Protein Alignment Prp16 and ythdc2

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: XP_021332046.1
• Gene: ythdc2 / 567114
• ZFINID: ZDB-GENE-220119-1
• Length: 1381
• Species: Danio rerio
• Alignment Length: 1031
• Identity: 226/1031 - (21%)
• Similarity: 392/1031 - (38%)
• Gaps: 337/1031 - (32%)

  Fly   448 ALVRNYREQ-----KERRKAQKKHWELSGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRKDQKFA 507
            |||::..::     :||.:.| .|.|         .|:|.|.|..|     .|.:...|......
Zfish   115 ALVQSLMQRFPISSRERSQLQ-PHAE---------RGLQSPPDTTD-----SKSRTSGRLSHGIP 164

  Fly   508 DHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLH 572
            .....:.:..:.|..||.        |||:..:::::..||::.|::::||||||||||:.|:|.
Zfish   165 QVPPRRSSAPELDAFRKA--------LPVYELQEQIIQSIRDHQVVLVLGETGSGKTTQIPQFLL 221

  Fly   573 ED--GYSKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGIL 635
            :|  ..:....|.||||||:|.::||:||:.|....:|:.|||.||.|...|.:|::.:.|.|:|
Zfish   222 DDCSATASPCRIFCTQPRRLATIAVAERVAAERGENIGQTVGYQIRLESRVSPKTLLTFCTSGVL 286

  Fly   636 LRESLR-DPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFG 699
            ||..:. |..|.:.:.:|:||.|||...||.|...::|::.:..:|:|:::||.:|.|.|..:||
Zfish   287 LRTLMAGDEALSTVTHVIVDEVHERDGLTDFLLTKMKEVLQKMPNLRLVLSSAALDVSLFMRYFG 351

  Fly   700 NVPTFTIPGRTFPVDVMFSKN-------------------------------------------- 720
            :.|...|.|..:.|..:|.::
Zfish   352 SCPVIHIKGCPYEVKQLFLEDILRSTAYTNKDMIKYKKEAQKEESQQCSLSEWCERDVPQADPPE 416

  Fly   721 ----------------------------------------------------------------- 720
                                                                             
Zfish   417 RPTVCVLQDNQLLDDGGDSVFSQMSEKDVSSLEPWLLREMDSCISSIFLNQDADAFTQLFNLILN 481

  Fly   721 ----------------------------------------------------------------- 720
                                                                             
Zfish   482 ENISVDYRHSETSATALMVSAGRGFVSHTEQLLNMGANINIKASNGWTALDWAKHFKQTEAVDLL 546

  Fly   721 -------------------------TCED----------YVESAVKQALQVHL------TPNEGD 744
                                     :|||          :.:..|...|.:||      :.::|.
Zfish   547 ESHIWCAEASPQDEASLLQNSSCELSCEDQELLKAYHHSFDDEKVDLQLILHLLHSICQSSDQGA 611

  Fly   745 MLIFMPGQEDI-EVTCEVLEERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATN 808
            :|||:||.::| .:..::|.:.....::.....:..::|.:.:..|.|:.:.:..|:||.:::||
Zfish   612 VLIFLPGYDEIVSLRDQILFDDKRFTEHQQRFQVFVLHSSMQTSDQKKVLKSTPKGVRKIILSTN 676

  Fly   809 IAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQ 873
            |||||:||..:::|||||..|.|.|:....:..|::..||:|:|.||.|||||..||..:.|:::
Zfish   677 IAETSITVSDVVFVIDSGKVKEKAYDALNNVTMLKMVWISKASALQRKGRAGRCRPGVCFHLFSR 741

  Fly   874 RQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFM----DPPPQDNILNSLYQLWILGA 934
            .::.: :|...:|::.|..|....|..|.|..::.....|:    :||..:.:.:::..|..:.|
Zfish   742 LRFSN-MLEHQIPQLLRMPLQELCLHTKLLAPINCPVAEFLSRAPEPPHINTVKHAVQMLKTIDA 805

  Fly   935 LDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRP--KGREDEAD 997
            :|....||.||..:|:.|::|...:|::.|..:.|...||.|...|:....|..|  ..:...|.
Zfish   806 MDPWENLTELGLHLADLPVEPHLGKMVLCAVVLKCLDPVLTIACTLAHREPFVLPAQAAQRRVAM 870

  Fly   998 GVREKF-QRPESDHLTYLNVYQQW---RQNNYSSTWCNEHFIHIKAMRKVREVRQQL-------- 1050
            ..|.:| ....|||:..|..:|.|   |.:.:...:|.::|:....|..:..:|.||
Zfish   871 LCRRRFTANTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIVSMRTQLLGQLRATG 935

  Fly  1051 ----------KDIMTQQNLSVISCGIDWDIVRKCICSAYFYQAARLKGIGEYVNL--RTGM---- 1099
                      :|:  .||..      :|.:|:..:.:            |.|.||  |.|:
Zfish   936 FVRARGGGDIRDV--NQNSE------NWAVVKAALVA------------GMYPNLIHRDGLSLSG 980

  Fly  1100 ----PCHLHPTSAL---------------YGLGTTP-DYVVYHELIMTAK-EYMQCATAVDGYWL 1143
                ...|||||.|               ..:.:.| |:::|.|:....: ..::|.|||....:
Zfish   981 EKEKKVRLHPTSVLSQPQYKKIPPANGQAAAVDSLPTDWLIYDEMTRAHRIASVRCCTAVTPLTI 1045

  Fly  1144 AELGPMFFSVKESGRSGREKKKQAAEHLKEMEEQMLKAQHEMEERKQQAAEREEQL 1199
            |..|            |..|...:|  |:|...|...|.....|.:.|.:.|:..|
Zfish  1046 ALFG------------GGAKLPSSA--LQEAVLQRGSADSSDSEVEDQCSARQAHL 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	196/887 (22%)
ythdc2	XP_021332046.1	R3H_DEXH_helicase	36..94	CDD:100077
		PRK11131	169..>1003	CDD:182986	190/862 (22%)
		DEXHc_YTHDC2	183..358	CDD:350745	68/174 (39%)
		ANKYR	<473..>549	CDD:440430	0/75 (0%)
		ANK repeat	496..524	CDD:293786	0/27 (0%)
		SF2_C_RHA	584..739	CDD:350178	49/154 (32%)
		OB_NTP_bind	958..1050	CDD:400182	23/115 (20%)
		YTH	1249..1378	CDD:410979