DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and dhx34

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	XP_017207416.1	Gene:	dhx34 / 555838	ZFINID:	ZDB-GENE-061207-30	Length:	1154	Species:	Danio rerio

Alignment Length:	799	Identity:	241/799 - (30%)
Similarity:	400/799 - (50%)	Gaps:	88/799 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   451 RNYREQKE----RRKAQKKHWEL---SGTKLGNIMGVQRPQDED-DMRFDKEKDKADYRKDQKFA 507
            ::::.:||    :...|:||..|   ...|....:.:..|:|.| ..|.:......|..:....:
Zfish    51 QSFKAKKEMTASKSSRQEKHVALREGKAKKKTGCVDLGLPKDYDARYRINISVCSRDIEERLAGS 115

  Fly   508 DHMRDQDTG-GKS-------------DFSRKKTISE------QRRFLPVFASRQELLNVIRENSV 552
            ||.|.:.:| |:.             ||::|::.|:      :::.||:|..|.:::.::|.:.|
Zfish   116 DHRRRESSGPGRQEITDGRLALLHFLDFNQKQSFSKLSKLRREQKSLPIFQYRDKIVELVRTHPV 180

  Fly   553 IIIVGETGSGKTTQLTQYLHEDGYSKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRF 617
            :::.|:||.||:||:.|||...|.:.   |.||||||:|.:|:|||||.|...|.|..|||.|||
Zfish   181 VVVAGDTGCGKSTQVPQYLLASGINN---IACTQPRRIACISLAKRVSFESLNQYGSKVGYQIRF 242

  Fly   618 EDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKL 682
            |...:..|.:.::|:|:|||:..:|..|..|..:|:||.|||.|..|.|.|:||.:::.|.||:|
Zfish   243 ETSRTLATKLLFLTEGLLLRQIQQDASLGQYQVLIVDEVHERHLHCDFLLGVLRSLLSLRPDLRL 307

  Fly   683 IVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLT-------- 739
            ::.|||::...|:::|.:.|...:|||.||:.|::.....|:.|..:.|...:.:|.
Zfish   308 VLMSATINIKLFSSYFNDAPVLQVPGRLFPIQVIYQPIPPEEQVSRSEKLDPRPYLRVLQGIDQR 372

  Fly   740 -PNE--GDMLIFMPGQEDIEVTCEVLEERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLR 801
             |.|  ||:|:|:.|..:|....|..:   ....:.....:||::|.|....|.|:|..:..|:|
Zfish   373 YPQEERGDLLLFLSGVAEISTIQEACQ---TYATHTQRWIVLPLHSTLSLAQQDKVFDIAPPGVR 434

  Fly   802 KCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQ 866
            ||:::|||||||:|:||:.:|:|||..|...::|:..|..||.:.||:|::.||.|||||||||.
Zfish   435 KCIISTNIAETSVTIDGVRFVVDSGKVKEMSFDPKAKMQRLQEFWISRASSEQRKGRAGRTGPGV 499

  Fly   867 AYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWI 931
            .||||::..| |......||||.|..|.:.:|.:||:|:.|...|.|:||||..:|..::..|..
Zfish   500 CYRLYSESDY-DAFAPYPVPEIHRVALDSLILQMKSMGLGDPRTFTFIDPPPASSIQTAVTYLRE 563

  Fly   932 LGALDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEA 996
            .||||..|.||::||.:|:.|:|....:||::.........||.:.:.|||.|.|.|......:.
Zfish   564 QGALDEHGELTSIGRLLAQLPVDVVIGKMLVLGSVFNLVEPVLTVAAALSVQSPFLRSAQHNPDC 628

  Fly   997 DGVREKFQRPESDHLTYLNVYQQWRQ-----NNYSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQ 1056
            ...|:.......|..|.:|.:..|.|     .:.|..||....:..:.:.::..:|:|.|:::..
Zfish   629 STARQPLNSNHGDPFTLMNTFNAWVQVKADRGSGSRKWCRRRGLEEQRLYEMVNLRRQFKELLRS 693

  Fly  1057 QNLSVISCGIDWDIVRKCICSAYFYQAARLKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVY 1121
            ..|.....|...:...:......|.:..:|..:..                             .
Zfish   694 HGLLEDDTGRATEPQDRARRRERFTERQKLHQLKR-----------------------------D 729

  Fly  1122 HEL-IMTAKEYMQCATAVDGYWLAELGPMFFSVKESGRSGREKKKQAAEHLKEMEEQMLKAQHEM 1185
            ||| ..|.::.::....::|.  |..|    |..|...:.|:|:|..||...:::|...|.:|.:
Zfish   730 HELQENTKRKVLRLEEGLEGD--ASSG----SDAEESSTSRKKRKDGAEQTMDIQEVKFKLRHNV 788

  Fly  1186 EERKQQAAEREEQLATKQE 1204
            .| .|::|.....|::.|:
Zfish   789 NE-LQESAYASAALSSLQQ 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	77/191 (40%)
		DEXDc	551..689	CDD:238005	63/137 (46%)
		HELICc	722..870	CDD:238034	58/158 (37%)
		HA2	932..1014	CDD:214852	25/81 (31%)
		OB_NTP_bind	1048..1148	CDD:285018	12/100 (12%)
dhx34	XP_017207416.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810