DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and DHX37

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	XP_005253647.1	Gene:	DHX37 / 57647	HGNCID:	17210	Length:	1175	Species:	Homo sapiens

Alignment Length:	1068	Identity:	282/1068 - (26%)
Similarity:	448/1068 - (41%)	Gaps:	268/1068 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 RYNQWAHGRKRSGATPWGEDPE----SLDLWEEEQRRLDREWYNIDEGYDDEN------------ 336
            |||  ..||:::|..|....||    .|:|.:::..:          |.|..|
Human     7 RYN--IKGRQQAGPGPSKGPPEPPPVQLELEDKDTLK----------GVDASNALVLPGKKKKKT 59

  Fly   337 --NPFGGPNSEYFRKREEQ-----LEQKRTKRISAQQRQNNRDNELWERNRML---TSGVVTLIS 391
              .|......:...|:|::     ||||..|...|:..|...:.:..|....|   ||.:.|
Human    60 KAPPLSKKEKKPLTKKEKKVLQKILEQKEKKSQRAEMLQKLSEVQASEAEMRLFYTTSKLGT--- 121

  Fly   392 VNDDFDEEALERVHLLVHHIIPPFLDGRIVFTKQ--PEPVVPVKDPTSDMALLARKGSALVRNYR 454
                                     ..|:..||:  .|.|.|.::..|.::...||.........
Human   122 -------------------------GNRMYHTKEKADEVVAPGQEKISSLSGAHRKRRRWPSAEE 161

  Fly   455 EQKERRKAQKKHWELS---------------GTKLGNIMGVQRPQDED---DMRFDKEKDKAD-- 499
            |::|..:::.:..|.|               ||.:..:.....|..:.   .|........|.
Human   162 EEEEEEESESELEEESELDEDPAAEPAEAGVGTTVAPLPPAPAPSSQPVPAGMTVPPPPAAAPPL 226

  Fly   500 ---YRKDQKFADHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGS 561
               ..|...|.            ..:|...:.|:|..||:.:..|.::..:.|:.::|:.|||||
Human   227 PRALAKPAVFI------------PVNRSPEMQEERLKLPILSEEQVIMEAVAEHPIVIVCGETGS 279

  Fly   562 GKTTQLTQYLHEDGYSKR-GMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERT 625
            |||||:.|:|:|.|:|.. .:||.|:||||||:::::||:.||:.. ...|.|.||:|...:|.|
Human   280 GKTTQVPQFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLS-QRVVSYQIRYEGNVTEET 343

  Fly   626 VIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIV---ARRH-DLKLIVTS 686
            .||:||||:||:|..:|..|..|..:|:|||||||:.||:|.|||..||   |:|: .|||::.|
Human   344 RIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMS 408

  Fly   687 ATMDSSKFA----TFFGNVPTFTIPGRTFPVDVMFSKNT-CEDYVESAVKQALQVHLTPNEGDML 746
            ||:....|.    .|....|...:..|.|||.|.|:|.| .|||.....::..::|.....|.:|
Human   409 ATLRVEDFTQNPRLFAKPPPVIKVESRQFPVTVHFNKRTPLEDYSGECFRKVCKIHRMLPAGGIL 473

  Fly   747 IFMPGQEDIEVTC-------------------------------------------EVL------ 762
            :|:.||.::...|                                           |||
Human   474 VFLTGQAEVHALCRRLRKAFPPSRARPQEKDDDQKDSVEEMRKFKKSRARAKKARAEVLPQINLD 538

  Fly   763 -----------EERLAEIDNAPA--------------------------LSILPIYSQLPSDLQA 790
                       |:|.||:|....                          |.:||:||.|..:.||
Human   539 HYSVLPAGEGDEDREAEVDEEEGALDSDLDLDLGDGGQDGGEQPDASLPLHVLPLYSLLAPEKQA 603

  Fly   791 KIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQR 855
            ::|:...:|.|.||||||:||||||:.||.||:|.|..|.:.|:...|:.:.::..:|||:|:||
Human   604 QVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQR 668

  Fly   856 SGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQD 920
            :||||||.||..||||:...:.| ......|||.|..:.:.:|.:|:|.|..::.|.|..||..:
Human   669 AGRAGRTEPGHCYRLYSSAVFGD-FEQFPPPEITRRPVEDLILQMKALNVEKVINFPFPTPPSVE 732

  Fly   921 NILNSLYQLWILGALDH---------------TGALTTLGRQMAEFPLDPPQCQMLIVACRMGCS 970
            .:|.:...|..||||..               :..:|.|||.||.||:.|...:||.::.:.||.
Human   733 ALLAAEELLIALGALQPPQKAERVKQLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCL 797

  Fly   971 AEVLIIVSMLSVPSIFY---RPKGREDEADGVREKFQRPE---------------SDHLTYLNVY 1017
            ...:.||:.::|..:|.   ||...::|...::.|..|..               .|.:..|...
Human   798 PYAITIVASMTVRELFEELDRPAASDEELTRLKSKRARVAQMKRTWAGQGASLKLGDLMVLLGAV 862

  Fly  1018 QQWRQNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIM------------------TQQNLS---- 1060
            ......:.:..:|..:.:..|||.::|.:|.||...:                  |:..::
Human   863 GACEYASCTPQFCEANGLRYKAMMEIRRLRGQLTTAVNAVCPEAELFVDPKMQPPTESQVTYLRQ 927

  Fly  1061 VISCGIDWDIVRKCICSAYFYQAARL---KGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYH 1122
            :::.|:...:.|:       .|:..:   |....|.......|..:||:|.|:  ...|::|||.
Human   928 IVTAGLGDHLARR-------VQSEEMLEDKWRNAYKTPLLDDPVFIHPSSVLF--KELPEFVVYQ 983

  Fly  1123 ELIMTAKEYMQCATAVDGYWLAELGPMF 1150
            |::.|.|.||:..::|:..|:..|.|.:
Human   984 EIVETTKMYMKGVSSVEVQWIPALLPSY 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	85/194 (44%)
		DEXDc	551..689	CDD:238005	71/142 (50%)
		HELICc	722..870	CDD:238034	65/233 (28%)
		HA2	932..1014	CDD:214852	27/114 (24%)
		OB_NTP_bind	1048..1148	CDD:285018	25/124 (20%)
DHX37	XP_005253647.1	HrpA	240..1016	CDD:224557	233/783 (30%)
		DEXDc	271..411	CDD:238005	71/140 (51%)
		P-loop_NTPase	<368..>511	CDD:304359	45/142 (32%)
		HELICc	585..674	CDD:197757	41/88 (47%)
		HA2	768..859	CDD:214852	23/90 (26%)
		OB_NTP_bind	894..1011	CDD:285018	26/125 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820