IVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEGDMLI 747
            ||||||||:.|||.||||||.|.|||||||||::|||...|||||:||||:|||||:...||:||
Mouse   682 IVTSATMDAEKFAAFFGNVPIFHIPGRTFPVDILFSKTPQEDYVEAAVKQSLQVHLSGAPGDILI 746

  Fly   748 FMPGQEDIEVTCEVLEERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAET 812
            |||||||||||.:.:.|.|.|::|||||::||||||||||||||||||:.||:|||:||||||||
Mouse   747 FMPGQEDIEVTSDQIVEHLEELENAPALAVLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAET 811

  Fly   813 SLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYK 877
            |||||||::|||||||||||:|||||||||||||||||||||||||||||||||.:|||||..||
Mouse   812 SLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGRAGRTGPGQCFRLYTQSAYK 876

  Fly   878 DELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALT 942
            :|||..||||||||||||.|||||||||.||||||||||||:||:|||:||||||||||:||.||
Mouse   877 NELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQFHFMDPPPEDNMLNSMYQLWILGALDNTGGLT 941

  Fly   943 TLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPE 1007
            :.||.|.||||||...:||||:|.||||:|:|:||||||||:|||||||||:|:|.:||||..||
Mouse   942 STGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIVSMLSVPAIFYRPKGREEESDQIREKFAVPE 1006

  Fly  1008 SDHLTYLNVYQQWRQNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIVR 1072
            ||||||||||.||:.||||:.|||:||||.||||||||||.||||||.||.:|:.|||.||||||
Mouse  1007 SDHLTYLNVYLQWKNNNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSLASCGTDWDIVR 1071

  Fly  1073 KCICSAYFYQAARLKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATA 1137
            ||||:|||:|||:|||||||||:||||||||||||:|:|:|.||||:|||||:||.||||||.||
Mouse  1072 KCICAAYFHQAAKLKGIGEYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHELVMTTKEYMQCVTA 1136

  Fly  1138 VDGYWLAELGPMFFSVKESGRSGREKKKQAAEHLKEMEEQMLKAQHEMEERKQQAAEREEQLATK 1202
            |||.|||||||||:|||::|:|.:|.:::|.|....|||:|..|:.::..|:|:..:|....:.:
Mouse  1137 VDGEWLAELGPMFYSVKQAGKSRQENRRRAKEEASAMEEEMALAEEQLRARRQEQEKRSPLGSVR 1201

  Fly  1203 Q-EIATPGN------ATPRRTPARIGL 1222
            . :|.|||.      .||||||||.||
Mouse  1202 STKIYTPGRKEQGEPMTPRRTPARFGL 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	151/185 (82%)
		DEXDc	551..689	CDD:238005	116/137 (85%)
		HELICc	722..870	CDD:238034	119/147 (81%)
		HA2	932..1014	CDD:214852	59/81 (73%)
		OB_NTP_bind	1048..1148	CDD:285018	79/99 (80%)
Dhx38	NP_848467.1	DEXDc	527..714	CDD:214692	151/186 (81%)
		DEXDc	552..688	CDD:238005	115/135 (85%)
		HELICc	759..862	CDD:197757	85/102 (83%)
		HA2	931..1013	CDD:214852	59/81 (73%)
		OB_NTP_bind	<1064..1147	CDD:285018	68/82 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836962
Domainoid	1	1.000	423	1.000	Domainoid score	I627
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8512
Inparanoid	1	1.050	1487	1.000	Inparanoid score	I107
Isobase	1	0.950	-	0	Normalized mean entropy	S613
OMA	1	1.010	-	-		QHG52596
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		oto94528
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R986
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790