DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and dhx8

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	XP_002663993.1	Gene:	dhx8 / 606595	ZFINID:	ZDB-GENE-050809-39	Length:	1210	Species:	Danio rerio

Alignment Length:	1252	Identity:	495/1252 - (39%)
Similarity:	685/1252 - (54%)	Gaps:	221/1252 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 EKERSERLISF--KDSEFDD------TGGGSST---------------PQANASGASSEFAFKKP 101
            :|:.:|.:||.  |::.||.      ..|...|               |.|.||.:.:.|...||
Zfish    33 DKDLAEFVISLAEKNTAFDGFKSALVKNGADFTDSLIGNLLRLIQTMRPPAKASTSKASFPAAKP 97

  Fly   102 DTKSFEKL---------------RGQLREHKDDT--------------PSHTGGVSEKARERLRE 137
            ..:. :||               |..|.|  ||.              ||.:|.....::.|...
Zfish    98 KNEK-DKLKELFPALCRPDNPTTRNMLDE--DDVKVAADAMKELEMFMPSVSGTEPSSSKHRSET 159

  Fly   138 HIQRDRKRGPVSSTAAEGRDRDRDWDRDRRRDRDRDRDRDRDRRQHRERERDRHRSWDRDRGRDR 202
            .....:||        ..|.|.||.||||.|||:||||||| ||:||.|.|.|.||.:|||.:.|
Zfish   160 SSSSRKKR--------RSRSRSRDRDRDRDRDRERDRDRDR-RRRHRSRSRSRSRSNERDRRKRR 215

  Fly   203 DR--DRSMSERSVHTPREPGTPGGSSGGISNSSWDDED-------------------------GE 240
            .|  .||.|.....|.|:.|          :..|.|:.                         |.
Zfish   216 SRWHSRSRSRSPARTDRDKG----------SDRWKDKHVDRPPPEEPSVADIYNGKVTSIMQFGC 270

  Fly   241 F----GQRKSDWD----MPTPRRHGNKSGDWSVRSGGSR----------------RNHGRQDDTV 281
            |    |.||. |:    :...||.|..:....|.|.|.|                .....||...
Zfish   271 FVQLEGLRKR-WEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGSKTSLSMKDVDQDTGE 334

  Fly   282 RPTPAHRYNQWAHGRKRSGATPWGEDPESLDLWEEEQRRLDREWYNIDEGYDDENNPFGGPNSEY 346
            ...|..|.|....|::                 |...|..||. .|::.|:        .|..|
Zfish   335 DLNPNRRRNVGGEGQE-----------------ESAMRNPDRP-TNLNLGH--------APEVE- 372

  Fly   347 FRKREEQLEQKRTKRISAQQRQNNRDNELWERNRMLTSGVVT------------LISVNDDFDEE 399
                ::.||:||..:||        |.|.||..:|:.:.|::            ::...||.::|
Zfish   373 ----DDTLERKRLTKIS--------DPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDE 425

  Fly   400 ALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMALLARKGSALVRNYREQKE-RRKAQ 463
            .|| :.|:...  ||||.|....:....||..||:|...::..|...|||.:..||.|: :|:|:
Zfish   426 DLE-IELVEEE--PPFLRGHTKQSMDMSPVKIVKNPDGSLSQAAMMQSALAKERREVKQAQREAE 487

  Fly   464 --------KKHW-----ELSGTKL-GNIMGV-QRPQDEDDMRFDKEKDKADYRKDQKFADHMRDQ 513
                    .|||     ::.|.:: .|:.|: ..|.|..:.            |...|.
Zfish   488 MDSIPMGLNKHWVDPLPDVDGRQIAANMRGIGMMPNDIPEW------------KKHAFG------ 534

  Fly   514 DTGGKSDFSRKKTIS--EQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGY 576
              |.|:.:.:|..:|  |||..||::..:::|:..:.:|.::|::||||||||||:||||.|.||
Zfish   535 --GNKASYGKKTQLSILEQRESLPIYKLKEQLIQAVHDNQILIVIGETGSGKTTQITQYLAEAGY 597

  Fly   577 SKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLR 641
            :.||.|||||||||||||||||||:|....||::|||.||||||||..|||||||||:||||.|.
Zfish   598 TTRGKIGCTQPRRVAAMSVAKRVSEEYGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLI 662

  Fly   642 DPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTI 706
            ||:|..|:.|::||||||::.||||||||::.|.:|.|:||||||||:|:.||:.:|...|.|||
Zfish   663 DPDLGQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRTDMKLIVTSATLDAVKFSQYFYEAPIFTI 727

  Fly   707 PGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQEDIEVTCEVLEERLAEI-D 770
            ||||:||:|:::|....||:::::...:|:|||...||:|:|:.|||:|:..||:|.||:..: .
Zfish   728 PGRTYPVEVLYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGP 792

  Fly   771 NAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNP 835
            :.|.|.|||:||.|||::|.:||..:..|.||.|:||||||||||:|||.||:|.|:.|.||||.
Zfish   793 DVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNS 857

  Fly   836 RIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLL 900
            :.|:|.|.:.|||||.|.||:|||||||||:.|||||:|.|:||:|...||||||||||:|||.|
Zfish   858 KTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSL 922

  Fly   901 KSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVAC 965
            |::|:.|||.|.|||.||.:.::.::.||:.|||||..|.||.|||:||||||:|..|:|||::.
Zfish   923 KAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSV 987

  Fly   966 RMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNYSSTWC 1030
            .:|||.|:|.|||||||.::|||||.::..||..:.||.:||.||||.|.||..|:.|.:|:.||
Zfish   988 HLGCSEEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQPEGDHLTLLAVYNSWKNNKFSNPWC 1052

  Fly  1031 NEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIVRKCICSAYFYQAARLKGIGEYVNL 1095
            .|:||..:::|:.:::|:|:..||.:..|.|:|||.....|:|.|||.:|..||:......|..|
Zfish  1053 YENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKATVRVQKAICSGFFRNAAKKDPQEGYRTL 1117

  Fly  1096 RTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSVKESGRSG 1160
            ......::||:|||:  ...|::||||||::|.||||:..|.:|..||.|..|.||.|.:..|..
Zfish  1118 IDQQVVYIHPSSALF--NRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTRLS 1180

  Fly  1161 REKKKQAAEHLKEMEEQ 1177
            ::||:|..|.|....|:
Zfish  1181 KQKKQQRLEPLYNRYEE 1197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	118/185 (64%)
		DEXDc	551..689	CDD:238005	96/137 (70%)
		HELICc	722..870	CDD:238034	79/148 (53%)
		HA2	932..1014	CDD:214852	49/81 (60%)
		OB_NTP_bind	1048..1148	CDD:285018	40/99 (40%)
dhx8	XP_002663993.1	S1_DHX8_helicase	257..333	CDD:240189	15/76 (20%)
dhx8	XP_002663993.1	HrpA	542..1209	CDD:224557	350/658 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720